Drosophila GPCR Han Is a Receptor for the Circadian Clock Neuropeptide PDF
The pigment-dispersing factor (PDF) is a neuropeptide controlling circadian behavioral rhythms in Drosophila, but its receptor is not yet known. From a large-scale temperature preference behavior screen in Drosophila, we isolated a P insertion mutant that preferred different temperatures during the...
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| Veröffentlicht in: | Neuron (Cambridge, Mass.) Mass.), 2005-10, Vol.48 (2), p.267-278 |
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| creator | Hyun, Seogang Lee, Youngseok Hong, Sung-Tae Bang, Sunhoe Paik, Donggi Kang, Jongkyun Shin, Jinwhan Lee, Jaejung Jeon, Keunhye Hwang, Seungyoon Bae, Eunkyung Kim, Jaeseob |
| description | The pigment-dispersing factor (PDF) is a neuropeptide controlling circadian behavioral rhythms in
Drosophila, but its receptor is not yet known. From a large-scale temperature preference behavior screen in
Drosophila, we isolated a P insertion mutant that preferred different temperatures during the day and night. This mutation, which we named
han, reduced the transcript level of
CG13758. We found that Han was expressed specifically in 13 pairs of circadian clock neurons in the adult brain.
han null flies showed arrhythmic circadian behavior in constant darkness. The behavioral characteristics of
han null mutants were similar to those of
pdf null mutants. We also found that PDF binds specifically to S2 cells expressing Han, which results in the elevation of cAMP synthesis. Therefore, we herein propose that Han is a PDF receptor regulating circadian behavioral rhythm through coordination of activities of clock neurons. |
| doi_str_mv | 10.1016/j.neuron.2005.08.025 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_68726913</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0896627305007002</els_id><sourcerecordid>68726913</sourcerecordid><originalsourceid>FETCH-LOGICAL-c465t-b115644242345f7e7d169c424fa8b6454f9524b2eadf363347d2b83ac9de68df3</originalsourceid><addsrcrecordid>eNqFkV1rHCEUhqU0NNuk_6AUoZC7maqjjt4UyqT5KCEJob0WR88Qt7PjVGcK_fd12YVCL9oLEfU558XzIPSWkpoSKj9s6wnWFKeaESJqomrCxAu0oUS3Fadav0QborSsJGubU_Q65y0hlAtNX6FTKhlnnLQb9OUyxRzn5zBafP3YPeEbO-HbjC1-AgfzEhMeylqeAXchOetDee_G6L7j-338XJjgAT9eXp2jk8GOGd4c9zP07erz1-6munu4vu0-3VWOS7FUPaVC8hLPGi6GFlpPpXblPFjVSy74oAXjPQPrh0Y2DW8961VjnfYgVbk7QxeHvnOKP1bIi9mF7GAc7QRxzUaqlklNm_-CjCimuWYFfP8XuI1rmsonDBWkkUJQxQvFD5QrI8sJBjOnsLPpl6HE7JWYrTkoMXslhihTlJSyd8fma78D_6fo6KAAHw8AlKH9DJBMdgEmBz4kcIvxMfw74TdTfJut</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1503655184</pqid></control><display><type>article</type><title>Drosophila GPCR Han Is a Receptor for the Circadian Clock Neuropeptide PDF</title><source>MEDLINE</source><source>Elsevier ScienceDirect Journals Complete</source><source>Cell Press Free Archives</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><creator>Hyun, Seogang ; Lee, Youngseok ; Hong, Sung-Tae ; Bang, Sunhoe ; Paik, Donggi ; Kang, Jongkyun ; Shin, Jinwhan ; Lee, Jaejung ; Jeon, Keunhye ; Hwang, Seungyoon ; Bae, Eunkyung ; Kim, Jaeseob</creator><creatorcontrib>Hyun, Seogang ; Lee, Youngseok ; Hong, Sung-Tae ; Bang, Sunhoe ; Paik, Donggi ; Kang, Jongkyun ; Shin, Jinwhan ; Lee, Jaejung ; Jeon, Keunhye ; Hwang, Seungyoon ; Bae, Eunkyung ; Kim, Jaeseob</creatorcontrib><description>The pigment-dispersing factor (PDF) is a neuropeptide controlling circadian behavioral rhythms in
Drosophila, but its receptor is not yet known. From a large-scale temperature preference behavior screen in
Drosophila, we isolated a P insertion mutant that preferred different temperatures during the day and night. This mutation, which we named
han, reduced the transcript level of
CG13758. We found that Han was expressed specifically in 13 pairs of circadian clock neurons in the adult brain.
han null flies showed arrhythmic circadian behavior in constant darkness. The behavioral characteristics of
han null mutants were similar to those of
pdf null mutants. We also found that PDF binds specifically to S2 cells expressing Han, which results in the elevation of cAMP synthesis. Therefore, we herein propose that Han is a PDF receptor regulating circadian behavioral rhythm through coordination of activities of clock neurons.</description><identifier>ISSN: 0896-6273</identifier><identifier>EISSN: 1097-4199</identifier><identifier>DOI: 10.1016/j.neuron.2005.08.025</identifier><identifier>PMID: 16242407</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Amino Acid Sequence ; Animals ; Antibodies - metabolism ; Behavior ; Behavior, Animal ; Binding, Competitive ; Blotting, Northern - methods ; Brain ; Brain - cytology ; Cell Line ; Circadian rhythm ; Circadian Rhythm - physiology ; Cyclic AMP - metabolism ; Dose-Response Relationship, Drug ; Drosophila ; Drosophila Proteins - genetics ; Drosophila Proteins - immunology ; Drosophila Proteins - metabolism ; Drosophila Proteins - physiology ; Gene expression ; Gene Expression Regulation - drug effects ; Gene Expression Regulation - physiology ; Immunohistochemistry - methods ; Insects ; Light ; Motor Activity - physiology ; Mutation ; Neurons - metabolism ; Neuropeptides ; Neuropeptides - metabolism ; Periodicity ; Protein Binding - physiology ; Receptors, G-Protein-Coupled - genetics ; Receptors, G-Protein-Coupled - immunology ; Receptors, G-Protein-Coupled - metabolism ; Receptors, G-Protein-Coupled - physiology ; Reverse Transcriptase Polymerase Chain Reaction - methods ; RNA, Messenger - biosynthesis ; Sequence Alignment ; Thermosensing - genetics ; Thermosensing - physiology</subject><ispartof>Neuron (Cambridge, Mass.), 2005-10, Vol.48 (2), p.267-278</ispartof><rights>2005 Elsevier Inc.</rights><rights>Copyright Elsevier Limited Oct 20, 2005</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c465t-b115644242345f7e7d169c424fa8b6454f9524b2eadf363347d2b83ac9de68df3</citedby><cites>FETCH-LOGICAL-c465t-b115644242345f7e7d169c424fa8b6454f9524b2eadf363347d2b83ac9de68df3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0896627305007002$$EHTML$$P50$$Gelsevier$$Hfree_for_read</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65534</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16242407$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Hyun, Seogang</creatorcontrib><creatorcontrib>Lee, Youngseok</creatorcontrib><creatorcontrib>Hong, Sung-Tae</creatorcontrib><creatorcontrib>Bang, Sunhoe</creatorcontrib><creatorcontrib>Paik, Donggi</creatorcontrib><creatorcontrib>Kang, Jongkyun</creatorcontrib><creatorcontrib>Shin, Jinwhan</creatorcontrib><creatorcontrib>Lee, Jaejung</creatorcontrib><creatorcontrib>Jeon, Keunhye</creatorcontrib><creatorcontrib>Hwang, Seungyoon</creatorcontrib><creatorcontrib>Bae, Eunkyung</creatorcontrib><creatorcontrib>Kim, Jaeseob</creatorcontrib><title>Drosophila GPCR Han Is a Receptor for the Circadian Clock Neuropeptide PDF</title><title>Neuron (Cambridge, Mass.)</title><addtitle>Neuron</addtitle><description>The pigment-dispersing factor (PDF) is a neuropeptide controlling circadian behavioral rhythms in
Drosophila, but its receptor is not yet known. From a large-scale temperature preference behavior screen in
Drosophila, we isolated a P insertion mutant that preferred different temperatures during the day and night. This mutation, which we named
han, reduced the transcript level of
CG13758. We found that Han was expressed specifically in 13 pairs of circadian clock neurons in the adult brain.
han null flies showed arrhythmic circadian behavior in constant darkness. The behavioral characteristics of
han null mutants were similar to those of
pdf null mutants. We also found that PDF binds specifically to S2 cells expressing Han, which results in the elevation of cAMP synthesis. Therefore, we herein propose that Han is a PDF receptor regulating circadian behavioral rhythm through coordination of activities of clock neurons.</description><subject>Amino Acid Sequence</subject><subject>Animals</subject><subject>Antibodies - metabolism</subject><subject>Behavior</subject><subject>Behavior, Animal</subject><subject>Binding, Competitive</subject><subject>Blotting, Northern - methods</subject><subject>Brain</subject><subject>Brain - cytology</subject><subject>Cell Line</subject><subject>Circadian rhythm</subject><subject>Circadian Rhythm - physiology</subject><subject>Cyclic AMP - metabolism</subject><subject>Dose-Response Relationship, Drug</subject><subject>Drosophila</subject><subject>Drosophila Proteins - genetics</subject><subject>Drosophila Proteins - immunology</subject><subject>Drosophila Proteins - metabolism</subject><subject>Drosophila Proteins - physiology</subject><subject>Gene expression</subject><subject>Gene Expression Regulation - drug effects</subject><subject>Gene Expression Regulation - physiology</subject><subject>Immunohistochemistry - methods</subject><subject>Insects</subject><subject>Light</subject><subject>Motor Activity - physiology</subject><subject>Mutation</subject><subject>Neurons - metabolism</subject><subject>Neuropeptides</subject><subject>Neuropeptides - metabolism</subject><subject>Periodicity</subject><subject>Protein Binding - physiology</subject><subject>Receptors, G-Protein-Coupled - genetics</subject><subject>Receptors, G-Protein-Coupled - immunology</subject><subject>Receptors, G-Protein-Coupled - metabolism</subject><subject>Receptors, G-Protein-Coupled - physiology</subject><subject>Reverse Transcriptase Polymerase Chain Reaction - methods</subject><subject>RNA, Messenger - biosynthesis</subject><subject>Sequence Alignment</subject><subject>Thermosensing - genetics</subject><subject>Thermosensing - physiology</subject><issn>0896-6273</issn><issn>1097-4199</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkV1rHCEUhqU0NNuk_6AUoZC7maqjjt4UyqT5KCEJob0WR88Qt7PjVGcK_fd12YVCL9oLEfU558XzIPSWkpoSKj9s6wnWFKeaESJqomrCxAu0oUS3Fadav0QborSsJGubU_Q65y0hlAtNX6FTKhlnnLQb9OUyxRzn5zBafP3YPeEbO-HbjC1-AgfzEhMeylqeAXchOetDee_G6L7j-338XJjgAT9eXp2jk8GOGd4c9zP07erz1-6munu4vu0-3VWOS7FUPaVC8hLPGi6GFlpPpXblPFjVSy74oAXjPQPrh0Y2DW8961VjnfYgVbk7QxeHvnOKP1bIi9mF7GAc7QRxzUaqlklNm_-CjCimuWYFfP8XuI1rmsonDBWkkUJQxQvFD5QrI8sJBjOnsLPpl6HE7JWYrTkoMXslhihTlJSyd8fma78D_6fo6KAAHw8AlKH9DJBMdgEmBz4kcIvxMfw74TdTfJut</recordid><startdate>20051020</startdate><enddate>20051020</enddate><creator>Hyun, Seogang</creator><creator>Lee, Youngseok</creator><creator>Hong, Sung-Tae</creator><creator>Bang, Sunhoe</creator><creator>Paik, Donggi</creator><creator>Kang, Jongkyun</creator><creator>Shin, Jinwhan</creator><creator>Lee, Jaejung</creator><creator>Jeon, Keunhye</creator><creator>Hwang, Seungyoon</creator><creator>Bae, Eunkyung</creator><creator>Kim, Jaeseob</creator><general>Elsevier Inc</general><general>Elsevier Limited</general><scope>6I.</scope><scope>AAFTH</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>7QR</scope><scope>7TK</scope><scope>8FD</scope><scope>FR3</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>P64</scope><scope>RC3</scope><scope>7SS</scope><scope>7X8</scope></search><sort><creationdate>20051020</creationdate><title>Drosophila GPCR Han Is a Receptor for the Circadian Clock Neuropeptide PDF</title><author>Hyun, Seogang ; Lee, Youngseok ; Hong, Sung-Tae ; Bang, Sunhoe ; Paik, Donggi ; Kang, Jongkyun ; Shin, Jinwhan ; Lee, Jaejung ; Jeon, Keunhye ; Hwang, Seungyoon ; Bae, Eunkyung ; Kim, Jaeseob</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c465t-b115644242345f7e7d169c424fa8b6454f9524b2eadf363347d2b83ac9de68df3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>Amino Acid Sequence</topic><topic>Animals</topic><topic>Antibodies - metabolism</topic><topic>Behavior</topic><topic>Behavior, Animal</topic><topic>Binding, Competitive</topic><topic>Blotting, Northern - methods</topic><topic>Brain</topic><topic>Brain - cytology</topic><topic>Cell Line</topic><topic>Circadian rhythm</topic><topic>Circadian Rhythm - physiology</topic><topic>Cyclic AMP - metabolism</topic><topic>Dose-Response Relationship, Drug</topic><topic>Drosophila</topic><topic>Drosophila Proteins - genetics</topic><topic>Drosophila Proteins - immunology</topic><topic>Drosophila Proteins - metabolism</topic><topic>Drosophila Proteins - physiology</topic><topic>Gene expression</topic><topic>Gene Expression Regulation - drug effects</topic><topic>Gene Expression Regulation - physiology</topic><topic>Immunohistochemistry - methods</topic><topic>Insects</topic><topic>Light</topic><topic>Motor Activity - physiology</topic><topic>Mutation</topic><topic>Neurons - metabolism</topic><topic>Neuropeptides</topic><topic>Neuropeptides - metabolism</topic><topic>Periodicity</topic><topic>Protein Binding - physiology</topic><topic>Receptors, G-Protein-Coupled - genetics</topic><topic>Receptors, G-Protein-Coupled - immunology</topic><topic>Receptors, G-Protein-Coupled - metabolism</topic><topic>Receptors, G-Protein-Coupled - physiology</topic><topic>Reverse Transcriptase Polymerase Chain Reaction - methods</topic><topic>RNA, Messenger - biosynthesis</topic><topic>Sequence Alignment</topic><topic>Thermosensing - genetics</topic><topic>Thermosensing - physiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hyun, Seogang</creatorcontrib><creatorcontrib>Lee, Youngseok</creatorcontrib><creatorcontrib>Hong, Sung-Tae</creatorcontrib><creatorcontrib>Bang, Sunhoe</creatorcontrib><creatorcontrib>Paik, Donggi</creatorcontrib><creatorcontrib>Kang, Jongkyun</creatorcontrib><creatorcontrib>Shin, Jinwhan</creatorcontrib><creatorcontrib>Lee, Jaejung</creatorcontrib><creatorcontrib>Jeon, Keunhye</creatorcontrib><creatorcontrib>Hwang, Seungyoon</creatorcontrib><creatorcontrib>Bae, Eunkyung</creatorcontrib><creatorcontrib>Kim, Jaeseob</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>Entomology Abstracts (Full archive)</collection><collection>MEDLINE - Academic</collection><jtitle>Neuron (Cambridge, Mass.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hyun, Seogang</au><au>Lee, Youngseok</au><au>Hong, Sung-Tae</au><au>Bang, Sunhoe</au><au>Paik, Donggi</au><au>Kang, Jongkyun</au><au>Shin, Jinwhan</au><au>Lee, Jaejung</au><au>Jeon, Keunhye</au><au>Hwang, Seungyoon</au><au>Bae, Eunkyung</au><au>Kim, Jaeseob</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Drosophila GPCR Han Is a Receptor for the Circadian Clock Neuropeptide PDF</atitle><jtitle>Neuron (Cambridge, Mass.)</jtitle><addtitle>Neuron</addtitle><date>2005-10-20</date><risdate>2005</risdate><volume>48</volume><issue>2</issue><spage>267</spage><epage>278</epage><pages>267-278</pages><issn>0896-6273</issn><eissn>1097-4199</eissn><abstract>The pigment-dispersing factor (PDF) is a neuropeptide controlling circadian behavioral rhythms in
Drosophila, but its receptor is not yet known. From a large-scale temperature preference behavior screen in
Drosophila, we isolated a P insertion mutant that preferred different temperatures during the day and night. This mutation, which we named
han, reduced the transcript level of
CG13758. We found that Han was expressed specifically in 13 pairs of circadian clock neurons in the adult brain.
han null flies showed arrhythmic circadian behavior in constant darkness. The behavioral characteristics of
han null mutants were similar to those of
pdf null mutants. We also found that PDF binds specifically to S2 cells expressing Han, which results in the elevation of cAMP synthesis. Therefore, we herein propose that Han is a PDF receptor regulating circadian behavioral rhythm through coordination of activities of clock neurons.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>16242407</pmid><doi>10.1016/j.neuron.2005.08.025</doi><tpages>12</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Amino Acid Sequence Animals Antibodies - metabolism Behavior Behavior, Animal Binding, Competitive Blotting, Northern - methods Brain Brain - cytology Cell Line Circadian rhythm Circadian Rhythm - physiology Cyclic AMP - metabolism Dose-Response Relationship, Drug Drosophila Drosophila Proteins - genetics Drosophila Proteins - immunology Drosophila Proteins - metabolism Drosophila Proteins - physiology Gene expression Gene Expression Regulation - drug effects Gene Expression Regulation - physiology Immunohistochemistry - methods Insects Light Motor Activity - physiology Mutation Neurons - metabolism Neuropeptides Neuropeptides - metabolism Periodicity Protein Binding - physiology Receptors, G-Protein-Coupled - genetics Receptors, G-Protein-Coupled - immunology Receptors, G-Protein-Coupled - metabolism Receptors, G-Protein-Coupled - physiology Reverse Transcriptase Polymerase Chain Reaction - methods RNA, Messenger - biosynthesis Sequence Alignment Thermosensing - genetics Thermosensing - physiology |
| title | Drosophila GPCR Han Is a Receptor for the Circadian Clock Neuropeptide PDF |
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