Differentiation of Phyllodes Breast Tumors from Fibroadenomas on MRI
The purpose of our study was to evaluate the MRI appearance of phyllodes breast tumors and to differentiate them from fibroadenomas. MR images were obtained on a 1.5-T imager. T1- and T2-weighted sequences and dynamic 2D fast-field echo T1-weighted sequences were performed. MR images of 23 patients...
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| Veröffentlicht in: | American journal of roentgenology (1976) 2005-11, Vol.185 (5), p.1317-1321 |
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| container_title | American journal of roentgenology (1976) |
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| creator | Wurdinger, Susanne Herzog, Aimee B Fischer, Dorothee R Marx, Christiane Raabe, Gerd Schneider, Achim Kaiser, Werner A |
| description | The purpose of our study was to evaluate the MRI appearance of phyllodes breast tumors and to differentiate them from fibroadenomas.
MR images were obtained on a 1.5-T imager. T1- and T2-weighted sequences and dynamic 2D fast-field echo T1-weighted sequences were performed. MR images of 23 patients with 24 phyllodes breast tumors (one malignant, 23 benign) were analyzed with respect to morphology and contrast enhancement. The tumors were compared with the MRI appearance of 81 fibroadenomas of 75 patients.
Well-defined margins were seen in 87.5% of the phyllodes tumors and 70.4% of the fibroadenomas, and a round or lobulated shape in 100% and 90.1%, respectively. A heterogeneous internal structure was observed in 70.8% of phyllodes tumors and in 49.4% of fibroadenomas. Nonenhancing internal septations were found in 45.8% of phyllodes tumors and 27.2% of fibroadenomas. A significantly greater increase in signal was seen on T2-weighted images in the tissue surrounding phyllodes tumors (21%) compared with fibroadenomas (1.2%). Most of both lesions appeared with low signal intensity on T1- and T2-weighted images. After the administration of contrast material, 33.3% of phyllodes tumors and 22.2% of fibroadenomas showed a suspicious signal intensity-time course.
Phyllodes breast tumors and other fibroadenomas cannot be precisely differentiated on breast MRI. Phyllodes tumors have benign morphologic features and contrast enhancement characteristics suggestive of malignancy in 33% of cases. |
| doi_str_mv | 10.2214/AJR.04.1620 |
| format | Article |
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MR images were obtained on a 1.5-T imager. T1- and T2-weighted sequences and dynamic 2D fast-field echo T1-weighted sequences were performed. MR images of 23 patients with 24 phyllodes breast tumors (one malignant, 23 benign) were analyzed with respect to morphology and contrast enhancement. The tumors were compared with the MRI appearance of 81 fibroadenomas of 75 patients.
Well-defined margins were seen in 87.5% of the phyllodes tumors and 70.4% of the fibroadenomas, and a round or lobulated shape in 100% and 90.1%, respectively. A heterogeneous internal structure was observed in 70.8% of phyllodes tumors and in 49.4% of fibroadenomas. Nonenhancing internal septations were found in 45.8% of phyllodes tumors and 27.2% of fibroadenomas. A significantly greater increase in signal was seen on T2-weighted images in the tissue surrounding phyllodes tumors (21%) compared with fibroadenomas (1.2%). Most of both lesions appeared with low signal intensity on T1- and T2-weighted images. After the administration of contrast material, 33.3% of phyllodes tumors and 22.2% of fibroadenomas showed a suspicious signal intensity-time course.
Phyllodes breast tumors and other fibroadenomas cannot be precisely differentiated on breast MRI. Phyllodes tumors have benign morphologic features and contrast enhancement characteristics suggestive of malignancy in 33% of cases.</description><identifier>ISSN: 0361-803X</identifier><identifier>EISSN: 1546-3141</identifier><identifier>DOI: 10.2214/AJR.04.1620</identifier><identifier>PMID: 16247156</identifier><identifier>CODEN: AAJRDX</identifier><language>eng</language><publisher>Leesburg, VA: Am Roentgen Ray Soc</publisher><subject>Adolescent ; Adult ; Aged ; Aged, 80 and over ; Biological and medical sciences ; Breast Neoplasms - diagnosis ; Contrast Media ; Diagnosis, Differential ; Female ; Fibroadenoma - diagnosis ; Gadolinium DTPA ; Gynecology. Andrology. Obstetrics ; Humans ; Magnetic Resonance Imaging ; Mammary gland diseases ; Medical sciences ; Middle Aged ; Phyllodes Tumor - diagnosis ; Tumors</subject><ispartof>American journal of roentgenology (1976), 2005-11, Vol.185 (5), p.1317-1321</ispartof><rights>2005 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c457t-b8693dddf42f151ff6f65c7aa4524fa99d4500cc7d094b5ad8b4a16964fe383</citedby><cites>FETCH-LOGICAL-c457t-b8693dddf42f151ff6f65c7aa4524fa99d4500cc7d094b5ad8b4a16964fe383</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,4120,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=17219479$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16247156$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Wurdinger, Susanne</creatorcontrib><creatorcontrib>Herzog, Aimee B</creatorcontrib><creatorcontrib>Fischer, Dorothee R</creatorcontrib><creatorcontrib>Marx, Christiane</creatorcontrib><creatorcontrib>Raabe, Gerd</creatorcontrib><creatorcontrib>Schneider, Achim</creatorcontrib><creatorcontrib>Kaiser, Werner A</creatorcontrib><title>Differentiation of Phyllodes Breast Tumors from Fibroadenomas on MRI</title><title>American journal of roentgenology (1976)</title><addtitle>AJR Am J Roentgenol</addtitle><description>The purpose of our study was to evaluate the MRI appearance of phyllodes breast tumors and to differentiate them from fibroadenomas.
MR images were obtained on a 1.5-T imager. T1- and T2-weighted sequences and dynamic 2D fast-field echo T1-weighted sequences were performed. MR images of 23 patients with 24 phyllodes breast tumors (one malignant, 23 benign) were analyzed with respect to morphology and contrast enhancement. The tumors were compared with the MRI appearance of 81 fibroadenomas of 75 patients.
Well-defined margins were seen in 87.5% of the phyllodes tumors and 70.4% of the fibroadenomas, and a round or lobulated shape in 100% and 90.1%, respectively. A heterogeneous internal structure was observed in 70.8% of phyllodes tumors and in 49.4% of fibroadenomas. Nonenhancing internal septations were found in 45.8% of phyllodes tumors and 27.2% of fibroadenomas. A significantly greater increase in signal was seen on T2-weighted images in the tissue surrounding phyllodes tumors (21%) compared with fibroadenomas (1.2%). Most of both lesions appeared with low signal intensity on T1- and T2-weighted images. After the administration of contrast material, 33.3% of phyllodes tumors and 22.2% of fibroadenomas showed a suspicious signal intensity-time course.
Phyllodes breast tumors and other fibroadenomas cannot be precisely differentiated on breast MRI. Phyllodes tumors have benign morphologic features and contrast enhancement characteristics suggestive of malignancy in 33% of cases.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Biological and medical sciences</subject><subject>Breast Neoplasms - diagnosis</subject><subject>Contrast Media</subject><subject>Diagnosis, Differential</subject><subject>Female</subject><subject>Fibroadenoma - diagnosis</subject><subject>Gadolinium DTPA</subject><subject>Gynecology. Andrology. Obstetrics</subject><subject>Humans</subject><subject>Magnetic Resonance Imaging</subject><subject>Mammary gland diseases</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Phyllodes Tumor - diagnosis</subject><subject>Tumors</subject><issn>0361-803X</issn><issn>1546-3141</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpF0DtPwzAUhmELgWgpTOwoCzCgFJ_El2TkVigCgUoHNsuJbWqUxGCnivj3pGqkTmd5zje8CJ0CniYJkOub58UUkymwBO-hMVDC4hQI7KMxThnEGU4_R-gohG-MMc9yfohGvSUcKBuj-3trjPa6aa1srWsiZ6L31V9VOaVDdOu1DG20XNfOh8h4V0czW3gnlW5cLUPUP7wu5sfowMgq6JPhTtDH7GF59xS_vD3O725e4pJQ3sZFxvJUKWVIYoCCMcwwWnIpCU2IkXmuCMW4LLnCOSmoVFlBJLCcEaPTLJ2gi-3qj3e_ax1aUdtQ6qqSjXbrIFjGEwaM9vBqC0vvQvDaiB9va-n_BGCxSSb6ZAITsUnW67Nhdl3UWu3s0KgH5wOQoZSV8bIpbdg5nkBOeN67y61b2a9VZ70WoZZV1c-C6LoOMiqogBR4-g_ApoCJ</recordid><startdate>20051101</startdate><enddate>20051101</enddate><creator>Wurdinger, Susanne</creator><creator>Herzog, Aimee B</creator><creator>Fischer, Dorothee R</creator><creator>Marx, Christiane</creator><creator>Raabe, Gerd</creator><creator>Schneider, Achim</creator><creator>Kaiser, Werner A</creator><general>Am Roentgen Ray Soc</general><general>American Roentgen Ray Society</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20051101</creationdate><title>Differentiation of Phyllodes Breast Tumors from Fibroadenomas on MRI</title><author>Wurdinger, Susanne ; Herzog, Aimee B ; Fischer, Dorothee R ; Marx, Christiane ; Raabe, Gerd ; Schneider, Achim ; Kaiser, Werner A</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c457t-b8693dddf42f151ff6f65c7aa4524fa99d4500cc7d094b5ad8b4a16964fe383</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Biological and medical sciences</topic><topic>Breast Neoplasms - diagnosis</topic><topic>Contrast Media</topic><topic>Diagnosis, Differential</topic><topic>Female</topic><topic>Fibroadenoma - diagnosis</topic><topic>Gadolinium DTPA</topic><topic>Gynecology. Andrology. Obstetrics</topic><topic>Humans</topic><topic>Magnetic Resonance Imaging</topic><topic>Mammary gland diseases</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Phyllodes Tumor - diagnosis</topic><topic>Tumors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Wurdinger, Susanne</creatorcontrib><creatorcontrib>Herzog, Aimee B</creatorcontrib><creatorcontrib>Fischer, Dorothee R</creatorcontrib><creatorcontrib>Marx, Christiane</creatorcontrib><creatorcontrib>Raabe, Gerd</creatorcontrib><creatorcontrib>Schneider, Achim</creatorcontrib><creatorcontrib>Kaiser, Werner A</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>American journal of roentgenology (1976)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wurdinger, Susanne</au><au>Herzog, Aimee B</au><au>Fischer, Dorothee R</au><au>Marx, Christiane</au><au>Raabe, Gerd</au><au>Schneider, Achim</au><au>Kaiser, Werner A</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Differentiation of Phyllodes Breast Tumors from Fibroadenomas on MRI</atitle><jtitle>American journal of roentgenology (1976)</jtitle><addtitle>AJR Am J Roentgenol</addtitle><date>2005-11-01</date><risdate>2005</risdate><volume>185</volume><issue>5</issue><spage>1317</spage><epage>1321</epage><pages>1317-1321</pages><issn>0361-803X</issn><eissn>1546-3141</eissn><coden>AAJRDX</coden><abstract>The purpose of our study was to evaluate the MRI appearance of phyllodes breast tumors and to differentiate them from fibroadenomas.
MR images were obtained on a 1.5-T imager. T1- and T2-weighted sequences and dynamic 2D fast-field echo T1-weighted sequences were performed. MR images of 23 patients with 24 phyllodes breast tumors (one malignant, 23 benign) were analyzed with respect to morphology and contrast enhancement. The tumors were compared with the MRI appearance of 81 fibroadenomas of 75 patients.
Well-defined margins were seen in 87.5% of the phyllodes tumors and 70.4% of the fibroadenomas, and a round or lobulated shape in 100% and 90.1%, respectively. A heterogeneous internal structure was observed in 70.8% of phyllodes tumors and in 49.4% of fibroadenomas. Nonenhancing internal septations were found in 45.8% of phyllodes tumors and 27.2% of fibroadenomas. A significantly greater increase in signal was seen on T2-weighted images in the tissue surrounding phyllodes tumors (21%) compared with fibroadenomas (1.2%). Most of both lesions appeared with low signal intensity on T1- and T2-weighted images. After the administration of contrast material, 33.3% of phyllodes tumors and 22.2% of fibroadenomas showed a suspicious signal intensity-time course.
Phyllodes breast tumors and other fibroadenomas cannot be precisely differentiated on breast MRI. Phyllodes tumors have benign morphologic features and contrast enhancement characteristics suggestive of malignancy in 33% of cases.</abstract><cop>Leesburg, VA</cop><pub>Am Roentgen Ray Soc</pub><pmid>16247156</pmid><doi>10.2214/AJR.04.1620</doi><tpages>5</tpages></addata></record> |
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| source | American Roentgen Ray Society; MEDLINE; Alma/SFX Local Collection |
| subjects | Adolescent Adult Aged Aged, 80 and over Biological and medical sciences Breast Neoplasms - diagnosis Contrast Media Diagnosis, Differential Female Fibroadenoma - diagnosis Gadolinium DTPA Gynecology. Andrology. Obstetrics Humans Magnetic Resonance Imaging Mammary gland diseases Medical sciences Middle Aged Phyllodes Tumor - diagnosis Tumors |
| title | Differentiation of Phyllodes Breast Tumors from Fibroadenomas on MRI |
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