PDF Receptor Signaling in Drosophila Contributes to Both Circadian and Geotactic Behaviors
The neuropeptide Pigment-Dispersing Factor (PDF) is a principle transmitter regulating circadian locomotor rhythms in Drosophila. We have identified a Class II (secretin-related) G protein-coupled receptor (GPCR) that is specifically responsive to PDF and also to calcitonin-like peptides and to PACA...
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| Veröffentlicht in: | Neuron (Cambridge, Mass.) Mass.), 2005-10, Vol.48 (2), p.213-219 |
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| container_title | Neuron (Cambridge, Mass.) |
| container_volume | 48 |
| creator | Mertens, Inge Vandingenen, Anick Johnson, Erik C. Shafer, Orie T. Li, W. Trigg, J.S. De Loof, Arnold Schoofs, Liliane Taghert, Paul H. |
| description | The neuropeptide Pigment-Dispersing Factor (PDF) is a principle transmitter regulating circadian locomotor rhythms in
Drosophila. We have identified a Class II (secretin-related) G protein-coupled receptor (GPCR) that is specifically responsive to PDF and also to calcitonin-like peptides and to PACAP. In response to PDF, the PDF receptor (PDFR) elevates cAMP levels when expressed in HEK293 cells. As predicted by in vivo studies, cotransfection of
Neurofibromatosis Factor 1 significantly improves coupling of PDFR to adenylate cyclase.
pdfr mutant flies display increased circadian arrhythmicity, and also display altered geotaxis that is epistatic to that of
pdf mutants. PDFR immunosignals are expressed by diverse neurons, but only by a small subset of circadian pacemakers. These data establish the first synapse within the
Drosophila circadian neural circuit and underscore the importance of Class II peptide GPCR signaling in circadian neural systems. |
| doi_str_mv | 10.1016/j.neuron.2005.09.009 |
| format | Article |
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Drosophila. We have identified a Class II (secretin-related) G protein-coupled receptor (GPCR) that is specifically responsive to PDF and also to calcitonin-like peptides and to PACAP. In response to PDF, the PDF receptor (PDFR) elevates cAMP levels when expressed in HEK293 cells. As predicted by in vivo studies, cotransfection of
Neurofibromatosis Factor 1 significantly improves coupling of PDFR to adenylate cyclase.
pdfr mutant flies display increased circadian arrhythmicity, and also display altered geotaxis that is epistatic to that of
pdf mutants. PDFR immunosignals are expressed by diverse neurons, but only by a small subset of circadian pacemakers. These data establish the first synapse within the
Drosophila circadian neural circuit and underscore the importance of Class II peptide GPCR signaling in circadian neural systems.</description><identifier>ISSN: 0896-6273</identifier><identifier>EISSN: 1097-4199</identifier><identifier>DOI: 10.1016/j.neuron.2005.09.009</identifier><identifier>PMID: 16242402</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Adrenomedullin ; Animals ; Animals, Genetically Modified ; Behavior ; Behavior, Animal - physiology ; Blotting, Western - methods ; Brain - cytology ; Brain - metabolism ; Calcitonin - pharmacology ; Cell Line ; Circadian rhythm ; Circadian Rhythm - physiology ; Dose-Response Relationship, Drug ; Drosophila ; Drosophila Proteins - genetics ; Drosophila Proteins - pharmacology ; Drosophila Proteins - physiology ; Gene Expression Regulation - physiology ; Genes, Insect ; Genomes ; Humans ; Immunohistochemistry - methods ; Insects ; Maze Learning ; Motor Activity - genetics ; Motor Activity - physiology ; Mutagenesis - physiology ; Mutation ; Nerve Tissue Proteins - physiology ; Neurons ; Neurons - metabolism ; Neuropeptides ; Neuropeptides - pharmacology ; Neuropeptides - physiology ; Orientation - physiology ; Peptides ; Peptides - pharmacology ; Proteins ; ras GTPase-Activating Proteins - physiology ; Receptors, G-Protein-Coupled - genetics ; Receptors, G-Protein-Coupled - physiology ; Reverse Transcriptase Polymerase Chain Reaction - methods ; RNA, Messenger - biosynthesis ; Rodents ; Signal Transduction - drug effects ; Signal Transduction - physiology ; Transfection - methods ; Transmitters ; Variance analysis</subject><ispartof>Neuron (Cambridge, Mass.), 2005-10, Vol.48 (2), p.213-219</ispartof><rights>2005 Elsevier Inc.</rights><rights>Copyright Elsevier Limited Oct 20, 2005</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c531t-9bad8d222e56d7461111e42903a0bee7a1b835d79aa0580dc64e0d58d9bcbd8d3</citedby><cites>FETCH-LOGICAL-c531t-9bad8d222e56d7461111e42903a0bee7a1b835d79aa0580dc64e0d58d9bcbd8d3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0896627305007762$$EHTML$$P50$$Gelsevier$$Hfree_for_read</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16242402$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Mertens, Inge</creatorcontrib><creatorcontrib>Vandingenen, Anick</creatorcontrib><creatorcontrib>Johnson, Erik C.</creatorcontrib><creatorcontrib>Shafer, Orie T.</creatorcontrib><creatorcontrib>Li, W.</creatorcontrib><creatorcontrib>Trigg, J.S.</creatorcontrib><creatorcontrib>De Loof, Arnold</creatorcontrib><creatorcontrib>Schoofs, Liliane</creatorcontrib><creatorcontrib>Taghert, Paul H.</creatorcontrib><title>PDF Receptor Signaling in Drosophila Contributes to Both Circadian and Geotactic Behaviors</title><title>Neuron (Cambridge, Mass.)</title><addtitle>Neuron</addtitle><description>The neuropeptide Pigment-Dispersing Factor (PDF) is a principle transmitter regulating circadian locomotor rhythms in
Drosophila. We have identified a Class II (secretin-related) G protein-coupled receptor (GPCR) that is specifically responsive to PDF and also to calcitonin-like peptides and to PACAP. In response to PDF, the PDF receptor (PDFR) elevates cAMP levels when expressed in HEK293 cells. As predicted by in vivo studies, cotransfection of
Neurofibromatosis Factor 1 significantly improves coupling of PDFR to adenylate cyclase.
pdfr mutant flies display increased circadian arrhythmicity, and also display altered geotaxis that is epistatic to that of
pdf mutants. PDFR immunosignals are expressed by diverse neurons, but only by a small subset of circadian pacemakers. These data establish the first synapse within the
Drosophila circadian neural circuit and underscore the importance of Class II peptide GPCR signaling in circadian neural systems.</description><subject>Adrenomedullin</subject><subject>Animals</subject><subject>Animals, Genetically Modified</subject><subject>Behavior</subject><subject>Behavior, Animal - physiology</subject><subject>Blotting, Western - methods</subject><subject>Brain - cytology</subject><subject>Brain - metabolism</subject><subject>Calcitonin - pharmacology</subject><subject>Cell Line</subject><subject>Circadian rhythm</subject><subject>Circadian Rhythm - physiology</subject><subject>Dose-Response Relationship, Drug</subject><subject>Drosophila</subject><subject>Drosophila Proteins - genetics</subject><subject>Drosophila Proteins - pharmacology</subject><subject>Drosophila Proteins - physiology</subject><subject>Gene Expression Regulation - physiology</subject><subject>Genes, Insect</subject><subject>Genomes</subject><subject>Humans</subject><subject>Immunohistochemistry - methods</subject><subject>Insects</subject><subject>Maze Learning</subject><subject>Motor Activity - genetics</subject><subject>Motor Activity - physiology</subject><subject>Mutagenesis - physiology</subject><subject>Mutation</subject><subject>Nerve Tissue Proteins - physiology</subject><subject>Neurons</subject><subject>Neurons - metabolism</subject><subject>Neuropeptides</subject><subject>Neuropeptides - pharmacology</subject><subject>Neuropeptides - physiology</subject><subject>Orientation - physiology</subject><subject>Peptides</subject><subject>Peptides - pharmacology</subject><subject>Proteins</subject><subject>ras GTPase-Activating Proteins - physiology</subject><subject>Receptors, G-Protein-Coupled - genetics</subject><subject>Receptors, G-Protein-Coupled - physiology</subject><subject>Reverse Transcriptase Polymerase Chain Reaction - methods</subject><subject>RNA, Messenger - biosynthesis</subject><subject>Rodents</subject><subject>Signal Transduction - drug effects</subject><subject>Signal Transduction - physiology</subject><subject>Transfection - methods</subject><subject>Transmitters</subject><subject>Variance analysis</subject><issn>0896-6273</issn><issn>1097-4199</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkU2LFDEURYMoTjv6D0QCgrsqX1JJVWUjOD3OKAwofmzchFTyZjpNddKTpAb896bpBsGFZvM2597APYS8ZNAyYP3bbRtwSTG0HEC2oFoA9YisGKihEUypx2QFo-qbng_dGXmW8xaACanYU3LGei64AL4iP79cXtGvaHFfYqLf_F0wsw931Ad6mWKO-42fDV3HUJKfloKZlkgvYtnQtU_WOG8CNcHRa4zF2OItvcCNefAx5efkya2ZM7443XPy4-rD9_XH5ubz9af1-5vGyo6VRk3GjY5zjrJ3g-hZfSi4gs7AhDgYNo2ddIMyBuQIzvYCwcnRqclONdmdkzfH3n2K9wvmonc-W5xnEzAuWffjwEWt-C_IYRiVkH0FX_8FbuOS6jJZMwldLyUbDnXiSNk6VE54q_fJ70z6pRnogyK91UdF-qBIg9JVUY29OpUv0w7dn9DJSQXeHQGsoz14TDpbj8Gi8wlt0S76f__wG61ao3g</recordid><startdate>20051020</startdate><enddate>20051020</enddate><creator>Mertens, Inge</creator><creator>Vandingenen, Anick</creator><creator>Johnson, Erik C.</creator><creator>Shafer, Orie T.</creator><creator>Li, W.</creator><creator>Trigg, J.S.</creator><creator>De Loof, Arnold</creator><creator>Schoofs, Liliane</creator><creator>Taghert, Paul H.</creator><general>Elsevier Inc</general><general>Elsevier Limited</general><scope>6I.</scope><scope>AAFTH</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>7QR</scope><scope>7TK</scope><scope>8FD</scope><scope>FR3</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>P64</scope><scope>RC3</scope><scope>7QG</scope><scope>7SS</scope><scope>7X8</scope></search><sort><creationdate>20051020</creationdate><title>PDF Receptor Signaling in Drosophila Contributes to Both Circadian and Geotactic Behaviors</title><author>Mertens, Inge ; Vandingenen, Anick ; Johnson, Erik C. ; Shafer, Orie T. ; Li, W. ; Trigg, J.S. ; De Loof, Arnold ; Schoofs, Liliane ; Taghert, Paul H.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c531t-9bad8d222e56d7461111e42903a0bee7a1b835d79aa0580dc64e0d58d9bcbd8d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>Adrenomedullin</topic><topic>Animals</topic><topic>Animals, Genetically Modified</topic><topic>Behavior</topic><topic>Behavior, Animal - physiology</topic><topic>Blotting, Western - methods</topic><topic>Brain - cytology</topic><topic>Brain - metabolism</topic><topic>Calcitonin - pharmacology</topic><topic>Cell Line</topic><topic>Circadian rhythm</topic><topic>Circadian Rhythm - physiology</topic><topic>Dose-Response Relationship, Drug</topic><topic>Drosophila</topic><topic>Drosophila Proteins - genetics</topic><topic>Drosophila Proteins - pharmacology</topic><topic>Drosophila Proteins - physiology</topic><topic>Gene Expression Regulation - physiology</topic><topic>Genes, Insect</topic><topic>Genomes</topic><topic>Humans</topic><topic>Immunohistochemistry - methods</topic><topic>Insects</topic><topic>Maze Learning</topic><topic>Motor Activity - genetics</topic><topic>Motor Activity - physiology</topic><topic>Mutagenesis - physiology</topic><topic>Mutation</topic><topic>Nerve Tissue Proteins - physiology</topic><topic>Neurons</topic><topic>Neurons - metabolism</topic><topic>Neuropeptides</topic><topic>Neuropeptides - pharmacology</topic><topic>Neuropeptides - physiology</topic><topic>Orientation - physiology</topic><topic>Peptides</topic><topic>Peptides - pharmacology</topic><topic>Proteins</topic><topic>ras GTPase-Activating Proteins - physiology</topic><topic>Receptors, G-Protein-Coupled - genetics</topic><topic>Receptors, G-Protein-Coupled - physiology</topic><topic>Reverse Transcriptase Polymerase Chain Reaction - methods</topic><topic>RNA, Messenger - biosynthesis</topic><topic>Rodents</topic><topic>Signal Transduction - drug effects</topic><topic>Signal Transduction - physiology</topic><topic>Transfection - methods</topic><topic>Transmitters</topic><topic>Variance analysis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Mertens, Inge</creatorcontrib><creatorcontrib>Vandingenen, Anick</creatorcontrib><creatorcontrib>Johnson, Erik C.</creatorcontrib><creatorcontrib>Shafer, Orie T.</creatorcontrib><creatorcontrib>Li, W.</creatorcontrib><creatorcontrib>Trigg, J.S.</creatorcontrib><creatorcontrib>De Loof, Arnold</creatorcontrib><creatorcontrib>Schoofs, Liliane</creatorcontrib><creatorcontrib>Taghert, Paul H.</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>Animal Behavior Abstracts</collection><collection>Entomology Abstracts (Full archive)</collection><collection>MEDLINE - Academic</collection><jtitle>Neuron (Cambridge, Mass.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Mertens, Inge</au><au>Vandingenen, Anick</au><au>Johnson, Erik C.</au><au>Shafer, Orie T.</au><au>Li, W.</au><au>Trigg, J.S.</au><au>De Loof, Arnold</au><au>Schoofs, Liliane</au><au>Taghert, Paul H.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>PDF Receptor Signaling in Drosophila Contributes to Both Circadian and Geotactic Behaviors</atitle><jtitle>Neuron (Cambridge, Mass.)</jtitle><addtitle>Neuron</addtitle><date>2005-10-20</date><risdate>2005</risdate><volume>48</volume><issue>2</issue><spage>213</spage><epage>219</epage><pages>213-219</pages><issn>0896-6273</issn><eissn>1097-4199</eissn><abstract>The neuropeptide Pigment-Dispersing Factor (PDF) is a principle transmitter regulating circadian locomotor rhythms in
Drosophila. We have identified a Class II (secretin-related) G protein-coupled receptor (GPCR) that is specifically responsive to PDF and also to calcitonin-like peptides and to PACAP. In response to PDF, the PDF receptor (PDFR) elevates cAMP levels when expressed in HEK293 cells. As predicted by in vivo studies, cotransfection of
Neurofibromatosis Factor 1 significantly improves coupling of PDFR to adenylate cyclase.
pdfr mutant flies display increased circadian arrhythmicity, and also display altered geotaxis that is epistatic to that of
pdf mutants. PDFR immunosignals are expressed by diverse neurons, but only by a small subset of circadian pacemakers. These data establish the first synapse within the
Drosophila circadian neural circuit and underscore the importance of Class II peptide GPCR signaling in circadian neural systems.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>16242402</pmid><doi>10.1016/j.neuron.2005.09.009</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; Cell Press Free Archives; Elsevier ScienceDirect Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
| subjects | Adrenomedullin Animals Animals, Genetically Modified Behavior Behavior, Animal - physiology Blotting, Western - methods Brain - cytology Brain - metabolism Calcitonin - pharmacology Cell Line Circadian rhythm Circadian Rhythm - physiology Dose-Response Relationship, Drug Drosophila Drosophila Proteins - genetics Drosophila Proteins - pharmacology Drosophila Proteins - physiology Gene Expression Regulation - physiology Genes, Insect Genomes Humans Immunohistochemistry - methods Insects Maze Learning Motor Activity - genetics Motor Activity - physiology Mutagenesis - physiology Mutation Nerve Tissue Proteins - physiology Neurons Neurons - metabolism Neuropeptides Neuropeptides - pharmacology Neuropeptides - physiology Orientation - physiology Peptides Peptides - pharmacology Proteins ras GTPase-Activating Proteins - physiology Receptors, G-Protein-Coupled - genetics Receptors, G-Protein-Coupled - physiology Reverse Transcriptase Polymerase Chain Reaction - methods RNA, Messenger - biosynthesis Rodents Signal Transduction - drug effects Signal Transduction - physiology Transfection - methods Transmitters Variance analysis |
| title | PDF Receptor Signaling in Drosophila Contributes to Both Circadian and Geotactic Behaviors |
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