Attenuating mutations in the P/C gene of human parainfluenza virus type 1 (HPIV1) vaccine candidates abrogate the inhibition of both induction and signaling of type I interferon (IFN) by wild-type HPIV1

Recombinant human parainfluenza virus type 1 (HPIV1) and mutants containing point and deletion (Δ) mutations in the P/C gene (r-C Δ10–15HN T553A, r-C R84G, r-C F170S and r-C Δ170), which have previously been evaluated as HPIV1 vaccine candidates, were evaluated for their effect on the type I interfe...

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Veröffentlicht in:	Virology (New York, N.Y.) N.Y.), 2006-08, Vol.352 (1), p.61-73
Hauptverfasser:	Van Cleve, William, Amaro-Carambot, Emerito, Surman, Sonja R., Bekisz, Joseph, Collins, Peter L., Zoon, Kathryn C., Murphy, Brian R., Skiadopoulos, Mario H., Bartlett, Emmalene J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Attenuating mutation Cell Line Cercopithecus aethiops Human parainfluenza virus Humans Interferon antagonist Interferon Type I - metabolism Parainfluenza Vaccines - genetics Parainfluenza Vaccines - immunology Parainfluenza Virus 1, Human - genetics Parainfluenza Virus 1, Human - immunology Parainfluenza Virus 1, Human - pathogenicity Phosphoproteins - genetics Phosphoproteins - immunology Point Mutation Signal Transduction Vaccine candidate Vaccines, Attenuated - genetics Vaccines, Attenuated - immunology Vero Cells Viral Proteins - genetics Viral Proteins - immunology
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