Prognostic significance of p53 mutation in suboptimally resected advanced ovarian carcinoma treated with the combination chemotherapy of paclitaxel and carboplatin

The prognostic significance of p53 mutation, microsattelite instability and DNA mismatch protein hMLH1 expression in suboptimally resected advanced ovarian carcinoma treated with the combination chemotherapy of paclitaxel and carboplatin was evaluated. The overall combination chemotherapy response r...

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Veröffentlicht in:	Cancer letters 2006-09, Vol.241 (2), p.289-300
Hauptverfasser:	Ueno, Yuko, Enomoto, Takayuki, Otsuki, Yoshiro, Sugita, Nagatoshi, Nakashima, Ryuichi, Yoshino, Kiyoshi, Kuragaki, Chie, Ueda, Yutaka, Aki, Tadaatsu, Ikegami, Hiromasa, Yamazaki, Masato, Ito, Kimihiko, Nagamatsu, Masaaki, Nishizaki, Takamichi, Asada, Masahiro, Kameda, Takashi, Wakimoto, Akinori, Mizutani, Takahiro, Yamada, Takako, Murata, Yuji
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenocarcinoma, Clear Cell - drug therapy Adenocarcinoma, Clear Cell - genetics Adenocarcinoma, Clear Cell - surgery Adenocarcinoma, Mucinous - drug therapy Adenocarcinoma, Mucinous - genetics Adenocarcinoma, Mucinous - surgery Adult Aged Antineoplastic Combined Chemotherapy Protocols - therapeutic use Apoptosis Cancer therapies Carboplatin Carboplatin - administration & dosage Carcinoma, Endometrioid - drug therapy Carcinoma, Endometrioid - genetics Carcinoma, Endometrioid - surgery Cell cycle Chemotherapy Cystadenocarcinoma, Serous - drug therapy Cystadenocarcinoma, Serous - genetics Cystadenocarcinoma, Serous - surgery Deoxyribonucleic acid DNA DNA damage Female Genes, p53 - genetics Genomes Humans Medical imaging Medical prognosis Microsatellite Repeats - drug effects Microsatellite Repeats - genetics Middle Aged Multivariate analysis Mutation Ovarian cancer Ovarian carcinoma Ovarian Neoplasms - drug therapy Ovarian Neoplasms - genetics Ovarian Neoplasms - surgery p53 Paclitaxel Paclitaxel - administration & dosage Prognosis Prospective Studies Surgery Survival Rate Tumors
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