Small-Dose Bupivacaine-Sufentanil Prevents Cardiac Output Modifications After Spinal Anesthesia
Spinal injection of small-dose (SD) bupivacaine decreases the likelihood of hypotension compared with large-dose (LD) bupivacaine. We assumed that a SD of bupivacaine could also prevent the decrease in cardiac output (CO). Patients undergoing elective urologic, lower abdominal, or lower limb surgery...
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| Veröffentlicht in: | Anesthesia and analgesia 2005-11, Vol.101 (5), p.1512-1515 |
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| creator | Asehnoune, Karim Larousse, Eric Tadié, Jean Marc Minville, Vincent Droupy, Stephane Benhamou, Dan |
| description | Spinal injection of small-dose (SD) bupivacaine decreases the likelihood of hypotension compared with large-dose (LD) bupivacaine. We assumed that a SD of bupivacaine could also prevent the decrease in cardiac output (CO). Patients undergoing elective urologic, lower abdominal, or lower limb surgery under spinal anesthesia were included in this prospective randomized study. Spinal injection consisted of 5 μg of sufentanil and either SD (7.5 mg of hyperbaric bupivacaine with glucosemonohydrate80 mg/mL; n = 19 patients) or LD (12.5 mg of hyperbaric bupivacaine with glucosemonohydrate80 mg/mL; n = 19 patients). CO (impedance cardiography), arterial blood pressure, and heart rate) were measured at 1 min before performance of spinal block and 2, 10, and 30 min after the intrathecal injection. Sensory level was also assessed at 30 min. CO was higher in the SD group as compared with the LD group from 2 min to 30 min after spinal anesthesia. Moreover, CO increased at 2 min in the SD group and decreased at 10 and 30 min in the LD group compared with baseline value. In conclusion, SD bupivacaine provides successful anesthesia and gives better CO stability than LD. |
| doi_str_mv | 10.1213/01.ANE.0000180996.91358.CC |
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We assumed that a SD of bupivacaine could also prevent the decrease in cardiac output (CO). Patients undergoing elective urologic, lower abdominal, or lower limb surgery under spinal anesthesia were included in this prospective randomized study. Spinal injection consisted of 5 μg of sufentanil and either SD (7.5 mg of hyperbaric bupivacaine with glucosemonohydrate80 mg/mL; n = 19 patients) or LD (12.5 mg of hyperbaric bupivacaine with glucosemonohydrate80 mg/mL; n = 19 patients). CO (impedance cardiography), arterial blood pressure, and heart rate) were measured at 1 min before performance of spinal block and 2, 10, and 30 min after the intrathecal injection. Sensory level was also assessed at 30 min. CO was higher in the SD group as compared with the LD group from 2 min to 30 min after spinal anesthesia. Moreover, CO increased at 2 min in the SD group and decreased at 10 and 30 min in the LD group compared with baseline value. In conclusion, SD bupivacaine provides successful anesthesia and gives better CO stability than LD.</description><identifier>ISSN: 0003-2999</identifier><identifier>EISSN: 1526-7598</identifier><identifier>DOI: 10.1213/01.ANE.0000180996.91358.CC</identifier><identifier>PMID: 16244022</identifier><identifier>CODEN: AACRAT</identifier><language>eng</language><publisher>Hagerstown, MD: International Anesthesia Research Society</publisher><subject>Adult ; Aged ; Anesthesia ; Anesthesia, Spinal - adverse effects ; Anesthesia. Intensive care medicine. Transfusions. 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We assumed that a SD of bupivacaine could also prevent the decrease in cardiac output (CO). Patients undergoing elective urologic, lower abdominal, or lower limb surgery under spinal anesthesia were included in this prospective randomized study. Spinal injection consisted of 5 μg of sufentanil and either SD (7.5 mg of hyperbaric bupivacaine with glucosemonohydrate80 mg/mL; n = 19 patients) or LD (12.5 mg of hyperbaric bupivacaine with glucosemonohydrate80 mg/mL; n = 19 patients). CO (impedance cardiography), arterial blood pressure, and heart rate) were measured at 1 min before performance of spinal block and 2, 10, and 30 min after the intrathecal injection. Sensory level was also assessed at 30 min. CO was higher in the SD group as compared with the LD group from 2 min to 30 min after spinal anesthesia. Moreover, CO increased at 2 min in the SD group and decreased at 10 and 30 min in the LD group compared with baseline value. In conclusion, SD bupivacaine provides successful anesthesia and gives better CO stability than LD.</description><subject>Adult</subject><subject>Aged</subject><subject>Anesthesia</subject><subject>Anesthesia, Spinal - adverse effects</subject><subject>Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy</subject><subject>Biological and medical sciences</subject><subject>Bupivacaine - administration & dosage</subject><subject>Cardiac Output - drug effects</subject><subject>Female</subject><subject>Heart Rate - drug effects</subject><subject>Humans</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Prospective Studies</subject><subject>Sufentanil - administration & dosage</subject><issn>0003-2999</issn><issn>1526-7598</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkF2P1CAUhonRuOPqXzCNid61coBS8G6s60eyuiaj1wQoZFCm7UK7G_-97M4kQ0IOJM973uRB6A3gBgjQ9xia7Y-rBpcDAkvJGwm0FU3fP0EbaAmvu1aKp2hTAFoTKeUFepHznwceC_4cXQAnjGFCNkjtDjrG-tOUXfVxncOdtjqMrt6t3o2LHkOsfiZ3V9656nUagrbVzbrM61J9n4bgg9VLmMZcbf3iUrWbw6hjtR1dXvYuB_0SPfM6ZvfqNC_R789Xv_qv9fXNl2_99rq2jDFek2EQBsBS0FhQbDrpnHADN9h3mHRGyI55ybnoOsMMN14aPkjTUjFwRoSgl-jdce-cptu1tKtDyNbFqEc3rVmVJMHAcAE_HEGbppyT82pO4aDTPwVYPehVGFTRq8561aNe1fcl_PrUspqDG87Rk88CvD0BOlsdfdKjDfnMdYSBpFA4duTup1i85b9xvXdJ7Z2Oy_6xGrdU1qQMgPKpy2Wc_gfBUpMk</recordid><startdate>20051101</startdate><enddate>20051101</enddate><creator>Asehnoune, Karim</creator><creator>Larousse, Eric</creator><creator>Tadié, Jean Marc</creator><creator>Minville, Vincent</creator><creator>Droupy, Stephane</creator><creator>Benhamou, Dan</creator><general>International Anesthesia Research Society</general><general>Lippincott</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20051101</creationdate><title>Small-Dose Bupivacaine-Sufentanil Prevents Cardiac Output Modifications After Spinal Anesthesia</title><author>Asehnoune, Karim ; Larousse, Eric ; Tadié, Jean Marc ; Minville, Vincent ; Droupy, Stephane ; Benhamou, Dan</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4446-2dd8b11c31a0830b79ee8ed6b0f7027b8974f966877b4b6bf9b6d9b538d642883</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Anesthesia</topic><topic>Anesthesia, Spinal - adverse effects</topic><topic>Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy</topic><topic>Biological and medical sciences</topic><topic>Bupivacaine - administration & dosage</topic><topic>Cardiac Output - drug effects</topic><topic>Female</topic><topic>Heart Rate - drug effects</topic><topic>Humans</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Prospective Studies</topic><topic>Sufentanil - administration & dosage</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Asehnoune, Karim</creatorcontrib><creatorcontrib>Larousse, Eric</creatorcontrib><creatorcontrib>Tadié, Jean Marc</creatorcontrib><creatorcontrib>Minville, Vincent</creatorcontrib><creatorcontrib>Droupy, Stephane</creatorcontrib><creatorcontrib>Benhamou, Dan</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Anesthesia and analgesia</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Asehnoune, Karim</au><au>Larousse, Eric</au><au>Tadié, Jean Marc</au><au>Minville, Vincent</au><au>Droupy, Stephane</au><au>Benhamou, Dan</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Small-Dose Bupivacaine-Sufentanil Prevents Cardiac Output Modifications After Spinal Anesthesia</atitle><jtitle>Anesthesia and analgesia</jtitle><addtitle>Anesth Analg</addtitle><date>2005-11-01</date><risdate>2005</risdate><volume>101</volume><issue>5</issue><spage>1512</spage><epage>1515</epage><pages>1512-1515</pages><issn>0003-2999</issn><eissn>1526-7598</eissn><coden>AACRAT</coden><abstract>Spinal injection of small-dose (SD) bupivacaine decreases the likelihood of hypotension compared with large-dose (LD) bupivacaine. We assumed that a SD of bupivacaine could also prevent the decrease in cardiac output (CO). Patients undergoing elective urologic, lower abdominal, or lower limb surgery under spinal anesthesia were included in this prospective randomized study. Spinal injection consisted of 5 μg of sufentanil and either SD (7.5 mg of hyperbaric bupivacaine with glucosemonohydrate80 mg/mL; n = 19 patients) or LD (12.5 mg of hyperbaric bupivacaine with glucosemonohydrate80 mg/mL; n = 19 patients). CO (impedance cardiography), arterial blood pressure, and heart rate) were measured at 1 min before performance of spinal block and 2, 10, and 30 min after the intrathecal injection. Sensory level was also assessed at 30 min. CO was higher in the SD group as compared with the LD group from 2 min to 30 min after spinal anesthesia. Moreover, CO increased at 2 min in the SD group and decreased at 10 and 30 min in the LD group compared with baseline value. In conclusion, SD bupivacaine provides successful anesthesia and gives better CO stability than LD.</abstract><cop>Hagerstown, MD</cop><pub>International Anesthesia Research Society</pub><pmid>16244022</pmid><doi>10.1213/01.ANE.0000180996.91358.CC</doi><tpages>4</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Adult Aged Anesthesia Anesthesia, Spinal - adverse effects Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy Biological and medical sciences Bupivacaine - administration & dosage Cardiac Output - drug effects Female Heart Rate - drug effects Humans Male Medical sciences Middle Aged Prospective Studies Sufentanil - administration & dosage |
| title | Small-Dose Bupivacaine-Sufentanil Prevents Cardiac Output Modifications After Spinal Anesthesia |
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