The Prevalence of CDKN2A Germ-Line Mutations and Relative Risk for Cutaneous Malignant Melanoma: An International Population-Based Study

Germ-line mutations of CDKN2A have been identified as strong risk factors for melanoma in studies of multiple-case families. However, an assessment of their relative risk for melanoma in the general population has been difficult because they occur infrequently. We addressed this issue using a novel...

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Veröffentlicht in:	Cancer epidemiology, biomarkers & prevention biomarkers & prevention, 2006-08, Vol.15 (8), p.1520-1525
Hauptverfasser:	BERWICK, Marianne, ORLOW, Irene, GALLAGHER, Richard P, DWYER, Terence, REBBECK, Timothy R, KANETSKY, Peter A, BUSAM, Klaus, FROM, Lynn, MUJUMDAR, Urvi, WILCOX, Homer, BEGG, Colin B, HUMMER, Amanda J, ARMSTRONG, Bruce K, KRICKER, Anne, MARRETT, Loraine D, MILLIKAN, Robert C, GRUBER, Stephen B, ANTON-CULVER, Hoda, ZANETTI, Roberto
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Australia - epidemiology Biological and medical sciences Canada - epidemiology Case-Control Studies Chromatography, High Pressure Liquid Cyclin-Dependent Kinase Inhibitor p16 - genetics Dermatology Exons - genetics Female Germ-Line Mutation Humans International Agencies Introns - genetics Italy - epidemiology Male Medical sciences Melanoma Melanoma - epidemiology Melanoma - genetics Middle Aged Neoplasms, Multiple Primary - epidemiology Neoplasms, Multiple Primary - genetics Organ Sites and Tumor Types Polymerase Chain Reaction Polymorphism, Genetic Skin Neoplasms - epidemiology Skin Neoplasms - genetics Tropical medicine Tumors Tumors of the skin and soft tissue. Premalignant lesions United States - epidemiology
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