Toxoplasma gondii Genotype Determines MyD88-Dependent Signaling in Infected Macrophages

Infection of mouse macrophages with Toxoplasma gondii elicits MAPK activation and IL-12 production, but host cell signaling pathways have not been clearly delineated. Here, we compared macrophage signaling in response to high virulence type I (RH) vs low virulence type II (ME49) strain infection. Ta...

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Veröffentlicht in:	Journal of Immunology 2006-08, Vol.177 (4), p.2584-2591
Hauptverfasser:	Kim, Leesun, Butcher, Barbara A, Lee, Chiang W, Uematsu, Satoshi, Akira, Shizuo, Denkers, Eric Y
Format:	Artikel
Sprache:	eng
Schlagworte:	Adaptor Proteins, Signal Transducing - physiology Animals Cell Line Cells, Cultured Enzyme Activation - immunology Female Genotype Immunity, Innate Interleukin-12 - biosynthesis Macrophages - enzymology Macrophages - immunology Macrophages - parasitology Mice Mice, Inbred C57BL Mice, Knockout Myeloid Differentiation Factor 88 p38 Mitogen-Activated Protein Kinases - metabolism Signal Transduction - immunology Species Specificity Toxoplasma - genetics Toxoplasma - isolation & purification Toxoplasma - pathogenicity Toxoplasma gondii Virulence
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