S100A1 Enhances the L-type Ca2+ Current in Embryonic Mouse and Neonatal Rat Ventricular Cardiomyocytes

S100A1 is an EF-hand type Ca2+-binding protein with a muscle-specific expression pattern. The highest S100A1 protein levels are found in cardiomyocytes, and it is expressed already at day 8 in the heart during embryonic development. Since S100A1 is known to be involved in the regulation of Ca2+ home...

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Veröffentlicht in:	The Journal of biological chemistry 2005-10, Vol.280 (43), p.36019-36028
Hauptverfasser:	Reppel, Michael, Sasse, Philipp, Piekorz, Roland, Tang, Ming, Roell, Wilhelm, Duan, Yaqi, Kletke, Anja, Hescheler, Jürgen, Nürnberg, Bernd, Fleischmann, Bernd K.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Calcium - metabolism Calcium Channels, L-Type - chemistry Calcium-Binding Proteins - metabolism Cells, Cultured Cyclic AMP - metabolism Cyclic AMP-Dependent Protein Kinases - metabolism Cytosol - metabolism Electrophysiology Endocytosis Kinetics Mice Muscles - cytology Myocytes, Cardiac - metabolism Protein Transport Rats Rats, Sprague-Dawley Rhodamines - pharmacology S100 Proteins Signal Transduction Spectrometry, Fluorescence Time Factors
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