Longitudinal study on quality of life in 102 survivors of childhood craniopharyngioma
We longitudinally analysed functional capacity and quality of life (QoL) in 102 patients with a childhood craniopharyngioma during follow-up. The Fertigkeitenskala Münster-Heidelberg (FMH) ability scale was used for QoL assessment. Multivariate analysis evaluated FMH scores at various time points, e...
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| Veröffentlicht in: | Child's nervous system 2005-11, Vol.21 (11), p.975-980 |
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| creator | Müller, Hermann L Bruhnken, Gina Emser, Angela Faldum, Andreas Etavard-Gorris, Nicole Gebhardt, Ursel Kolb, Reinhard Sörensen, Niels |
| description | We longitudinally analysed functional capacity and quality of life (QoL) in 102 patients with a childhood craniopharyngioma during follow-up.
The Fertigkeitenskala Münster-Heidelberg (FMH) ability scale was used for QoL assessment. Multivariate analysis evaluated FMH scores at various time points, examining hypothalamus involvement (HI), body mass index (BMI), degree of resection, tumour progression, relapse and irradiation.
Patients without HI (n=60) self-assessed higher QoL at baseline (p=0.001) and follow-up (p12 months after diagnosis showed longitudinal improvement in FMH scores (p=0.040). Rates of incomplete resection and irradiation were higher (p=0.070 and p=0.002 respectively) in patients with HI. In multivariate analysis, only HI, tumour relapse, progression, baseline FMH score, and time between diagnosis and baseline evaluation had independent impact on QoL. HI, tumour progression, and relapse had long-term QoL affects-most notably, severe obesity. |
| doi_str_mv | 10.1007/s00381-004-1124-y |
| format | Article |
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The Fertigkeitenskala Münster-Heidelberg (FMH) ability scale was used for QoL assessment. Multivariate analysis evaluated FMH scores at various time points, examining hypothalamus involvement (HI), body mass index (BMI), degree of resection, tumour progression, relapse and irradiation.
Patients without HI (n=60) self-assessed higher QoL at baseline (p=0.001) and follow-up (p<0.001) than patients with HI (n=42). Only patients without HI evaluated at baseline >12 months after diagnosis showed longitudinal improvement in FMH scores (p=0.040). Rates of incomplete resection and irradiation were higher (p=0.070 and p=0.002 respectively) in patients with HI. In multivariate analysis, only HI, tumour relapse, progression, baseline FMH score, and time between diagnosis and baseline evaluation had independent impact on QoL. HI, tumour progression, and relapse had long-term QoL affects-most notably, severe obesity.</description><identifier>ISSN: 0256-7040</identifier><identifier>EISSN: 1433-0350</identifier><identifier>DOI: 10.1007/s00381-004-1124-y</identifier><identifier>PMID: 16075216</identifier><language>eng</language><publisher>Germany</publisher><subject>Activities of Daily Living - classification ; Activities of Daily Living - psychology ; Adolescent ; Adult ; Body Mass Index ; Child ; Child, Preschool ; Combined Modality Therapy ; Craniopharyngioma - psychology ; Craniopharyngioma - radiotherapy ; Craniopharyngioma - surgery ; Disease Progression ; Female ; Follow-Up Studies ; Humans ; Hypophysectomy - psychology ; Hypothalamus - pathology ; Infant ; Longitudinal Studies ; Male ; Neoplasm Invasiveness ; Neoplasm Recurrence, Local - psychology ; Obesity - psychology ; Pituitary Irradiation ; Pituitary Neoplasms - psychology ; Pituitary Neoplasms - radiotherapy ; Pituitary Neoplasms - surgery ; Postoperative Complications - psychology ; Psychometrics - statistics & numerical data ; Quality of Life - psychology ; Radiotherapy, Adjuvant ; Reproducibility of Results ; Self-Assessment ; Sickness Impact Profile ; Survivors - psychology</subject><ispartof>Child's nervous system, 2005-11, Vol.21 (11), p.975-980</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c365t-d86c957217ede4ca38f65d19f1c5372e9e5551c6baa05021b007ba82bf5784093</citedby><cites>FETCH-LOGICAL-c365t-d86c957217ede4ca38f65d19f1c5372e9e5551c6baa05021b007ba82bf5784093</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16075216$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Müller, Hermann L</creatorcontrib><creatorcontrib>Bruhnken, Gina</creatorcontrib><creatorcontrib>Emser, Angela</creatorcontrib><creatorcontrib>Faldum, Andreas</creatorcontrib><creatorcontrib>Etavard-Gorris, Nicole</creatorcontrib><creatorcontrib>Gebhardt, Ursel</creatorcontrib><creatorcontrib>Kolb, Reinhard</creatorcontrib><creatorcontrib>Sörensen, Niels</creatorcontrib><title>Longitudinal study on quality of life in 102 survivors of childhood craniopharyngioma</title><title>Child's nervous system</title><addtitle>Childs Nerv Syst</addtitle><description>We longitudinally analysed functional capacity and quality of life (QoL) in 102 patients with a childhood craniopharyngioma during follow-up.
The Fertigkeitenskala Münster-Heidelberg (FMH) ability scale was used for QoL assessment. Multivariate analysis evaluated FMH scores at various time points, examining hypothalamus involvement (HI), body mass index (BMI), degree of resection, tumour progression, relapse and irradiation.
Patients without HI (n=60) self-assessed higher QoL at baseline (p=0.001) and follow-up (p<0.001) than patients with HI (n=42). Only patients without HI evaluated at baseline >12 months after diagnosis showed longitudinal improvement in FMH scores (p=0.040). Rates of incomplete resection and irradiation were higher (p=0.070 and p=0.002 respectively) in patients with HI. In multivariate analysis, only HI, tumour relapse, progression, baseline FMH score, and time between diagnosis and baseline evaluation had independent impact on QoL. HI, tumour progression, and relapse had long-term QoL affects-most notably, severe obesity.</description><subject>Activities of Daily Living - classification</subject><subject>Activities of Daily Living - psychology</subject><subject>Adolescent</subject><subject>Adult</subject><subject>Body Mass Index</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Combined Modality Therapy</subject><subject>Craniopharyngioma - psychology</subject><subject>Craniopharyngioma - radiotherapy</subject><subject>Craniopharyngioma - surgery</subject><subject>Disease Progression</subject><subject>Female</subject><subject>Follow-Up Studies</subject><subject>Humans</subject><subject>Hypophysectomy - psychology</subject><subject>Hypothalamus - pathology</subject><subject>Infant</subject><subject>Longitudinal Studies</subject><subject>Male</subject><subject>Neoplasm Invasiveness</subject><subject>Neoplasm Recurrence, Local - psychology</subject><subject>Obesity - psychology</subject><subject>Pituitary Irradiation</subject><subject>Pituitary Neoplasms - psychology</subject><subject>Pituitary Neoplasms - radiotherapy</subject><subject>Pituitary Neoplasms - surgery</subject><subject>Postoperative Complications - psychology</subject><subject>Psychometrics - statistics & numerical data</subject><subject>Quality of Life - psychology</subject><subject>Radiotherapy, Adjuvant</subject><subject>Reproducibility of Results</subject><subject>Self-Assessment</subject><subject>Sickness Impact Profile</subject><subject>Survivors - psychology</subject><issn>0256-7040</issn><issn>1433-0350</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkM1OwzAQhC0EoqXwAFxQTtwMu3ZsJ0dU8SdV4kLPluM41CiJ27iplLfHVStx2pF2ZrT7EXKP8IQA6jkC8AIpQE4RWU6nCzLHnHMKXMAlmQMTkirIYUZuYvwFQFGw8prMUIISDOWcrFeh__H7sfa9abOYxJSFPtuNpvX7JJus9Y3LfJ8hsCyOw8EfwhCPC7vxbb0Joc7sYHofthszTKksdOaWXDWmje7uPBdk_fb6vfygq6_3z-XLilouxZ7WhbSlUAyVq11uDS8aKWosG7SCK-ZKJ4RAKytjQADDKj1dmYJVjVBFDiVfkMdT73YIu9HFve58tK5tTe_CGLUsFEqFKhnxZLRDiHFwjd4Ovkv3agR9ZKlPLHViqY8s9ZQyD-fysepc_Z84w-N_CghvuA</recordid><startdate>20051101</startdate><enddate>20051101</enddate><creator>Müller, Hermann L</creator><creator>Bruhnken, Gina</creator><creator>Emser, Angela</creator><creator>Faldum, Andreas</creator><creator>Etavard-Gorris, Nicole</creator><creator>Gebhardt, Ursel</creator><creator>Kolb, Reinhard</creator><creator>Sörensen, Niels</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20051101</creationdate><title>Longitudinal study on quality of life in 102 survivors of childhood craniopharyngioma</title><author>Müller, Hermann L ; Bruhnken, Gina ; Emser, Angela ; Faldum, Andreas ; Etavard-Gorris, Nicole ; Gebhardt, Ursel ; Kolb, Reinhard ; Sörensen, Niels</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c365t-d86c957217ede4ca38f65d19f1c5372e9e5551c6baa05021b007ba82bf5784093</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>Activities of Daily Living - classification</topic><topic>Activities of Daily Living - psychology</topic><topic>Adolescent</topic><topic>Adult</topic><topic>Body Mass Index</topic><topic>Child</topic><topic>Child, Preschool</topic><topic>Combined Modality Therapy</topic><topic>Craniopharyngioma - psychology</topic><topic>Craniopharyngioma - radiotherapy</topic><topic>Craniopharyngioma - surgery</topic><topic>Disease Progression</topic><topic>Female</topic><topic>Follow-Up Studies</topic><topic>Humans</topic><topic>Hypophysectomy - psychology</topic><topic>Hypothalamus - pathology</topic><topic>Infant</topic><topic>Longitudinal Studies</topic><topic>Male</topic><topic>Neoplasm Invasiveness</topic><topic>Neoplasm Recurrence, Local - psychology</topic><topic>Obesity - psychology</topic><topic>Pituitary Irradiation</topic><topic>Pituitary Neoplasms - psychology</topic><topic>Pituitary Neoplasms - radiotherapy</topic><topic>Pituitary Neoplasms - surgery</topic><topic>Postoperative Complications - psychology</topic><topic>Psychometrics - statistics & numerical data</topic><topic>Quality of Life - psychology</topic><topic>Radiotherapy, Adjuvant</topic><topic>Reproducibility of Results</topic><topic>Self-Assessment</topic><topic>Sickness Impact Profile</topic><topic>Survivors - psychology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Müller, Hermann L</creatorcontrib><creatorcontrib>Bruhnken, Gina</creatorcontrib><creatorcontrib>Emser, Angela</creatorcontrib><creatorcontrib>Faldum, Andreas</creatorcontrib><creatorcontrib>Etavard-Gorris, Nicole</creatorcontrib><creatorcontrib>Gebhardt, Ursel</creatorcontrib><creatorcontrib>Kolb, Reinhard</creatorcontrib><creatorcontrib>Sörensen, Niels</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Child's nervous system</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Müller, Hermann L</au><au>Bruhnken, Gina</au><au>Emser, Angela</au><au>Faldum, Andreas</au><au>Etavard-Gorris, Nicole</au><au>Gebhardt, Ursel</au><au>Kolb, Reinhard</au><au>Sörensen, Niels</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Longitudinal study on quality of life in 102 survivors of childhood craniopharyngioma</atitle><jtitle>Child's nervous system</jtitle><addtitle>Childs Nerv Syst</addtitle><date>2005-11-01</date><risdate>2005</risdate><volume>21</volume><issue>11</issue><spage>975</spage><epage>980</epage><pages>975-980</pages><issn>0256-7040</issn><eissn>1433-0350</eissn><abstract>We longitudinally analysed functional capacity and quality of life (QoL) in 102 patients with a childhood craniopharyngioma during follow-up.
The Fertigkeitenskala Münster-Heidelberg (FMH) ability scale was used for QoL assessment. Multivariate analysis evaluated FMH scores at various time points, examining hypothalamus involvement (HI), body mass index (BMI), degree of resection, tumour progression, relapse and irradiation.
Patients without HI (n=60) self-assessed higher QoL at baseline (p=0.001) and follow-up (p<0.001) than patients with HI (n=42). Only patients without HI evaluated at baseline >12 months after diagnosis showed longitudinal improvement in FMH scores (p=0.040). Rates of incomplete resection and irradiation were higher (p=0.070 and p=0.002 respectively) in patients with HI. In multivariate analysis, only HI, tumour relapse, progression, baseline FMH score, and time between diagnosis and baseline evaluation had independent impact on QoL. HI, tumour progression, and relapse had long-term QoL affects-most notably, severe obesity.</abstract><cop>Germany</cop><pmid>16075216</pmid><doi>10.1007/s00381-004-1124-y</doi><tpages>6</tpages></addata></record> |
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| subjects | Activities of Daily Living - classification Activities of Daily Living - psychology Adolescent Adult Body Mass Index Child Child, Preschool Combined Modality Therapy Craniopharyngioma - psychology Craniopharyngioma - radiotherapy Craniopharyngioma - surgery Disease Progression Female Follow-Up Studies Humans Hypophysectomy - psychology Hypothalamus - pathology Infant Longitudinal Studies Male Neoplasm Invasiveness Neoplasm Recurrence, Local - psychology Obesity - psychology Pituitary Irradiation Pituitary Neoplasms - psychology Pituitary Neoplasms - radiotherapy Pituitary Neoplasms - surgery Postoperative Complications - psychology Psychometrics - statistics & numerical data Quality of Life - psychology Radiotherapy, Adjuvant Reproducibility of Results Self-Assessment Sickness Impact Profile Survivors - psychology |
| title | Longitudinal study on quality of life in 102 survivors of childhood craniopharyngioma |
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