Interindividual variability of once-daily ritonavir boosted saquinavir pharmacokinetics in Thai and UK patients

Objectives: Differential exposure to saquinavir/ritonavir may lead to therapy failure. The objective was to identify factors that influence variability of saquinavir/ritonavir plasma concentrations. Methods: Saquinavir/ritonavir data, dosed as 1600/100 mg once daily, from three separate pharmacokine...

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Veröffentlicht in:	Journal of antimicrobial chemotherapy 2005-11, Vol.56 (5), p.908-913
Hauptverfasser:	Autar, Reshma Saskia, Boffito, Marta, Hassink, Elly, Wit, Ferdinand W. N. M., Ananworanich, Jintanat, Siangphoe, Umaporn, Pozniak, Anton, Cooper, David A., Phanuphak, Praphan, Lange, Joep M. A., Ruxrungtham, Kiat, Burger, David M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Analysis of Variance Antibiotics. Antiinfectious agents. Antiparasitic agents Area Under Curve Biological and medical sciences Body Mass Index Body Weight clinical pharmacology Drug Therapy, Combination Female Geography HIV HIV Infections - drug therapy HIV Protease Inhibitors - administration & dosage HIV Protease Inhibitors - blood HIV Protease Inhibitors - pharmacokinetics Human viral diseases Humans Immunodeficiencies Immunodeficiencies. Immunoglobulinopathies Immunopathology Infectious diseases Male Medical sciences Middle Aged Multivariate Analysis Pharmacology. Drug treatments protease inhibitors Ritonavir - administration & dosage Ritonavir - blood Ritonavir - pharmacokinetics Saquinavir - administration & dosage Saquinavir - blood Saquinavir - pharmacokinetics Sex Characteristics Thailand United Kingdom Viral diseases Viral diseases of the lymphoid tissue and the blood. Aids
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