B2707 differs in peptide specificity from B2705 and B2704 as much as from HLA‐B27 subtypes not associated to spondyloarthritis

HLA‐B*2707 is associated with ankylosing spondylitis in most populations. Like the non‐associated allotypes B*2706 and B*2709, it lacks Asp116 and shows preference for peptides with nonpolar C‐terminal residues. The relationships between the peptide specificity of B*2707 and those of the disease‐ass...

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Veröffentlicht in:	European Journal of Immunology 2006-07, Vol.36 (7), p.1867-1881
Hauptverfasser:	Gómez, Patricia, Montserrat, Verónica, Marcilla, Miguel, Paradela, Alberto, de Castro, José A. López
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Motifs Ankylosing spondylitis Cell Line Epitopes, T-Lymphocyte - immunology Epitopes, T-Lymphocyte - metabolism HLA-B Antigens - immunology HLA-B Antigens - metabolism HLA-B27 Antigen - immunology HLA-B27 Antigen - metabolism HLA‐B27 Humans Peptides Peptides - immunology Peptides - metabolism Protein Binding Spondylarthritis - immunology Spondylarthritis - metabolism T-Lymphocytes, Cytotoxic - immunology T-Lymphocytes, Cytotoxic - metabolism
Online-Zugang:	Volltext
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