Synthetic, self-assembly ABCD nanoparticles; a structural paradigm for viable synthetic non-viral vectors

Gene therapy research is still in trouble owing to a paucity of acceptable vector systems to deliver nucleic acids to patients for therapy. Viral vectors are efficient but may be too dangerous. Synthetic non-viral vectors are inherently safer but are currently not efficient enough to be clinically v...

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Veröffentlicht in:	Chemical Society reviews 2005-11, Vol.34 (11), p.970-994
Hauptverfasser:	Kostarelos, Kostas, Miller, Andrew D
Format:	Artikel
Sprache:	eng
Schlagworte:	Cations - chemistry DNA - chemistry Genetic Therapy - methods Genetic Vectors - chemical synthesis Humans Liposomes - chemistry Micelles Models, Biological Models, Molecular Molecular Structure Nanostructures - chemistry
Online-Zugang:	Volltext
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