Prognostic significance of glycaemic control in patients with HBV and HCV-related cirrhosis and diabetes mellitus
Aims Diabetes mellitus (DM) is frequently observed in patients with cirrhosis, particularly that due to hepatitis C virus (HCV) infection. However, no studies have focused on the clinical significance of glycaemic control in cirrhotic patients because of their short life expectancy and poor hepatic...
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| Veröffentlicht in: | Diabetic medicine 2005-11, Vol.22 (11), p.1530-1535 |
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| creator | Kwon, S. Y. Kim, S. S. Kwon, O. S. Kwon, K. A. Chung, M. G. Park, D. K. Kim, Y. S. Koo, Y. S. Kim, Y. K. Choi, D. J. Kim, J. H. |
| description | Aims Diabetes mellitus (DM) is frequently observed in patients with cirrhosis, particularly that due to hepatitis C virus (HCV) infection. However, no studies have focused on the clinical significance of glycaemic control in cirrhotic patients because of their short life expectancy and poor hepatic function. The aim of this study was to evaluate the prognostic impact of glycaemic control in patients with hepatitis B virus (HBV) and HCV‐related cirrhosis and DM.
Methods A total of 434 patients with HCV‐related (HCV group, n = 88) or HBV‐related (HBV group, n = 346) cirrhosis were studied retrospectively. We determined the prevalence of DM and treatment methods for hyperglycaemia and status of glycaemic control, and the patients’ outcome.
Results The prevalence of DM was 43.2% (38/88) in the HCV group and 19.7% (68/346) in the HBV group. Patients in the HCV group were older with a female preponderance. DM was detected before the diagnosis of cirrhosis or simultaneously in 92% and 79% in the HCV and HBV groups, respectively. Most patients were treated with insulin or oral hypoglycaemic agents. However, blood glucose levels were maintained within the normal range in 34.2% of the HCV group and in 23.5% of the HBV group. Forty‐six patients died during the observation period in both groups. Hepatic failure was the most common cause of death, and sepsis and variceal bleeding were more frequent in the HCV group than in the HBV group. Multivariate analysis showed that Child–Pugh class was the most important factor for survival in both groups. In the HCV group, the status of glycaemic control was a significant independent factor of survival (P = 0.018). In the HBV group, age and the development of spontaneous bacterial peritonitis were significant.
Conclusion DM is more frequent in patients with HCV‐related cirrhosis than in patients with HBV. Strict control of blood glucose levels could improve survival in HCV patients. A precise assessment of the risks and benefits of glycaemic control is required to reduce the mortality and morbidity of patients with cirrhosis and DM. |
| doi_str_mv | 10.1111/j.1464-5491.2005.01687.x |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_68714648</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>68714648</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4667-2ba253582942b85872e01e9ba0d23fddeaf73de7f8ad0f0d552b292e32df608c3</originalsourceid><addsrcrecordid>eNqNkUtvEzEUhUcIREPhLyBvYDeDHzNjz4IFpKVB6gMEFKkby2Nfpw7zSG1HTf49niZql-CNLZ3vXF-dk2WI4IKk82FVkLIu86psSEExrgpMasGL7bNs9ig8z2aYlzRnmJOj7FUIK4wJbVjzMjsiNS1JQ8Qsu_vmx-Uwhug0Cm45OOu0GjSg0aJlt9MK-qTocYh-7JAb0FpFB0MM6N7FW7T4fI3UYNBifp176FQEg7Tz_nYMLjwoxqkWIgTUQ9e5uAmvsxdWdQHeHO7j7NeX05_zRX5-dfZ1_uk812Vd85y2ilasErQpaSsqwSlgAk2rsKHMGgPKcmaAW6EMtthUFW1pQ4FRY2ssNDvO3u_nrv14t4EQZe-CTkuoAcZNkCmwKSvxT5A0glImaALFHtR-DMGDlWvveuV3kmA59SJXchopp_jl1It86EVuk_Xt4Y9N24N5Mh6KSMC7A6CCVp31qQQXnjhOaYlJk7iPe-7edbD77wXkycXp9Er-fO93IcL20a_8H1lzxiv5-_IsmW7ID3JxI7-zv_zxuOY</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>19822382</pqid></control><display><type>article</type><title>Prognostic significance of glycaemic control in patients with HBV and HCV-related cirrhosis and diabetes mellitus</title><source>MEDLINE</source><source>Access via Wiley Online Library</source><creator>Kwon, S. Y. ; Kim, S. S. ; Kwon, O. S. ; Kwon, K. A. ; Chung, M. G. ; Park, D. K. ; Kim, Y. S. ; Koo, Y. S. ; Kim, Y. K. ; Choi, D. J. ; Kim, J. H.</creator><creatorcontrib>Kwon, S. Y. ; Kim, S. S. ; Kwon, O. S. ; Kwon, K. A. ; Chung, M. G. ; Park, D. K. ; Kim, Y. S. ; Koo, Y. S. ; Kim, Y. K. ; Choi, D. J. ; Kim, J. H.</creatorcontrib><description>Aims Diabetes mellitus (DM) is frequently observed in patients with cirrhosis, particularly that due to hepatitis C virus (HCV) infection. However, no studies have focused on the clinical significance of glycaemic control in cirrhotic patients because of their short life expectancy and poor hepatic function. The aim of this study was to evaluate the prognostic impact of glycaemic control in patients with hepatitis B virus (HBV) and HCV‐related cirrhosis and DM.
Methods A total of 434 patients with HCV‐related (HCV group, n = 88) or HBV‐related (HBV group, n = 346) cirrhosis were studied retrospectively. We determined the prevalence of DM and treatment methods for hyperglycaemia and status of glycaemic control, and the patients’ outcome.
Results The prevalence of DM was 43.2% (38/88) in the HCV group and 19.7% (68/346) in the HBV group. Patients in the HCV group were older with a female preponderance. DM was detected before the diagnosis of cirrhosis or simultaneously in 92% and 79% in the HCV and HBV groups, respectively. Most patients were treated with insulin or oral hypoglycaemic agents. However, blood glucose levels were maintained within the normal range in 34.2% of the HCV group and in 23.5% of the HBV group. Forty‐six patients died during the observation period in both groups. Hepatic failure was the most common cause of death, and sepsis and variceal bleeding were more frequent in the HCV group than in the HBV group. Multivariate analysis showed that Child–Pugh class was the most important factor for survival in both groups. In the HCV group, the status of glycaemic control was a significant independent factor of survival (P = 0.018). In the HBV group, age and the development of spontaneous bacterial peritonitis were significant.
Conclusion DM is more frequent in patients with HCV‐related cirrhosis than in patients with HBV. Strict control of blood glucose levels could improve survival in HCV patients. A precise assessment of the risks and benefits of glycaemic control is required to reduce the mortality and morbidity of patients with cirrhosis and DM.</description><identifier>ISSN: 0742-3071</identifier><identifier>EISSN: 1464-5491</identifier><identifier>DOI: 10.1111/j.1464-5491.2005.01687.x</identifier><identifier>PMID: 16241918</identifier><identifier>CODEN: DIMEEV</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Science Ltd</publisher><subject>Adult ; Aged ; Biological and medical sciences ; Blood Glucose - analysis ; cirrhosis ; diabetes mellitus ; Diabetes Mellitus - prevention & control ; Diabetes Mellitus - virology ; Diabetes. Impaired glucose tolerance ; Endocrine pancreas. Apud cells (diseases) ; Endocrinopathies ; Etiopathogenesis. Screening. Investigations. Target tissue resistance ; Female ; Gastroenterology. Liver. Pancreas. Abdomen ; Hepatitis B - complications ; Hepatitis B virus ; hepatitis C ; Hepatitis C - complications ; Hepatitis C virus ; Humans ; Hyperglycemia - prevention & control ; Hyperglycemia - virology ; Liver Cirrhosis - virology ; Liver. Biliary tract. Portal circulation. Exocrine pancreas ; Male ; Medical sciences ; Middle Aged ; Other diseases. Semiology ; Prognosis ; Retrospective Studies</subject><ispartof>Diabetic medicine, 2005-11, Vol.22 (11), p.1530-1535</ispartof><rights>2005 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4667-2ba253582942b85872e01e9ba0d23fddeaf73de7f8ad0f0d552b292e32df608c3</citedby><cites>FETCH-LOGICAL-c4667-2ba253582942b85872e01e9ba0d23fddeaf73de7f8ad0f0d552b292e32df608c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fj.1464-5491.2005.01687.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fj.1464-5491.2005.01687.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=17224019$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16241918$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kwon, S. Y.</creatorcontrib><creatorcontrib>Kim, S. S.</creatorcontrib><creatorcontrib>Kwon, O. S.</creatorcontrib><creatorcontrib>Kwon, K. A.</creatorcontrib><creatorcontrib>Chung, M. G.</creatorcontrib><creatorcontrib>Park, D. K.</creatorcontrib><creatorcontrib>Kim, Y. S.</creatorcontrib><creatorcontrib>Koo, Y. S.</creatorcontrib><creatorcontrib>Kim, Y. K.</creatorcontrib><creatorcontrib>Choi, D. J.</creatorcontrib><creatorcontrib>Kim, J. H.</creatorcontrib><title>Prognostic significance of glycaemic control in patients with HBV and HCV-related cirrhosis and diabetes mellitus</title><title>Diabetic medicine</title><addtitle>Diabet Med</addtitle><description>Aims Diabetes mellitus (DM) is frequently observed in patients with cirrhosis, particularly that due to hepatitis C virus (HCV) infection. However, no studies have focused on the clinical significance of glycaemic control in cirrhotic patients because of their short life expectancy and poor hepatic function. The aim of this study was to evaluate the prognostic impact of glycaemic control in patients with hepatitis B virus (HBV) and HCV‐related cirrhosis and DM.
Methods A total of 434 patients with HCV‐related (HCV group, n = 88) or HBV‐related (HBV group, n = 346) cirrhosis were studied retrospectively. We determined the prevalence of DM and treatment methods for hyperglycaemia and status of glycaemic control, and the patients’ outcome.
Results The prevalence of DM was 43.2% (38/88) in the HCV group and 19.7% (68/346) in the HBV group. Patients in the HCV group were older with a female preponderance. DM was detected before the diagnosis of cirrhosis or simultaneously in 92% and 79% in the HCV and HBV groups, respectively. Most patients were treated with insulin or oral hypoglycaemic agents. However, blood glucose levels were maintained within the normal range in 34.2% of the HCV group and in 23.5% of the HBV group. Forty‐six patients died during the observation period in both groups. Hepatic failure was the most common cause of death, and sepsis and variceal bleeding were more frequent in the HCV group than in the HBV group. Multivariate analysis showed that Child–Pugh class was the most important factor for survival in both groups. In the HCV group, the status of glycaemic control was a significant independent factor of survival (P = 0.018). In the HBV group, age and the development of spontaneous bacterial peritonitis were significant.
Conclusion DM is more frequent in patients with HCV‐related cirrhosis than in patients with HBV. Strict control of blood glucose levels could improve survival in HCV patients. A precise assessment of the risks and benefits of glycaemic control is required to reduce the mortality and morbidity of patients with cirrhosis and DM.</description><subject>Adult</subject><subject>Aged</subject><subject>Biological and medical sciences</subject><subject>Blood Glucose - analysis</subject><subject>cirrhosis</subject><subject>diabetes mellitus</subject><subject>Diabetes Mellitus - prevention & control</subject><subject>Diabetes Mellitus - virology</subject><subject>Diabetes. Impaired glucose tolerance</subject><subject>Endocrine pancreas. Apud cells (diseases)</subject><subject>Endocrinopathies</subject><subject>Etiopathogenesis. Screening. Investigations. Target tissue resistance</subject><subject>Female</subject><subject>Gastroenterology. Liver. Pancreas. Abdomen</subject><subject>Hepatitis B - complications</subject><subject>Hepatitis B virus</subject><subject>hepatitis C</subject><subject>Hepatitis C - complications</subject><subject>Hepatitis C virus</subject><subject>Humans</subject><subject>Hyperglycemia - prevention & control</subject><subject>Hyperglycemia - virology</subject><subject>Liver Cirrhosis - virology</subject><subject>Liver. Biliary tract. Portal circulation. Exocrine pancreas</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Other diseases. Semiology</subject><subject>Prognosis</subject><subject>Retrospective Studies</subject><issn>0742-3071</issn><issn>1464-5491</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkUtvEzEUhUcIREPhLyBvYDeDHzNjz4IFpKVB6gMEFKkby2Nfpw7zSG1HTf49niZql-CNLZ3vXF-dk2WI4IKk82FVkLIu86psSEExrgpMasGL7bNs9ig8z2aYlzRnmJOj7FUIK4wJbVjzMjsiNS1JQ8Qsu_vmx-Uwhug0Cm45OOu0GjSg0aJlt9MK-qTocYh-7JAb0FpFB0MM6N7FW7T4fI3UYNBifp176FQEg7Tz_nYMLjwoxqkWIgTUQ9e5uAmvsxdWdQHeHO7j7NeX05_zRX5-dfZ1_uk812Vd85y2ilasErQpaSsqwSlgAk2rsKHMGgPKcmaAW6EMtthUFW1pQ4FRY2ssNDvO3u_nrv14t4EQZe-CTkuoAcZNkCmwKSvxT5A0glImaALFHtR-DMGDlWvveuV3kmA59SJXchopp_jl1It86EVuk_Xt4Y9N24N5Mh6KSMC7A6CCVp31qQQXnjhOaYlJk7iPe-7edbD77wXkycXp9Er-fO93IcL20a_8H1lzxiv5-_IsmW7ID3JxI7-zv_zxuOY</recordid><startdate>200511</startdate><enddate>200511</enddate><creator>Kwon, S. Y.</creator><creator>Kim, S. S.</creator><creator>Kwon, O. S.</creator><creator>Kwon, K. A.</creator><creator>Chung, M. G.</creator><creator>Park, D. K.</creator><creator>Kim, Y. S.</creator><creator>Koo, Y. S.</creator><creator>Kim, Y. K.</creator><creator>Choi, D. J.</creator><creator>Kim, J. H.</creator><general>Blackwell Science Ltd</general><general>Blackwell</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QL</scope><scope>7U9</scope><scope>C1K</scope><scope>H94</scope><scope>7X8</scope></search><sort><creationdate>200511</creationdate><title>Prognostic significance of glycaemic control in patients with HBV and HCV-related cirrhosis and diabetes mellitus</title><author>Kwon, S. Y. ; Kim, S. S. ; Kwon, O. S. ; Kwon, K. A. ; Chung, M. G. ; Park, D. K. ; Kim, Y. S. ; Koo, Y. S. ; Kim, Y. K. ; Choi, D. J. ; Kim, J. H.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4667-2ba253582942b85872e01e9ba0d23fddeaf73de7f8ad0f0d552b292e32df608c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Biological and medical sciences</topic><topic>Blood Glucose - analysis</topic><topic>cirrhosis</topic><topic>diabetes mellitus</topic><topic>Diabetes Mellitus - prevention & control</topic><topic>Diabetes Mellitus - virology</topic><topic>Diabetes. Impaired glucose tolerance</topic><topic>Endocrine pancreas. Apud cells (diseases)</topic><topic>Endocrinopathies</topic><topic>Etiopathogenesis. Screening. Investigations. Target tissue resistance</topic><topic>Female</topic><topic>Gastroenterology. Liver. Pancreas. Abdomen</topic><topic>Hepatitis B - complications</topic><topic>Hepatitis B virus</topic><topic>hepatitis C</topic><topic>Hepatitis C - complications</topic><topic>Hepatitis C virus</topic><topic>Humans</topic><topic>Hyperglycemia - prevention & control</topic><topic>Hyperglycemia - virology</topic><topic>Liver Cirrhosis - virology</topic><topic>Liver. Biliary tract. Portal circulation. Exocrine pancreas</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Other diseases. Semiology</topic><topic>Prognosis</topic><topic>Retrospective Studies</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kwon, S. Y.</creatorcontrib><creatorcontrib>Kim, S. S.</creatorcontrib><creatorcontrib>Kwon, O. S.</creatorcontrib><creatorcontrib>Kwon, K. A.</creatorcontrib><creatorcontrib>Chung, M. G.</creatorcontrib><creatorcontrib>Park, D. K.</creatorcontrib><creatorcontrib>Kim, Y. S.</creatorcontrib><creatorcontrib>Koo, Y. S.</creatorcontrib><creatorcontrib>Kim, Y. K.</creatorcontrib><creatorcontrib>Choi, D. J.</creatorcontrib><creatorcontrib>Kim, J. H.</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Virology and AIDS Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Diabetic medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kwon, S. Y.</au><au>Kim, S. S.</au><au>Kwon, O. S.</au><au>Kwon, K. A.</au><au>Chung, M. G.</au><au>Park, D. K.</au><au>Kim, Y. S.</au><au>Koo, Y. S.</au><au>Kim, Y. K.</au><au>Choi, D. J.</au><au>Kim, J. H.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Prognostic significance of glycaemic control in patients with HBV and HCV-related cirrhosis and diabetes mellitus</atitle><jtitle>Diabetic medicine</jtitle><addtitle>Diabet Med</addtitle><date>2005-11</date><risdate>2005</risdate><volume>22</volume><issue>11</issue><spage>1530</spage><epage>1535</epage><pages>1530-1535</pages><issn>0742-3071</issn><eissn>1464-5491</eissn><coden>DIMEEV</coden><abstract>Aims Diabetes mellitus (DM) is frequently observed in patients with cirrhosis, particularly that due to hepatitis C virus (HCV) infection. However, no studies have focused on the clinical significance of glycaemic control in cirrhotic patients because of their short life expectancy and poor hepatic function. The aim of this study was to evaluate the prognostic impact of glycaemic control in patients with hepatitis B virus (HBV) and HCV‐related cirrhosis and DM.
Methods A total of 434 patients with HCV‐related (HCV group, n = 88) or HBV‐related (HBV group, n = 346) cirrhosis were studied retrospectively. We determined the prevalence of DM and treatment methods for hyperglycaemia and status of glycaemic control, and the patients’ outcome.
Results The prevalence of DM was 43.2% (38/88) in the HCV group and 19.7% (68/346) in the HBV group. Patients in the HCV group were older with a female preponderance. DM was detected before the diagnosis of cirrhosis or simultaneously in 92% and 79% in the HCV and HBV groups, respectively. Most patients were treated with insulin or oral hypoglycaemic agents. However, blood glucose levels were maintained within the normal range in 34.2% of the HCV group and in 23.5% of the HBV group. Forty‐six patients died during the observation period in both groups. Hepatic failure was the most common cause of death, and sepsis and variceal bleeding were more frequent in the HCV group than in the HBV group. Multivariate analysis showed that Child–Pugh class was the most important factor for survival in both groups. In the HCV group, the status of glycaemic control was a significant independent factor of survival (P = 0.018). In the HBV group, age and the development of spontaneous bacterial peritonitis were significant.
Conclusion DM is more frequent in patients with HCV‐related cirrhosis than in patients with HBV. Strict control of blood glucose levels could improve survival in HCV patients. A precise assessment of the risks and benefits of glycaemic control is required to reduce the mortality and morbidity of patients with cirrhosis and DM.</abstract><cop>Oxford, UK</cop><pub>Blackwell Science Ltd</pub><pmid>16241918</pmid><doi>10.1111/j.1464-5491.2005.01687.x</doi><tpages>6</tpages></addata></record> |
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| subjects | Adult Aged Biological and medical sciences Blood Glucose - analysis cirrhosis diabetes mellitus Diabetes Mellitus - prevention & control Diabetes Mellitus - virology Diabetes. Impaired glucose tolerance Endocrine pancreas. Apud cells (diseases) Endocrinopathies Etiopathogenesis. Screening. Investigations. Target tissue resistance Female Gastroenterology. Liver. Pancreas. Abdomen Hepatitis B - complications Hepatitis B virus hepatitis C Hepatitis C - complications Hepatitis C virus Humans Hyperglycemia - prevention & control Hyperglycemia - virology Liver Cirrhosis - virology Liver. Biliary tract. Portal circulation. Exocrine pancreas Male Medical sciences Middle Aged Other diseases. Semiology Prognosis Retrospective Studies |
| title | Prognostic significance of glycaemic control in patients with HBV and HCV-related cirrhosis and diabetes mellitus |
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