Calcium Influx through Channels Other than Voltage-Dependent Calcium Channels Is Critical to the Pituitary Adenylate Cyclase-Activating Polypeptide-Induced Increase in Excitability in Guinea Pig Cardiac Neurons
: Pituitary adenylate cyclase‐activating polypeptide (PACAP) effects on intracellular calcium ([Ca2+]i) and excitability have been studied in adult guinea pig intracardiac neurons. PACAP increased excitability, but did not elicit Ca2+ release from intracellular stores. Exposure to a Ca2+‐deficient...
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| Veröffentlicht in: | Annals of the New York Academy of Sciences 2006-07, Vol.1070 (1), p.317-321 |
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| container_title | Annals of the New York Academy of Sciences |
| container_volume | 1070 |
| creator | HARDWICK, JEAN C. TOMPKINS, JOHN D. LOCKNAR, SARAH A. MERRIAM, LAURA A. YOUNG, BETH A. PARSONS, RODNEY L. |
| description | : Pituitary adenylate cyclase‐activating polypeptide (PACAP) effects on intracellular calcium ([Ca2+]i) and excitability have been studied in adult guinea pig intracardiac neurons. PACAP increased excitability, but did not elicit Ca2+ release from intracellular stores. Exposure to a Ca2+‐deficient solution did not deplete [Ca2+]i stores but did eliminate the PACAP‐induced increase in excitability. We postulate that Ca2+ influx is required for the PACAP‐induced increase in excitability. |
| doi_str_mv | 10.1196/annals.1317.036 |
| format | Article |
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PACAP increased excitability, but did not elicit Ca2+ release from intracellular stores. Exposure to a Ca2+‐deficient solution did not deplete [Ca2+]i stores but did eliminate the PACAP‐induced increase in excitability. We postulate that Ca2+ influx is required for the PACAP‐induced increase in excitability.</description><identifier>ISSN: 0077-8923</identifier><identifier>EISSN: 1749-6632</identifier><identifier>DOI: 10.1196/annals.1317.036</identifier><identifier>PMID: 16888185</identifier><language>eng</language><publisher>Malden, USA: Blackwell Publishing Inc</publisher><subject>action potential generation ; Animals ; Calcium (intracellular) ; Calcium - metabolism ; calcium influx ; Cytosol - drug effects ; Cytosol - metabolism ; Guinea Pigs ; Heart - drug effects ; intracellular calcium release ; Ion Channel Gating ; Ion Channels - metabolism ; Myocardium - metabolism ; Neurons - drug effects ; Neurons - metabolism ; PACAP ; Pituitary Adenylate Cyclase-Activating Polypeptide - pharmacology ; voltage-dependent calcium channels</subject><ispartof>Annals of the New York Academy of Sciences, 2006-07, Vol.1070 (1), p.317-321</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4396-4aaba5059a4c244c52f2f77374c21349a41831f8525ce4862556638ebeff99d83</citedby><cites>FETCH-LOGICAL-c4396-4aaba5059a4c244c52f2f77374c21349a41831f8525ce4862556638ebeff99d83</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1196%2Fannals.1317.036$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1196%2Fannals.1317.036$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27903,27904,45553,45554</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16888185$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>HARDWICK, JEAN C.</creatorcontrib><creatorcontrib>TOMPKINS, JOHN D.</creatorcontrib><creatorcontrib>LOCKNAR, SARAH A.</creatorcontrib><creatorcontrib>MERRIAM, LAURA A.</creatorcontrib><creatorcontrib>YOUNG, BETH A.</creatorcontrib><creatorcontrib>PARSONS, RODNEY L.</creatorcontrib><title>Calcium Influx through Channels Other than Voltage-Dependent Calcium Channels Is Critical to the Pituitary Adenylate Cyclase-Activating Polypeptide-Induced Increase in Excitability in Guinea Pig Cardiac Neurons</title><title>Annals of the New York Academy of Sciences</title><addtitle>Ann N Y Acad Sci</addtitle><description>: Pituitary adenylate cyclase‐activating polypeptide (PACAP) effects on intracellular calcium ([Ca2+]i) and excitability have been studied in adult guinea pig intracardiac neurons. PACAP increased excitability, but did not elicit Ca2+ release from intracellular stores. Exposure to a Ca2+‐deficient solution did not deplete [Ca2+]i stores but did eliminate the PACAP‐induced increase in excitability. We postulate that Ca2+ influx is required for the PACAP‐induced increase in excitability.</description><subject>action potential generation</subject><subject>Animals</subject><subject>Calcium (intracellular)</subject><subject>Calcium - metabolism</subject><subject>calcium influx</subject><subject>Cytosol - drug effects</subject><subject>Cytosol - metabolism</subject><subject>Guinea Pigs</subject><subject>Heart - drug effects</subject><subject>intracellular calcium release</subject><subject>Ion Channel Gating</subject><subject>Ion Channels - metabolism</subject><subject>Myocardium - metabolism</subject><subject>Neurons - drug effects</subject><subject>Neurons - metabolism</subject><subject>PACAP</subject><subject>Pituitary Adenylate Cyclase-Activating Polypeptide - pharmacology</subject><subject>voltage-dependent calcium channels</subject><issn>0077-8923</issn><issn>1749-6632</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2006</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNksFv0zAUxiMEYmVw5oZ84pYujmPHOVbZKEVTN2kw4GS5zktrcJ3Mdljzb-4vwqVlHMfJek-_7_PTpy9J3uJsinHFzqS10vgpJricZoQ9Sya4LKqUMZI_TyZZVpYpr3Jykrzy_keW4ZwX5cvkBDPOOeZ0kjzU0ig9bNHCtmbYobBx3bDeoHoTrcF4dBU24OJaWnTbmSDXkJ5DD7YBG9Bf8SO98Kh2OmglDQpdlAG61mHQQboRzaJmNDIAqkdlpId0poL-JYO2a3TdmbGHPugG0oVtBgVNvEk5iBzSFl3sVHRZaaPDuJ_ng7Ygo_s6XuEaLRVawuA6618nL9oYCrw5vqfJlw8Xn-uP6eXVfFHPLlNVkIqlhZQrSTNayULlRaFo3uZtWZIyjpgUcY05wS2nOVVQcJZTGmPlsIK2raqGk9Pk_cG3d93dAD6IrfYKjJEWusELxktMWIGfBHFFWFXGr_8HpDTbg2cHULnOewet6J3exowFzsS-GOJQDLEvhojFiIp3R-thtYXmH39sQgTIAbjXBsan_MTy--zmj216UGkfYPeoku6nYDFKKr4u5-Lb-adbXmU3Ykl-AwLo2FA</recordid><startdate>200607</startdate><enddate>200607</enddate><creator>HARDWICK, JEAN C.</creator><creator>TOMPKINS, JOHN D.</creator><creator>LOCKNAR, SARAH A.</creator><creator>MERRIAM, LAURA A.</creator><creator>YOUNG, BETH A.</creator><creator>PARSONS, RODNEY L.</creator><general>Blackwell Publishing Inc</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>7TK</scope><scope>7X8</scope></search><sort><creationdate>200607</creationdate><title>Calcium Influx through Channels Other than Voltage-Dependent Calcium Channels Is Critical to the Pituitary Adenylate Cyclase-Activating Polypeptide-Induced Increase in Excitability in Guinea Pig Cardiac Neurons</title><author>HARDWICK, JEAN C. ; TOMPKINS, JOHN D. ; LOCKNAR, SARAH A. ; MERRIAM, LAURA A. ; YOUNG, BETH A. ; PARSONS, RODNEY L.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4396-4aaba5059a4c244c52f2f77374c21349a41831f8525ce4862556638ebeff99d83</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2006</creationdate><topic>action potential generation</topic><topic>Animals</topic><topic>Calcium (intracellular)</topic><topic>Calcium - metabolism</topic><topic>calcium influx</topic><topic>Cytosol - drug effects</topic><topic>Cytosol - metabolism</topic><topic>Guinea Pigs</topic><topic>Heart - drug effects</topic><topic>intracellular calcium release</topic><topic>Ion Channel Gating</topic><topic>Ion Channels - metabolism</topic><topic>Myocardium - metabolism</topic><topic>Neurons - drug effects</topic><topic>Neurons - metabolism</topic><topic>PACAP</topic><topic>Pituitary Adenylate Cyclase-Activating Polypeptide - pharmacology</topic><topic>voltage-dependent calcium channels</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>HARDWICK, JEAN C.</creatorcontrib><creatorcontrib>TOMPKINS, JOHN D.</creatorcontrib><creatorcontrib>LOCKNAR, SARAH A.</creatorcontrib><creatorcontrib>MERRIAM, LAURA A.</creatorcontrib><creatorcontrib>YOUNG, BETH A.</creatorcontrib><creatorcontrib>PARSONS, RODNEY L.</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Annals of the New York Academy of Sciences</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>HARDWICK, JEAN C.</au><au>TOMPKINS, JOHN D.</au><au>LOCKNAR, SARAH A.</au><au>MERRIAM, LAURA A.</au><au>YOUNG, BETH A.</au><au>PARSONS, RODNEY L.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Calcium Influx through Channels Other than Voltage-Dependent Calcium Channels Is Critical to the Pituitary Adenylate Cyclase-Activating Polypeptide-Induced Increase in Excitability in Guinea Pig Cardiac Neurons</atitle><jtitle>Annals of the New York Academy of Sciences</jtitle><addtitle>Ann N Y Acad Sci</addtitle><date>2006-07</date><risdate>2006</risdate><volume>1070</volume><issue>1</issue><spage>317</spage><epage>321</epage><pages>317-321</pages><issn>0077-8923</issn><eissn>1749-6632</eissn><abstract>: Pituitary adenylate cyclase‐activating polypeptide (PACAP) effects on intracellular calcium ([Ca2+]i) and excitability have been studied in adult guinea pig intracardiac neurons. PACAP increased excitability, but did not elicit Ca2+ release from intracellular stores. Exposure to a Ca2+‐deficient solution did not deplete [Ca2+]i stores but did eliminate the PACAP‐induced increase in excitability. We postulate that Ca2+ influx is required for the PACAP‐induced increase in excitability.</abstract><cop>Malden, USA</cop><pub>Blackwell Publishing Inc</pub><pmid>16888185</pmid><doi>10.1196/annals.1317.036</doi><tpages>5</tpages></addata></record> |
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| identifier | ISSN: 0077-8923 |
| ispartof | Annals of the New York Academy of Sciences, 2006-07, Vol.1070 (1), p.317-321 |
| issn | 0077-8923 1749-6632 |
| language | eng |
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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | action potential generation Animals Calcium (intracellular) Calcium - metabolism calcium influx Cytosol - drug effects Cytosol - metabolism Guinea Pigs Heart - drug effects intracellular calcium release Ion Channel Gating Ion Channels - metabolism Myocardium - metabolism Neurons - drug effects Neurons - metabolism PACAP Pituitary Adenylate Cyclase-Activating Polypeptide - pharmacology voltage-dependent calcium channels |
| title | Calcium Influx through Channels Other than Voltage-Dependent Calcium Channels Is Critical to the Pituitary Adenylate Cyclase-Activating Polypeptide-Induced Increase in Excitability in Guinea Pig Cardiac Neurons |
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