How ADAM-9 and ADAM-11 Differentially From Estrogen Receptor Predict Response to Tamoxifen Treatment in Patients with Recurrent Breast Cancer: a Retrospective Study

Purpose: To evaluate the predictive value of the disintegrin and metalloproteinases, ADAM-9, ADAM-10, ADAM-11, and ADAM-12, and of the matrix metalloproteinases, MMP-2 and MMP-9, in patients with recurrent breast cancer treated with tamoxifen. Experimental Design: A retrospective study was done on 2...

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Veröffentlicht in:	Clinical cancer research 2005-10, Vol.11 (20), p.7311-7321
Hauptverfasser:	SIEUWERTS, Anieta M, MEIJER-VAN GELDER, Marion E, TIMMERMANS, Mieke, TRAPMAN, Anita M. A. C, RODRIGUEZ GARCIA, Roberto, ARNOLD, Miranda, GOEDHEER, Anneke J. W, PORTENGEN, Henk, KLIJN, Jan G. M, FOEKENS, John A
Format:	Artikel
Sprache:	eng
Schlagworte:	ADAM ADAM Proteins - genetics ADAM Proteins - metabolism Adult Aged Aged, 80 and over Antineoplastic agents Antineoplastic Agents, Hormonal - therapeutic use Biological and medical sciences breast cancer Breast Neoplasms - drug therapy Breast Neoplasms - genetics Breast Neoplasms - metabolism Chemotherapy Female Gene Expression Profiling Gene Expression Regulation, Neoplastic Gynecology. Andrology. Obstetrics Humans Immunohistochemistry Mammary gland diseases Matrix Metalloproteinase 2 - genetics Matrix Metalloproteinase 2 - metabolism Matrix Metalloproteinase 9 - genetics Matrix Metalloproteinase 9 - metabolism Medical sciences Middle Aged Multivariate Analysis Neoplasm Recurrence, Local Pharmacology. Drug treatments Predictive Value of Tests Prognosis real-time PCR Receptors, Estrogen - genetics Receptors, Estrogen - metabolism Receptors, Progesterone - genetics Receptors, Progesterone - metabolism response prediction Retrospective Studies Reverse Transcriptase Polymerase Chain Reaction RNA, Messenger - genetics RNA, Messenger - metabolism Survival Analysis tamoxifen Tamoxifen - therapeutic use Tumors
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