Host immunity modulates transcriptional changes in a multigene family (yir) of rodent malaria
Summary Variant antigens, encoded by multigene families, and expressed at the surface of erythrocytes infected with the human malaria parasite Plasmodium falciparum and the simian parasite Plasmodium knowlesi, are important in evasion of host immunity. The vir multigene family, encoding a very large...
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| Veröffentlicht in: | Molecular microbiology 2005-11, Vol.58 (3), p.636-647 |
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| creator | Cunningham, Deirdre A. Jarra, William Koernig, Sandra Fonager, Jannik Fernandez‐Reyes, Delmiro Blythe, Jane E. Waller, Cecilia Preiser, Peter R. Langhorne, Jean |
| description | Summary
Variant antigens, encoded by multigene families, and expressed at the surface of erythrocytes infected with the human malaria parasite Plasmodium falciparum and the simian parasite Plasmodium knowlesi, are important in evasion of host immunity. The vir multigene family, encoding a very large number of variant antigens, has been identified in the human parasite Plasmodium vivax and homologues (yir) of this family exist in the rodent parasite Plasmodium yoelii. These genes are part of a superfamily (pir) which are found in Plasmodium species infecting rodents, monkeys and humans (P. yoelii, P. berghei, P. chabaudi, P. knowlesi and P. vivax). Here, we show that YIR proteins are expressed on the surface of erythrocytes infected with late‐stage asexual parasites, and that host immunity modulates transcription of yir genes. The surface location and expression pattern of YIR is consistent with a role in antigenic variation. This provides a unique opportunity to study the regulation and expression of the pir superfamily, and its role in both protective immunity and antigenic variation, in an easily accessible animal model system. |
| doi_str_mv | 10.1111/j.1365-2958.2005.04840.x |
| format | Article |
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Variant antigens, encoded by multigene families, and expressed at the surface of erythrocytes infected with the human malaria parasite Plasmodium falciparum and the simian parasite Plasmodium knowlesi, are important in evasion of host immunity. The vir multigene family, encoding a very large number of variant antigens, has been identified in the human parasite Plasmodium vivax and homologues (yir) of this family exist in the rodent parasite Plasmodium yoelii. These genes are part of a superfamily (pir) which are found in Plasmodium species infecting rodents, monkeys and humans (P. yoelii, P. berghei, P. chabaudi, P. knowlesi and P. vivax). Here, we show that YIR proteins are expressed on the surface of erythrocytes infected with late‐stage asexual parasites, and that host immunity modulates transcription of yir genes. The surface location and expression pattern of YIR is consistent with a role in antigenic variation. This provides a unique opportunity to study the regulation and expression of the pir superfamily, and its role in both protective immunity and antigenic variation, in an easily accessible animal model system.</description><identifier>ISSN: 0950-382X</identifier><identifier>EISSN: 1365-2958</identifier><identifier>DOI: 10.1111/j.1365-2958.2005.04840.x</identifier><identifier>PMID: 16238615</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Science Ltd</publisher><subject>Animals ; Antigenic Variation ; Antigens ; Antigens, Protozoan - classification ; Antigens, Protozoan - genetics ; Antigens, Protozoan - immunology ; Biological and medical sciences ; Disease Models, Animal ; Erythrocytes ; Erythrocytes - cytology ; Erythrocytes - metabolism ; Erythrocytes - microbiology ; Female ; Fundamental and applied biological sciences. Psychology ; Gene expression ; Gene Expression Regulation ; Host-Parasite Interactions ; Human protozoal diseases ; Humans ; Immune System - physiology ; Infectious diseases ; Malaria ; Malaria - immunology ; Malaria - microbiology ; Male ; Medical sciences ; Mice ; Mice, Inbred BALB C ; Microbiology ; Multigene Family ; Parasites ; Parasitic diseases ; Phylogeny ; Plasmodium - genetics ; Plasmodium - immunology ; Polymorphism, Restriction Fragment Length ; Protozoal diseases ; Protozoan Proteins - classification ; Protozoan Proteins - genetics ; Protozoan Proteins - immunology ; Rodents ; Transcription, Genetic</subject><ispartof>Molecular microbiology, 2005-11, Vol.58 (3), p.636-647</ispartof><rights>2005 INIST-CNRS</rights><rights>Copyright Blackwell Publishing Nov 2005</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5400-f58e11c8a7571cfc813a16d33389fddf98b4e6019bf36ccff4527b5d9b8b6b553</citedby><cites>FETCH-LOGICAL-c5400-f58e11c8a7571cfc813a16d33389fddf98b4e6019bf36ccff4527b5d9b8b6b553</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fj.1365-2958.2005.04840.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fj.1365-2958.2005.04840.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,1427,27901,27902,45550,45551,46384,46808</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=17193299$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16238615$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Cunningham, Deirdre A.</creatorcontrib><creatorcontrib>Jarra, William</creatorcontrib><creatorcontrib>Koernig, Sandra</creatorcontrib><creatorcontrib>Fonager, Jannik</creatorcontrib><creatorcontrib>Fernandez‐Reyes, Delmiro</creatorcontrib><creatorcontrib>Blythe, Jane E.</creatorcontrib><creatorcontrib>Waller, Cecilia</creatorcontrib><creatorcontrib>Preiser, Peter R.</creatorcontrib><creatorcontrib>Langhorne, Jean</creatorcontrib><title>Host immunity modulates transcriptional changes in a multigene family (yir) of rodent malaria</title><title>Molecular microbiology</title><addtitle>Mol Microbiol</addtitle><description>Summary
Variant antigens, encoded by multigene families, and expressed at the surface of erythrocytes infected with the human malaria parasite Plasmodium falciparum and the simian parasite Plasmodium knowlesi, are important in evasion of host immunity. The vir multigene family, encoding a very large number of variant antigens, has been identified in the human parasite Plasmodium vivax and homologues (yir) of this family exist in the rodent parasite Plasmodium yoelii. These genes are part of a superfamily (pir) which are found in Plasmodium species infecting rodents, monkeys and humans (P. yoelii, P. berghei, P. chabaudi, P. knowlesi and P. vivax). Here, we show that YIR proteins are expressed on the surface of erythrocytes infected with late‐stage asexual parasites, and that host immunity modulates transcription of yir genes. The surface location and expression pattern of YIR is consistent with a role in antigenic variation. This provides a unique opportunity to study the regulation and expression of the pir superfamily, and its role in both protective immunity and antigenic variation, in an easily accessible animal model system.</description><subject>Animals</subject><subject>Antigenic Variation</subject><subject>Antigens</subject><subject>Antigens, Protozoan - classification</subject><subject>Antigens, Protozoan - genetics</subject><subject>Antigens, Protozoan - immunology</subject><subject>Biological and medical sciences</subject><subject>Disease Models, Animal</subject><subject>Erythrocytes</subject><subject>Erythrocytes - cytology</subject><subject>Erythrocytes - metabolism</subject><subject>Erythrocytes - microbiology</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Gene expression</subject><subject>Gene Expression Regulation</subject><subject>Host-Parasite Interactions</subject><subject>Human protozoal diseases</subject><subject>Humans</subject><subject>Immune System - physiology</subject><subject>Infectious diseases</subject><subject>Malaria</subject><subject>Malaria - immunology</subject><subject>Malaria - microbiology</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Mice</subject><subject>Mice, Inbred BALB C</subject><subject>Microbiology</subject><subject>Multigene Family</subject><subject>Parasites</subject><subject>Parasitic diseases</subject><subject>Phylogeny</subject><subject>Plasmodium - genetics</subject><subject>Plasmodium - immunology</subject><subject>Polymorphism, Restriction Fragment Length</subject><subject>Protozoal diseases</subject><subject>Protozoan Proteins - classification</subject><subject>Protozoan Proteins - genetics</subject><subject>Protozoan Proteins - immunology</subject><subject>Rodents</subject><subject>Transcription, Genetic</subject><issn>0950-382X</issn><issn>1365-2958</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkMFuFSEUhkmjaa_VV2hIE40uZgrDwMDChWnUNmnjpiZuDGEYaLmB4RZmYuftZbw3NnElm0M43_nD-QCAGNW4nIttjQmjVSMorxuEaI1a3qL66Qhs_jZegA0SFFWENz9OwKuctwhhghg5BieYNYQzTDfg51XME3QhzKObFhjiMHs1mQynpMask9tNLo7KQ_2gxvvy7kaoYJj95O7NaKBVwfkFvl9c-gCjhSkOZpxgUF4lp16Dl1b5bN4c6in4_uXz3eVVdfPt6_Xlp5tK0xahylJuMNZcdbTD2mqOicJsIIRwYYfBCt63hiEsekuY1ta2tOl6Ooie96ynlJyCd_vcXYqPs8mTDC5r470aTZyzZLzDZeMVPP8H3MY5lf2yxIKVVNryAvE9pFPMORkrd8kFlRaJkVz9y61cNctVs1z9yz_-5VMZPTvkz30ww_PgQXgB3h4AlbXytljWLj9zHRakEaJwH_fcL-fN8t8fkLe31-uN_AZaLaE6</recordid><startdate>200511</startdate><enddate>200511</enddate><creator>Cunningham, Deirdre A.</creator><creator>Jarra, William</creator><creator>Koernig, Sandra</creator><creator>Fonager, Jannik</creator><creator>Fernandez‐Reyes, Delmiro</creator><creator>Blythe, Jane E.</creator><creator>Waller, Cecilia</creator><creator>Preiser, Peter R.</creator><creator>Langhorne, Jean</creator><general>Blackwell Science Ltd</general><general>Blackwell Science</general><general>Blackwell Publishing Ltd</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QL</scope><scope>7QP</scope><scope>7QR</scope><scope>7TK</scope><scope>7TM</scope><scope>7U9</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>H94</scope><scope>M7N</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope></search><sort><creationdate>200511</creationdate><title>Host immunity modulates transcriptional changes in a multigene family (yir) of rodent malaria</title><author>Cunningham, Deirdre A. ; Jarra, William ; Koernig, Sandra ; Fonager, Jannik ; Fernandez‐Reyes, Delmiro ; Blythe, Jane E. ; Waller, Cecilia ; Preiser, Peter R. ; Langhorne, Jean</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5400-f58e11c8a7571cfc813a16d33389fddf98b4e6019bf36ccff4527b5d9b8b6b553</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>Animals</topic><topic>Antigenic Variation</topic><topic>Antigens</topic><topic>Antigens, Protozoan - classification</topic><topic>Antigens, Protozoan - genetics</topic><topic>Antigens, Protozoan - immunology</topic><topic>Biological and medical sciences</topic><topic>Disease Models, Animal</topic><topic>Erythrocytes</topic><topic>Erythrocytes - cytology</topic><topic>Erythrocytes - metabolism</topic><topic>Erythrocytes - microbiology</topic><topic>Female</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Gene expression</topic><topic>Gene Expression Regulation</topic><topic>Host-Parasite Interactions</topic><topic>Human protozoal diseases</topic><topic>Humans</topic><topic>Immune System - physiology</topic><topic>Infectious diseases</topic><topic>Malaria</topic><topic>Malaria - immunology</topic><topic>Malaria - microbiology</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Mice</topic><topic>Mice, Inbred BALB C</topic><topic>Microbiology</topic><topic>Multigene Family</topic><topic>Parasites</topic><topic>Parasitic diseases</topic><topic>Phylogeny</topic><topic>Plasmodium - genetics</topic><topic>Plasmodium - immunology</topic><topic>Polymorphism, Restriction Fragment Length</topic><topic>Protozoal diseases</topic><topic>Protozoan Proteins - classification</topic><topic>Protozoan Proteins - genetics</topic><topic>Protozoan Proteins - immunology</topic><topic>Rodents</topic><topic>Transcription, Genetic</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Cunningham, Deirdre A.</creatorcontrib><creatorcontrib>Jarra, William</creatorcontrib><creatorcontrib>Koernig, Sandra</creatorcontrib><creatorcontrib>Fonager, Jannik</creatorcontrib><creatorcontrib>Fernandez‐Reyes, Delmiro</creatorcontrib><creatorcontrib>Blythe, Jane E.</creatorcontrib><creatorcontrib>Waller, Cecilia</creatorcontrib><creatorcontrib>Preiser, Peter R.</creatorcontrib><creatorcontrib>Langhorne, Jean</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Molecular microbiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Cunningham, Deirdre A.</au><au>Jarra, William</au><au>Koernig, Sandra</au><au>Fonager, Jannik</au><au>Fernandez‐Reyes, Delmiro</au><au>Blythe, Jane E.</au><au>Waller, Cecilia</au><au>Preiser, Peter R.</au><au>Langhorne, Jean</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Host immunity modulates transcriptional changes in a multigene family (yir) of rodent malaria</atitle><jtitle>Molecular microbiology</jtitle><addtitle>Mol Microbiol</addtitle><date>2005-11</date><risdate>2005</risdate><volume>58</volume><issue>3</issue><spage>636</spage><epage>647</epage><pages>636-647</pages><issn>0950-382X</issn><eissn>1365-2958</eissn><abstract>Summary
Variant antigens, encoded by multigene families, and expressed at the surface of erythrocytes infected with the human malaria parasite Plasmodium falciparum and the simian parasite Plasmodium knowlesi, are important in evasion of host immunity. The vir multigene family, encoding a very large number of variant antigens, has been identified in the human parasite Plasmodium vivax and homologues (yir) of this family exist in the rodent parasite Plasmodium yoelii. These genes are part of a superfamily (pir) which are found in Plasmodium species infecting rodents, monkeys and humans (P. yoelii, P. berghei, P. chabaudi, P. knowlesi and P. vivax). Here, we show that YIR proteins are expressed on the surface of erythrocytes infected with late‐stage asexual parasites, and that host immunity modulates transcription of yir genes. The surface location and expression pattern of YIR is consistent with a role in antigenic variation. This provides a unique opportunity to study the regulation and expression of the pir superfamily, and its role in both protective immunity and antigenic variation, in an easily accessible animal model system.</abstract><cop>Oxford, UK</cop><pub>Blackwell Science Ltd</pub><pmid>16238615</pmid><doi>10.1111/j.1365-2958.2005.04840.x</doi><tpages>12</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Animals Antigenic Variation Antigens Antigens, Protozoan - classification Antigens, Protozoan - genetics Antigens, Protozoan - immunology Biological and medical sciences Disease Models, Animal Erythrocytes Erythrocytes - cytology Erythrocytes - metabolism Erythrocytes - microbiology Female Fundamental and applied biological sciences. Psychology Gene expression Gene Expression Regulation Host-Parasite Interactions Human protozoal diseases Humans Immune System - physiology Infectious diseases Malaria Malaria - immunology Malaria - microbiology Male Medical sciences Mice Mice, Inbred BALB C Microbiology Multigene Family Parasites Parasitic diseases Phylogeny Plasmodium - genetics Plasmodium - immunology Polymorphism, Restriction Fragment Length Protozoal diseases Protozoan Proteins - classification Protozoan Proteins - genetics Protozoan Proteins - immunology Rodents Transcription, Genetic |
| title | Host immunity modulates transcriptional changes in a multigene family (yir) of rodent malaria |
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