DNase II is a member of the phospholipase D superfamily
Motivation: DNase II is an endodeoxyribonuclease involved in apoptosis and essential for the mammalian development. Despite the understanding of biochemical properties of this enzyme, its structure and relationships to other protein families remain unknown. Results: Using protein fold-recognition we...
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| Veröffentlicht in: | Bioinformatics 2005-11, Vol.21 (21), p.3959-3962 |
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| container_title | Bioinformatics |
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| creator | Cymerman, Iwona A. Meiss, Gregor Bujnicki, Janusz M. |
| description | Motivation: DNase II is an endodeoxyribonuclease involved in apoptosis and essential for the mammalian development. Despite the understanding of biochemical properties of this enzyme, its structure and relationships to other protein families remain unknown. Results: Using protein fold-recognition we found that DNase II exhibits a catalytic domain common to the phospholipase D superfamily. Our model explains the available experimental data and provides the first structural platform for sequence–function analyses of this important nuclease. Contact: iamb@genesilico.pl Supplementary information: ftp://genesilico.pl/iamb/models/DNasell/ |
| doi_str_mv | 10.1093/bioinformatics/bti659 |
| format | Article |
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Despite the understanding of biochemical properties of this enzyme, its structure and relationships to other protein families remain unknown. Results: Using protein fold-recognition we found that DNase II exhibits a catalytic domain common to the phospholipase D superfamily. Our model explains the available experimental data and provides the first structural platform for sequence–function analyses of this important nuclease. 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| source | MEDLINE; EZB Free E-Journals; Alma/SFX Local Collection; Oxford Academic Journals (Open Access) |
| subjects | Amino Acid Sequence Biological and medical sciences Computer Simulation Endodeoxyribonucleases - analysis Endodeoxyribonucleases - chemistry Endodeoxyribonucleases - classification Fundamental and applied biological sciences. Psychology General aspects Mathematics in biology. Statistical analysis. Models. Metrology. Data processing in biology (general aspects) Models, Chemical Models, Molecular Molecular Sequence Data Phospholipase D - analysis Phospholipase D - chemistry Phospholipase D - classification Protein Conformation Sequence Alignment - methods Sequence Analysis, Protein - methods Sequence Homology, Amino Acid Structure-Activity Relationship |
| title | DNase II is a member of the phospholipase D superfamily |
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