Clinical correlates of DHEA associated with post-traumatic stress disorder
Objective: Increased plasma dehydroepiandrosterone (DHEA) and dehydroepiandrosterone‐sulfate (DHEAS) have been demonstrated in post‐traumatic stress disorder (PTSD), but the documented beneficial effects of these steroids in enhancing mood and cognition, as well as neuroprotection, suggest their pr...
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| Veröffentlicht in: | Acta psychiatrica Scandinavica 2006-09, Vol.114 (3), p.187-193 |
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| container_title | Acta psychiatrica Scandinavica |
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| creator | Yehuda, R. Brand, S. R. Golier, J. A. Yang, R.-K. |
| description | Objective: Increased plasma dehydroepiandrosterone (DHEA) and dehydroepiandrosterone‐sulfate (DHEAS) have been demonstrated in post‐traumatic stress disorder (PTSD), but the documented beneficial effects of these steroids in enhancing mood and cognition, as well as neuroprotection, suggest their presence in PTSD may be associated with defensive rather than maladaptive effects.
Method: We, therefore, examined plasma DHEA, DHEAS, cortisol, and the DHEA/cortisol ratio in 40 male veterans with or without PTSD, and determined their relationships to PTSD symptom severity and symptom improvement.
Results: The PTSD group showed significantly higher plasma DHEA and non‐significantly higher DHEAS levels as well as a significantly lower cortisol/DHEA ratio, controlling for age. Regression analyses demonstrated that DHEA and DHEAS levels could be predicted by symptom improvement and coping, whereas the cortisol/DHEA ratio was predicted by severity of childhood trauma and current symptom severity.
Conclusion: That greater symptom improvement was related to DHEA levels may suggest for a role for these hormones in modulating recovery from PTSD. |
| doi_str_mv | 10.1111/j.1600-0447.2006.00801.x |
| format | Article |
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Method: We, therefore, examined plasma DHEA, DHEAS, cortisol, and the DHEA/cortisol ratio in 40 male veterans with or without PTSD, and determined their relationships to PTSD symptom severity and symptom improvement.
Results: The PTSD group showed significantly higher plasma DHEA and non‐significantly higher DHEAS levels as well as a significantly lower cortisol/DHEA ratio, controlling for age. Regression analyses demonstrated that DHEA and DHEAS levels could be predicted by symptom improvement and coping, whereas the cortisol/DHEA ratio was predicted by severity of childhood trauma and current symptom severity.
Conclusion: That greater symptom improvement was related to DHEA levels may suggest for a role for these hormones in modulating recovery from PTSD.</description><identifier>ISSN: 0001-690X</identifier><identifier>EISSN: 1600-0447</identifier><identifier>DOI: 10.1111/j.1600-0447.2006.00801.x</identifier><identifier>PMID: 16889589</identifier><identifier>CODEN: APYSA9</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Publishing Ltd</publisher><subject>Adaptation, Psychological - physiology ; Adult and adolescent clinical studies ; Aged ; Aged, 80 and over ; Anxiety disorders. Neuroses ; Arousal - physiology ; Biological and medical sciences ; Combat Disorders - blood ; Combat Disorders - diagnosis ; Combat Disorders - psychology ; Defense Mechanisms ; Dehydroepiandrosterone - blood ; Dehydroepiandrosterone Sulfate - blood ; dehydroepiandrosterone-sulfate ; Follow-Up Studies ; glucocorticoids ; Humans ; Hydrocortisone - blood ; Life Change Events ; Male ; Medical research ; Medical sciences ; Middle Aged ; New York City ; plasma dehydroepiandrosterone ; Post traumatic stress disorder ; Psychiatry ; Psychology. Psychoanalysis. Psychiatry ; Psychopathology. Psychiatry ; Risk Factors ; Steroids ; Stress Disorders, Post-Traumatic - blood ; Stress Disorders, Post-Traumatic - diagnosis ; Stress Disorders, Post-Traumatic - psychology ; Veterans - psychology</subject><ispartof>Acta psychiatrica Scandinavica, 2006-09, Vol.114 (3), p.187-193</ispartof><rights>2006 INIST-CNRS</rights><rights>2006 Blackwell Munksgaard No claim to original US government works</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5261-2864a34caf6c7cbd3858fd3a4cbb86c9364b1e6f7bbd6e1a88727ca8419ae3143</citedby><cites>FETCH-LOGICAL-c5261-2864a34caf6c7cbd3858fd3a4cbb86c9364b1e6f7bbd6e1a88727ca8419ae3143</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fj.1600-0447.2006.00801.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fj.1600-0447.2006.00801.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=18079382$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16889589$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Yehuda, R.</creatorcontrib><creatorcontrib>Brand, S. R.</creatorcontrib><creatorcontrib>Golier, J. A.</creatorcontrib><creatorcontrib>Yang, R.-K.</creatorcontrib><title>Clinical correlates of DHEA associated with post-traumatic stress disorder</title><title>Acta psychiatrica Scandinavica</title><addtitle>Acta Psychiatr Scand</addtitle><description>Objective: Increased plasma dehydroepiandrosterone (DHEA) and dehydroepiandrosterone‐sulfate (DHEAS) have been demonstrated in post‐traumatic stress disorder (PTSD), but the documented beneficial effects of these steroids in enhancing mood and cognition, as well as neuroprotection, suggest their presence in PTSD may be associated with defensive rather than maladaptive effects.
Method: We, therefore, examined plasma DHEA, DHEAS, cortisol, and the DHEA/cortisol ratio in 40 male veterans with or without PTSD, and determined their relationships to PTSD symptom severity and symptom improvement.
Results: The PTSD group showed significantly higher plasma DHEA and non‐significantly higher DHEAS levels as well as a significantly lower cortisol/DHEA ratio, controlling for age. Regression analyses demonstrated that DHEA and DHEAS levels could be predicted by symptom improvement and coping, whereas the cortisol/DHEA ratio was predicted by severity of childhood trauma and current symptom severity.
Conclusion: That greater symptom improvement was related to DHEA levels may suggest for a role for these hormones in modulating recovery from PTSD.</description><subject>Adaptation, Psychological - physiology</subject><subject>Adult and adolescent clinical studies</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Anxiety disorders. Neuroses</subject><subject>Arousal - physiology</subject><subject>Biological and medical sciences</subject><subject>Combat Disorders - blood</subject><subject>Combat Disorders - diagnosis</subject><subject>Combat Disorders - psychology</subject><subject>Defense Mechanisms</subject><subject>Dehydroepiandrosterone - blood</subject><subject>Dehydroepiandrosterone Sulfate - blood</subject><subject>dehydroepiandrosterone-sulfate</subject><subject>Follow-Up Studies</subject><subject>glucocorticoids</subject><subject>Humans</subject><subject>Hydrocortisone - blood</subject><subject>Life Change Events</subject><subject>Male</subject><subject>Medical research</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>New York City</subject><subject>plasma dehydroepiandrosterone</subject><subject>Post traumatic stress disorder</subject><subject>Psychiatry</subject><subject>Psychology. Psychoanalysis. Psychiatry</subject><subject>Psychopathology. Psychiatry</subject><subject>Risk Factors</subject><subject>Steroids</subject><subject>Stress Disorders, Post-Traumatic - blood</subject><subject>Stress Disorders, Post-Traumatic - diagnosis</subject><subject>Stress Disorders, Post-Traumatic - psychology</subject><subject>Veterans - psychology</subject><issn>0001-690X</issn><issn>1600-0447</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2006</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkU1v1DAQhi0EokvhL6AICW4J49jxx4HDNpQuUAESIBAXy3Ec4SW7WTyJuv33ON1VK3GBuVgzft7RzLyEZBQKmuLluqACIAfOZVECiAJAAS3298ji9uM-WQAAzYWG7yfkEeI6pRUF9ZCcUKGUrpRekHd1H7bB2T5zQ4y-t6PHbOiy16vzZWYRBxdSqc2uwvgz2w045mO008aOwWU4Ro-YtQGH2Pr4mDzobI_-yfE9JV_fnH-pV_nlx4u39fIyd1UpaF4qwS3jznbCSde0TFWqa5nlrmmUcJoJ3lAvOtk0rfDUKiVL6aziVFvPKGen5MWh7y4OvyePo9kEdL7v7dYPExqhJKVMy3-CVDMNDGgCn_0FrocpbtMSiakU1wBlgtQBcnFAjL4zuxg2Nl4bCmZ2xazNfHwzH9_MrpgbV8w-SZ8e-0_Nxrd3wqMNCXh-BCwmL7poty7gHadAaqbmGV4duKvQ--v_HsAs60-f1c2i-UEfcPT7W72Nv4yQTFbm24cLs6rP3mtWrcwP9gdnubY3</recordid><startdate>200609</startdate><enddate>200609</enddate><creator>Yehuda, R.</creator><creator>Brand, S. R.</creator><creator>Golier, J. A.</creator><creator>Yang, R.-K.</creator><general>Blackwell Publishing Ltd</general><general>Blackwell</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>K9.</scope><scope>7X8</scope></search><sort><creationdate>200609</creationdate><title>Clinical correlates of DHEA associated with post-traumatic stress disorder</title><author>Yehuda, R. ; Brand, S. R. ; Golier, J. A. ; Yang, R.-K.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5261-2864a34caf6c7cbd3858fd3a4cbb86c9364b1e6f7bbd6e1a88727ca8419ae3143</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2006</creationdate><topic>Adaptation, Psychological - physiology</topic><topic>Adult and adolescent clinical studies</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Anxiety disorders. Neuroses</topic><topic>Arousal - physiology</topic><topic>Biological and medical sciences</topic><topic>Combat Disorders - blood</topic><topic>Combat Disorders - diagnosis</topic><topic>Combat Disorders - psychology</topic><topic>Defense Mechanisms</topic><topic>Dehydroepiandrosterone - blood</topic><topic>Dehydroepiandrosterone Sulfate - blood</topic><topic>dehydroepiandrosterone-sulfate</topic><topic>Follow-Up Studies</topic><topic>glucocorticoids</topic><topic>Humans</topic><topic>Hydrocortisone - blood</topic><topic>Life Change Events</topic><topic>Male</topic><topic>Medical research</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>New York City</topic><topic>plasma dehydroepiandrosterone</topic><topic>Post traumatic stress disorder</topic><topic>Psychiatry</topic><topic>Psychology. Psychoanalysis. Psychiatry</topic><topic>Psychopathology. Psychiatry</topic><topic>Risk Factors</topic><topic>Steroids</topic><topic>Stress Disorders, Post-Traumatic - blood</topic><topic>Stress Disorders, Post-Traumatic - diagnosis</topic><topic>Stress Disorders, Post-Traumatic - psychology</topic><topic>Veterans - psychology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Yehuda, R.</creatorcontrib><creatorcontrib>Brand, S. R.</creatorcontrib><creatorcontrib>Golier, J. A.</creatorcontrib><creatorcontrib>Yang, R.-K.</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>Acta psychiatrica Scandinavica</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Yehuda, R.</au><au>Brand, S. R.</au><au>Golier, J. A.</au><au>Yang, R.-K.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Clinical correlates of DHEA associated with post-traumatic stress disorder</atitle><jtitle>Acta psychiatrica Scandinavica</jtitle><addtitle>Acta Psychiatr Scand</addtitle><date>2006-09</date><risdate>2006</risdate><volume>114</volume><issue>3</issue><spage>187</spage><epage>193</epage><pages>187-193</pages><issn>0001-690X</issn><eissn>1600-0447</eissn><coden>APYSA9</coden><abstract>Objective: Increased plasma dehydroepiandrosterone (DHEA) and dehydroepiandrosterone‐sulfate (DHEAS) have been demonstrated in post‐traumatic stress disorder (PTSD), but the documented beneficial effects of these steroids in enhancing mood and cognition, as well as neuroprotection, suggest their presence in PTSD may be associated with defensive rather than maladaptive effects.
Method: We, therefore, examined plasma DHEA, DHEAS, cortisol, and the DHEA/cortisol ratio in 40 male veterans with or without PTSD, and determined their relationships to PTSD symptom severity and symptom improvement.
Results: The PTSD group showed significantly higher plasma DHEA and non‐significantly higher DHEAS levels as well as a significantly lower cortisol/DHEA ratio, controlling for age. Regression analyses demonstrated that DHEA and DHEAS levels could be predicted by symptom improvement and coping, whereas the cortisol/DHEA ratio was predicted by severity of childhood trauma and current symptom severity.
Conclusion: That greater symptom improvement was related to DHEA levels may suggest for a role for these hormones in modulating recovery from PTSD.</abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><pmid>16889589</pmid><doi>10.1111/j.1600-0447.2006.00801.x</doi><tpages>7</tpages></addata></record> |
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| subjects | Adaptation, Psychological - physiology Adult and adolescent clinical studies Aged Aged, 80 and over Anxiety disorders. Neuroses Arousal - physiology Biological and medical sciences Combat Disorders - blood Combat Disorders - diagnosis Combat Disorders - psychology Defense Mechanisms Dehydroepiandrosterone - blood Dehydroepiandrosterone Sulfate - blood dehydroepiandrosterone-sulfate Follow-Up Studies glucocorticoids Humans Hydrocortisone - blood Life Change Events Male Medical research Medical sciences Middle Aged New York City plasma dehydroepiandrosterone Post traumatic stress disorder Psychiatry Psychology. Psychoanalysis. Psychiatry Psychopathology. Psychiatry Risk Factors Steroids Stress Disorders, Post-Traumatic - blood Stress Disorders, Post-Traumatic - diagnosis Stress Disorders, Post-Traumatic - psychology Veterans - psychology |
| title | Clinical correlates of DHEA associated with post-traumatic stress disorder |
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