Different effect of statins on platelet oxidized-LDL receptor (CD36 and LOX-1) expression in hypercholesterolemic subjects

Hydroxymethyl-glutaryl-CoA-reductase inhibitors (statins) reduce cardiovascular mortality by decreasing cholesterol as well as by non-lipid-related actions. Oxidized low-density lipoproteins (ox-LDL) are pro-atherogenic molecules and potent platelet agonists. CD36 and lectin-like ox-LDL receptor-1 (...

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Veröffentlicht in:	Clinical and applied thrombosis/hemostasis 2005-10, Vol.11 (4), p.417-428
Hauptverfasser:	Bruni, Fulvio, Pasqui, Anna Laura, Pastorelli, Marcello, Bova, Giovanni, Cercignani, Michela, Palazzuoli, Alberto, Sawamura, Tatsuya, Gioffre, W R, Auteri, Alberto, Puccetti, Luca
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Blood Platelets - drug effects Blood Platelets - metabolism CD36 Antigens - metabolism Female Gene Expression Regulation - drug effects Humans Hydroxymethylglutaryl-CoA Reductase Inhibitors - pharmacology Hypercholesterolemia - metabolism Male Middle Aged P-Selectin - metabolism Platelet Activation - drug effects Scavenger Receptors, Class E - metabolism Thrombin - pharmacology
Online-Zugang:	Volltext
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