Production of D-arabitol by a metabolic engineered strain of Bacillus subtilis
A novel method for D‐arabitol production with a metabolically engineered Bacillus subtilis strain is described. A known transketolase‐deficient and D‐ribose‐producing mutant of B. subtilis (ATCC 31094) was further modified by disruption of its rpi (D‐ribose phosphate isomerase) gene to create a D‐ri...
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| Veröffentlicht in: | Biotechnology journal 2006-02, Vol.1 (2), p.214-219 |
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| creator | Povelainen, Mira Miasnikov, Andrei N. |
| description | A novel method for D‐arabitol production with a metabolically engineered Bacillus subtilis strain is described. A known transketolase‐deficient and D‐ribose‐producing mutant of B. subtilis (ATCC 31094) was further modified by disruption of its rpi (D‐ribose phosphate isomerase) gene to create a D‐ribulose‐ and D‐xylulose‐producing B. subtilis strain. Expression of the D‐arabitol phosphate dehydrogenase gene of Enterococcus avium in the D‐ribulose‐ and D‐xylulose‐producing strain resulted in a strain of B. subtilis capable of converting D‐glucose to D‐arabitol with a high yield (38%) and little by‐product formation. |
| doi_str_mv | 10.1002/biot.200500035 |
| format | Article |
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A known transketolase‐deficient and D‐ribose‐producing mutant of B. subtilis (ATCC 31094) was further modified by disruption of its rpi (D‐ribose phosphate isomerase) gene to create a D‐ribulose‐ and D‐xylulose‐producing B. subtilis strain. Expression of the D‐arabitol phosphate dehydrogenase gene of Enterococcus avium in the D‐ribulose‐ and D‐xylulose‐producing strain resulted in a strain of B. subtilis capable of converting D‐glucose to D‐arabitol with a high yield (38%) and little by‐product formation.</description><identifier>ISSN: 1860-6768</identifier><identifier>EISSN: 1860-7314</identifier><identifier>DOI: 10.1002/biot.200500035</identifier><identifier>PMID: 16892251</identifier><language>eng</language><publisher>Weinheim: WILEY-VCH Verlag</publisher><subject>Bacillus subtilis ; Bacillus subtilis - genetics ; Bacillus subtilis - metabolism ; D-Arabitol ; D-Arabitol phosphate dehydrogenase ; Enterococcus - enzymology ; Enterococcus - genetics ; Enterococcus avium ; Genetic Enhancement - methods ; Glucose - metabolism ; Polyhydroxy alcohol ; Protein Engineering - methods ; Sugar Alcohol Dehydrogenases - genetics ; Sugar Alcohol Dehydrogenases - metabolism ; Sugar Alcohols - isolation & purification ; Sugar Alcohols - metabolism</subject><ispartof>Biotechnology journal, 2006-02, Vol.1 (2), p.214-219</ispartof><rights>Copyright © 2006 WILEY‐VCH Verlag GmbH & Co. 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A known transketolase‐deficient and D‐ribose‐producing mutant of B. subtilis (ATCC 31094) was further modified by disruption of its rpi (D‐ribose phosphate isomerase) gene to create a D‐ribulose‐ and D‐xylulose‐producing B. subtilis strain. Expression of the D‐arabitol phosphate dehydrogenase gene of Enterococcus avium in the D‐ribulose‐ and D‐xylulose‐producing strain resulted in a strain of B. subtilis capable of converting D‐glucose to D‐arabitol with a high yield (38%) and little by‐product formation.</description><subject>Bacillus subtilis</subject><subject>Bacillus subtilis - genetics</subject><subject>Bacillus subtilis - metabolism</subject><subject>D-Arabitol</subject><subject>D-Arabitol phosphate dehydrogenase</subject><subject>Enterococcus - enzymology</subject><subject>Enterococcus - genetics</subject><subject>Enterococcus avium</subject><subject>Genetic Enhancement - methods</subject><subject>Glucose - metabolism</subject><subject>Polyhydroxy alcohol</subject><subject>Protein Engineering - methods</subject><subject>Sugar Alcohol Dehydrogenases - genetics</subject><subject>Sugar Alcohol Dehydrogenases - metabolism</subject><subject>Sugar Alcohols - isolation & purification</subject><subject>Sugar Alcohols - metabolism</subject><issn>1860-6768</issn><issn>1860-7314</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2006</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkDFPHDEQRq0oKBCgTRltlW4v47W9vi0DAQI6ARIHlNbYno2c-M7E3hW5f58jdwI6qpnifa94jH3iMOEAzVcb0jBpABQACPWO7fFpC7UWXL7f_q1up7vsYym_AKQSID-wXd5Ou6ZRfI9dXufkRzeEtKxSX32vMaMNQ4qVXVVYLWhAm2JwFS1_hiVRJl-VIWP4jx-hCzGOpSqjHUIM5YDt9BgLHW7vPrs9PZkf_6hnV2fnx99mtRONVjXHpukIrdbScY_egiROApVwEsE6LzlI7FvCXgvpPSfpvFdgO3Q9eRT77MvG-5DTn5HKYBahOIoRl5TGYtqp5pxLeBPkndZKSL4GJxvQ5VRKpt485LDAvDIczFNq85TaPKdeDz5vzaNdkH_Bt23XQLcBHkOk1Rs6c3R-NX8trzfbUAb6-7zF_Nu0Wmhl7i_PDMzvLm7u1Mycin-cYpuD</recordid><startdate>200602</startdate><enddate>200602</enddate><creator>Povelainen, Mira</creator><creator>Miasnikov, Andrei N.</creator><general>WILEY-VCH Verlag</general><general>WILEY‐VCH Verlag</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QL</scope><scope>7QO</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>P64</scope><scope>7X8</scope></search><sort><creationdate>200602</creationdate><title>Production of D-arabitol by a metabolic engineered strain of Bacillus subtilis</title><author>Povelainen, Mira ; Miasnikov, Andrei N.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3275-1a229eab774c1dadb04e1e3a53c4a0bcd4104af6eaf734dd1e4cdd50b9acfeda3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2006</creationdate><topic>Bacillus subtilis</topic><topic>Bacillus subtilis - genetics</topic><topic>Bacillus subtilis - metabolism</topic><topic>D-Arabitol</topic><topic>D-Arabitol phosphate dehydrogenase</topic><topic>Enterococcus - enzymology</topic><topic>Enterococcus - genetics</topic><topic>Enterococcus avium</topic><topic>Genetic Enhancement - methods</topic><topic>Glucose - metabolism</topic><topic>Polyhydroxy alcohol</topic><topic>Protein Engineering - methods</topic><topic>Sugar Alcohol Dehydrogenases - genetics</topic><topic>Sugar Alcohol Dehydrogenases - metabolism</topic><topic>Sugar Alcohols - isolation & purification</topic><topic>Sugar Alcohols - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Povelainen, Mira</creatorcontrib><creatorcontrib>Miasnikov, Andrei N.</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Biotechnology Research Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Biotechnology journal</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Povelainen, Mira</au><au>Miasnikov, Andrei N.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Production of D-arabitol by a metabolic engineered strain of Bacillus subtilis</atitle><jtitle>Biotechnology journal</jtitle><addtitle>Biotechnology Journal</addtitle><date>2006-02</date><risdate>2006</risdate><volume>1</volume><issue>2</issue><spage>214</spage><epage>219</epage><pages>214-219</pages><issn>1860-6768</issn><eissn>1860-7314</eissn><abstract>A novel method for D‐arabitol production with a metabolically engineered Bacillus subtilis strain is described. 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| fulltext | fulltext |
| identifier | ISSN: 1860-6768 |
| ispartof | Biotechnology journal, 2006-02, Vol.1 (2), p.214-219 |
| issn | 1860-6768 1860-7314 |
| language | eng |
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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | Bacillus subtilis Bacillus subtilis - genetics Bacillus subtilis - metabolism D-Arabitol D-Arabitol phosphate dehydrogenase Enterococcus - enzymology Enterococcus - genetics Enterococcus avium Genetic Enhancement - methods Glucose - metabolism Polyhydroxy alcohol Protein Engineering - methods Sugar Alcohol Dehydrogenases - genetics Sugar Alcohol Dehydrogenases - metabolism Sugar Alcohols - isolation & purification Sugar Alcohols - metabolism |
| title | Production of D-arabitol by a metabolic engineered strain of Bacillus subtilis |
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