Vitamin E Is Essential for Mouse Placentation but Not for Embryonic Development Itself
Vitamin E (alpha-tocopherol) was discovered 80 years ago to be an indispensable nutrient for reproduction in the female. However, it has not been clarified when or where vitamin E is required during pregnancy. We examined the role of alpha-tocopherol in pregnancy using alpha-tocopherol transfer prot...
Gespeichert in:
| Veröffentlicht in: | Biology of reproduction 2005-11, Vol.73 (5), p.983-987 |
|---|---|
| Hauptverfasser: | , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 987 |
|---|---|
| container_issue | 5 |
| container_start_page | 983 |
| container_title | Biology of reproduction |
| container_volume | 73 |
| creator | Jishage, Kou-ichi Tachibe, Takanori Ito, Tsuneo Shibata, Norihito Suzuki, Shigeo Mori, Toshio Hani, Toshio Arai, Hiroyuki Suzuki, Hiroshi |
| description | Vitamin E (alpha-tocopherol) was discovered 80 years ago to be an indispensable nutrient for reproduction in the female. However, it has not been clarified when or where vitamin E is required during pregnancy. We examined the role of alpha-tocopherol in pregnancy using alpha-tocopherol transfer protein (Ttpa)-deficient mice fed specific alpha-tocopherol diets that led to daily, measurable change in plasma alpha-tocopherol levels from nearly normal to almost undetectable levels. A dietary supplement of alpha-tocopherol to pregnant Ttpa−/− (homozygous null) mice was shown to be essential for maintenance of pregnancy from 6.5 to 13.5 days postcoitum but found not to be crucial before or after this time span, which corresponds to initial development and maturation of the placenta. In addition, exposure to a low alpha-tocopherol environment after initiation of placental formation might result in necrosis of placental syncytiotrophoblast cells, followed by necrosis of fetal blood vessel endothelial cells. When Ttpa−/−-fertilized eggs were transferred into Ttpa+/+ (wild-type) recipients, plasma alpha-tocopherol concentrations in the Ttpa−/− fetuses were below the detection limit but the fetuses grew normally. These results indicate that alpha-tocopherol is indispensable for the proliferation and/or function of the placenta but not necessary for development of the embryo itself. |
| doi_str_mv | 10.1095/biolreprod.105.043018 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_68710458</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>68710458</sourcerecordid><originalsourceid>FETCH-LOGICAL-b458t-70ca76482c6ac38d4d213e4ceb5d7f37c272fdd42ebe06b36a03d72334a560cc3</originalsourceid><addsrcrecordid>eNqNkE1vEzEQhi0EoqH0J7TyBW5bbM_6I8eqDRCpfBygV8vrnW1dedepvSHqv8clkXLlZI_9zMyrh5Bzzi45W8pPXUgx4yanvtbykrXAuHlFFlyKZaOFMq_JgjGmGgAFJ-RdKY-M8RYEvCUnXNWr4WJB7u7C7MYw0RVdF7oqBac5uEiHlOm3tC1If0bn66ObQ5pot53p9zT_-16NXX5OU_D0Bv9gTJuxYnQ9F4zDe_JmcLHg2eE8Jb8_r35df21uf3xZX1_dNl0rzdxo5p1WrRFeOQ-mb3vBAVuPnez1ANoLLYa-bwV2yFQHyjHotQBonVTMezglH_dzq4inLZbZjqF4jNFNWNNbZTRndVUF5R70OZWScbCbHEaXny1n9kWoPQqttbR7obXv4rBg243YH7sOBivw4QC44l0cspt8KEdOCyaZ4UfuIdw_7EJGW0YXYx0LdrfbabDSLg1UDvZczZMm_M-YfwGQdp-P</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>68710458</pqid></control><display><type>article</type><title>Vitamin E Is Essential for Mouse Placentation but Not for Embryonic Development Itself</title><source>MEDLINE</source><source>BioOne Complete</source><source>Oxford University Press Journals All Titles (1996-Current)</source><source>EZB-FREE-00999 freely available EZB journals</source><creator>Jishage, Kou-ichi ; Tachibe, Takanori ; Ito, Tsuneo ; Shibata, Norihito ; Suzuki, Shigeo ; Mori, Toshio ; Hani, Toshio ; Arai, Hiroyuki ; Suzuki, Hiroshi</creator><creatorcontrib>Jishage, Kou-ichi ; Tachibe, Takanori ; Ito, Tsuneo ; Shibata, Norihito ; Suzuki, Shigeo ; Mori, Toshio ; Hani, Toshio ; Arai, Hiroyuki ; Suzuki, Hiroshi</creatorcontrib><description>Vitamin E (alpha-tocopherol) was discovered 80 years ago to be an indispensable nutrient for reproduction in the female. However, it has not been clarified when or where vitamin E is required during pregnancy. We examined the role of alpha-tocopherol in pregnancy using alpha-tocopherol transfer protein (Ttpa)-deficient mice fed specific alpha-tocopherol diets that led to daily, measurable change in plasma alpha-tocopherol levels from nearly normal to almost undetectable levels. A dietary supplement of alpha-tocopherol to pregnant Ttpa−/− (homozygous null) mice was shown to be essential for maintenance of pregnancy from 6.5 to 13.5 days postcoitum but found not to be crucial before or after this time span, which corresponds to initial development and maturation of the placenta. In addition, exposure to a low alpha-tocopherol environment after initiation of placental formation might result in necrosis of placental syncytiotrophoblast cells, followed by necrosis of fetal blood vessel endothelial cells. When Ttpa−/−-fertilized eggs were transferred into Ttpa+/+ (wild-type) recipients, plasma alpha-tocopherol concentrations in the Ttpa−/− fetuses were below the detection limit but the fetuses grew normally. These results indicate that alpha-tocopherol is indispensable for the proliferation and/or function of the placenta but not necessary for development of the embryo itself.</description><identifier>ISSN: 0006-3363</identifier><identifier>EISSN: 1529-7268</identifier><identifier>DOI: 10.1095/biolreprod.105.043018</identifier><identifier>PMID: 16014812</identifier><identifier>CODEN: BIREBV</identifier><language>eng</language><publisher>Madison, WI: Society for the Study of Reproduction</publisher><subject>Animals ; Biological and medical sciences ; Carrier Proteins - drug effects ; Carrier Proteins - genetics ; Carrier Proteins - metabolism ; CONTENTS ; Early stages. Segmentation. Gastrulation. Neurulation ; embryo ; Embryo, Mammalian - metabolism ; Embryology: invertebrates and vertebrates. Teratology ; Embryonic Development ; Female ; Fundamental and applied biological sciences. Psychology ; Gestational Age ; Male ; Mice ; Mice, Inbred ICR ; Mice, Mutant Strains ; placenta ; Placenta - pathology ; Placenta - physiology ; Pregnancy ; Pregnancy, Animal ; syncytiotrophoblast ; trophoblast ; Vertebrates: reproduction ; Vitamin E - blood ; Vitamin E - pharmacology ; Vitamin E - physiology</subject><ispartof>Biology of reproduction, 2005-11, Vol.73 (5), p.983-987</ispartof><rights>Society for the Study of Reproduction</rights><rights>2005 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-b458t-70ca76482c6ac38d4d213e4ceb5d7f37c272fdd42ebe06b36a03d72334a560cc3</citedby><cites>FETCH-LOGICAL-b458t-70ca76482c6ac38d4d213e4ceb5d7f37c272fdd42ebe06b36a03d72334a560cc3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://bioone.org/doi/pdf/10.1095/biolreprod.105.043018$$EPDF$$P50$$Gbioone$$H</linktopdf><link.rule.ids>314,776,780,26957,27903,27904,52341</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=17205081$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16014812$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Jishage, Kou-ichi</creatorcontrib><creatorcontrib>Tachibe, Takanori</creatorcontrib><creatorcontrib>Ito, Tsuneo</creatorcontrib><creatorcontrib>Shibata, Norihito</creatorcontrib><creatorcontrib>Suzuki, Shigeo</creatorcontrib><creatorcontrib>Mori, Toshio</creatorcontrib><creatorcontrib>Hani, Toshio</creatorcontrib><creatorcontrib>Arai, Hiroyuki</creatorcontrib><creatorcontrib>Suzuki, Hiroshi</creatorcontrib><title>Vitamin E Is Essential for Mouse Placentation but Not for Embryonic Development Itself</title><title>Biology of reproduction</title><addtitle>Biol Reprod</addtitle><description>Vitamin E (alpha-tocopherol) was discovered 80 years ago to be an indispensable nutrient for reproduction in the female. However, it has not been clarified when or where vitamin E is required during pregnancy. We examined the role of alpha-tocopherol in pregnancy using alpha-tocopherol transfer protein (Ttpa)-deficient mice fed specific alpha-tocopherol diets that led to daily, measurable change in plasma alpha-tocopherol levels from nearly normal to almost undetectable levels. A dietary supplement of alpha-tocopherol to pregnant Ttpa−/− (homozygous null) mice was shown to be essential for maintenance of pregnancy from 6.5 to 13.5 days postcoitum but found not to be crucial before or after this time span, which corresponds to initial development and maturation of the placenta. In addition, exposure to a low alpha-tocopherol environment after initiation of placental formation might result in necrosis of placental syncytiotrophoblast cells, followed by necrosis of fetal blood vessel endothelial cells. When Ttpa−/−-fertilized eggs were transferred into Ttpa+/+ (wild-type) recipients, plasma alpha-tocopherol concentrations in the Ttpa−/− fetuses were below the detection limit but the fetuses grew normally. These results indicate that alpha-tocopherol is indispensable for the proliferation and/or function of the placenta but not necessary for development of the embryo itself.</description><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Carrier Proteins - drug effects</subject><subject>Carrier Proteins - genetics</subject><subject>Carrier Proteins - metabolism</subject><subject>CONTENTS</subject><subject>Early stages. Segmentation. Gastrulation. Neurulation</subject><subject>embryo</subject><subject>Embryo, Mammalian - metabolism</subject><subject>Embryology: invertebrates and vertebrates. Teratology</subject><subject>Embryonic Development</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Gestational Age</subject><subject>Male</subject><subject>Mice</subject><subject>Mice, Inbred ICR</subject><subject>Mice, Mutant Strains</subject><subject>placenta</subject><subject>Placenta - pathology</subject><subject>Placenta - physiology</subject><subject>Pregnancy</subject><subject>Pregnancy, Animal</subject><subject>syncytiotrophoblast</subject><subject>trophoblast</subject><subject>Vertebrates: reproduction</subject><subject>Vitamin E - blood</subject><subject>Vitamin E - pharmacology</subject><subject>Vitamin E - physiology</subject><issn>0006-3363</issn><issn>1529-7268</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkE1vEzEQhi0EoqH0J7TyBW5bbM_6I8eqDRCpfBygV8vrnW1dedepvSHqv8clkXLlZI_9zMyrh5Bzzi45W8pPXUgx4yanvtbykrXAuHlFFlyKZaOFMq_JgjGmGgAFJ-RdKY-M8RYEvCUnXNWr4WJB7u7C7MYw0RVdF7oqBac5uEiHlOm3tC1If0bn66ObQ5pot53p9zT_-16NXX5OU_D0Bv9gTJuxYnQ9F4zDe_JmcLHg2eE8Jb8_r35df21uf3xZX1_dNl0rzdxo5p1WrRFeOQ-mb3vBAVuPnez1ANoLLYa-bwV2yFQHyjHotQBonVTMezglH_dzq4inLZbZjqF4jNFNWNNbZTRndVUF5R70OZWScbCbHEaXny1n9kWoPQqttbR7obXv4rBg243YH7sOBivw4QC44l0cspt8KEdOCyaZ4UfuIdw_7EJGW0YXYx0LdrfbabDSLg1UDvZczZMm_M-YfwGQdp-P</recordid><startdate>20051101</startdate><enddate>20051101</enddate><creator>Jishage, Kou-ichi</creator><creator>Tachibe, Takanori</creator><creator>Ito, Tsuneo</creator><creator>Shibata, Norihito</creator><creator>Suzuki, Shigeo</creator><creator>Mori, Toshio</creator><creator>Hani, Toshio</creator><creator>Arai, Hiroyuki</creator><creator>Suzuki, Hiroshi</creator><general>Society for the Study of Reproduction</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20051101</creationdate><title>Vitamin E Is Essential for Mouse Placentation but Not for Embryonic Development Itself</title><author>Jishage, Kou-ichi ; Tachibe, Takanori ; Ito, Tsuneo ; Shibata, Norihito ; Suzuki, Shigeo ; Mori, Toshio ; Hani, Toshio ; Arai, Hiroyuki ; Suzuki, Hiroshi</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-b458t-70ca76482c6ac38d4d213e4ceb5d7f37c272fdd42ebe06b36a03d72334a560cc3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Carrier Proteins - drug effects</topic><topic>Carrier Proteins - genetics</topic><topic>Carrier Proteins - metabolism</topic><topic>CONTENTS</topic><topic>Early stages. Segmentation. Gastrulation. Neurulation</topic><topic>embryo</topic><topic>Embryo, Mammalian - metabolism</topic><topic>Embryology: invertebrates and vertebrates. Teratology</topic><topic>Embryonic Development</topic><topic>Female</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Gestational Age</topic><topic>Male</topic><topic>Mice</topic><topic>Mice, Inbred ICR</topic><topic>Mice, Mutant Strains</topic><topic>placenta</topic><topic>Placenta - pathology</topic><topic>Placenta - physiology</topic><topic>Pregnancy</topic><topic>Pregnancy, Animal</topic><topic>syncytiotrophoblast</topic><topic>trophoblast</topic><topic>Vertebrates: reproduction</topic><topic>Vitamin E - blood</topic><topic>Vitamin E - pharmacology</topic><topic>Vitamin E - physiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Jishage, Kou-ichi</creatorcontrib><creatorcontrib>Tachibe, Takanori</creatorcontrib><creatorcontrib>Ito, Tsuneo</creatorcontrib><creatorcontrib>Shibata, Norihito</creatorcontrib><creatorcontrib>Suzuki, Shigeo</creatorcontrib><creatorcontrib>Mori, Toshio</creatorcontrib><creatorcontrib>Hani, Toshio</creatorcontrib><creatorcontrib>Arai, Hiroyuki</creatorcontrib><creatorcontrib>Suzuki, Hiroshi</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Biology of reproduction</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Jishage, Kou-ichi</au><au>Tachibe, Takanori</au><au>Ito, Tsuneo</au><au>Shibata, Norihito</au><au>Suzuki, Shigeo</au><au>Mori, Toshio</au><au>Hani, Toshio</au><au>Arai, Hiroyuki</au><au>Suzuki, Hiroshi</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Vitamin E Is Essential for Mouse Placentation but Not for Embryonic Development Itself</atitle><jtitle>Biology of reproduction</jtitle><addtitle>Biol Reprod</addtitle><date>2005-11-01</date><risdate>2005</risdate><volume>73</volume><issue>5</issue><spage>983</spage><epage>987</epage><pages>983-987</pages><issn>0006-3363</issn><eissn>1529-7268</eissn><coden>BIREBV</coden><abstract>Vitamin E (alpha-tocopherol) was discovered 80 years ago to be an indispensable nutrient for reproduction in the female. However, it has not been clarified when or where vitamin E is required during pregnancy. We examined the role of alpha-tocopherol in pregnancy using alpha-tocopherol transfer protein (Ttpa)-deficient mice fed specific alpha-tocopherol diets that led to daily, measurable change in plasma alpha-tocopherol levels from nearly normal to almost undetectable levels. A dietary supplement of alpha-tocopherol to pregnant Ttpa−/− (homozygous null) mice was shown to be essential for maintenance of pregnancy from 6.5 to 13.5 days postcoitum but found not to be crucial before or after this time span, which corresponds to initial development and maturation of the placenta. In addition, exposure to a low alpha-tocopherol environment after initiation of placental formation might result in necrosis of placental syncytiotrophoblast cells, followed by necrosis of fetal blood vessel endothelial cells. When Ttpa−/−-fertilized eggs were transferred into Ttpa+/+ (wild-type) recipients, plasma alpha-tocopherol concentrations in the Ttpa−/− fetuses were below the detection limit but the fetuses grew normally. These results indicate that alpha-tocopherol is indispensable for the proliferation and/or function of the placenta but not necessary for development of the embryo itself.</abstract><cop>Madison, WI</cop><pub>Society for the Study of Reproduction</pub><pmid>16014812</pmid><doi>10.1095/biolreprod.105.043018</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0006-3363 |
| ispartof | Biology of reproduction, 2005-11, Vol.73 (5), p.983-987 |
| issn | 0006-3363 1529-7268 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_68710458 |
| source | MEDLINE; BioOne Complete; Oxford University Press Journals All Titles (1996-Current); EZB-FREE-00999 freely available EZB journals |
| subjects | Animals Biological and medical sciences Carrier Proteins - drug effects Carrier Proteins - genetics Carrier Proteins - metabolism CONTENTS Early stages. Segmentation. Gastrulation. Neurulation embryo Embryo, Mammalian - metabolism Embryology: invertebrates and vertebrates. Teratology Embryonic Development Female Fundamental and applied biological sciences. Psychology Gestational Age Male Mice Mice, Inbred ICR Mice, Mutant Strains placenta Placenta - pathology Placenta - physiology Pregnancy Pregnancy, Animal syncytiotrophoblast trophoblast Vertebrates: reproduction Vitamin E - blood Vitamin E - pharmacology Vitamin E - physiology |
| title | Vitamin E Is Essential for Mouse Placentation but Not for Embryonic Development Itself |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-26T10%3A57%3A22IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Vitamin%20E%20Is%20Essential%20for%20Mouse%20Placentation%20but%20Not%20for%20Embryonic%20Development%20Itself&rft.jtitle=Biology%20of%20reproduction&rft.au=Jishage,%20Kou-ichi&rft.date=2005-11-01&rft.volume=73&rft.issue=5&rft.spage=983&rft.epage=987&rft.pages=983-987&rft.issn=0006-3363&rft.eissn=1529-7268&rft.coden=BIREBV&rft_id=info:doi/10.1095/biolreprod.105.043018&rft_dat=%3Cproquest_cross%3E68710458%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=68710458&rft_id=info:pmid/16014812&rfr_iscdi=true |