Antagonism of CXCR3 inhibits lung metastasis in a murine model of metastatic breast cancer

Tumor cells aberrantly express chemokines and/or chemokine receptors, and some may promote tumor growth and metastasis. We examined the expression and function of chemokine receptor CXCR3 in a syngeneic murine model of metastatic breast cancer. By flow cytometry, CXCR3 was detected in all murine mam...

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Veröffentlicht in:	Cancer research (Chicago, Ill.) Ill.), 2006-08, Vol.66 (15), p.7701-7707
Hauptverfasser:	WALSER, Tonya C, RIFAT, Salah, XINRONG MA, KUNDU, Namita, WARD, Chris, GOLOUBEVA, Olga, JOHNSON, Michael G, MEDINA, Julio C, COLLINS, Tassie L, FULTON, Amy M
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenocarcinoma - immunology Adenocarcinoma - prevention & control Adenocarcinoma - secondary Animals Antineoplastic agents Biological and medical sciences Breast Neoplasms - immunology Breast Neoplasms - pathology Cell Line, Tumor Disease Models, Animal Female Gynecology. Andrology. Obstetrics Humans Lung Neoplasms - immunology Lung Neoplasms - prevention & control Lung Neoplasms - secondary Mammary gland diseases Mammary Neoplasms, Experimental - immunology Mammary Neoplasms, Experimental - pathology Medical sciences Mice Mice, Inbred BALB C Mice, Inbred C3H Mice, SCID Pharmacology. Drug treatments Receptors, Chemokine - antagonists & inhibitors Receptors, Chemokine - biosynthesis Receptors, Chemokine - immunology Receptors, CXCR3 Tumors
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