The DNA N-glycosylase MED1 exhibits preference for halogenated pyrimidines and is involved in the cytotoxicity of 5-iododeoxyuridine

The base excision repair protein MED1 (also known as MBD4), an interactor with the mismatch repair protein MLH1, has a central role in the maintenance of genomic stability with dual functions in DNA damage response and repair. MED1 acts as a thymine and uracil DNA N-glycosylase on T:G and U:G mismat...

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Veröffentlicht in:	Cancer research (Chicago, Ill.) Ill.), 2006-08, Vol.66 (15), p.7686-7693
Hauptverfasser:	Turner, David P, Cortellino, Salvatore, Schupp, Jane E, Caretti, Elena, Loh, Tamalette, Kinsella, Timothy J, Bellacosa, Alfonso
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Base Pair Mismatch Cell Line CpG Islands Embryo, Mammalian Endodeoxyribonucleases - genetics Endodeoxyribonucleases - metabolism Gene Silencing Humans Idoxuridine - metabolism Idoxuridine - pharmacology Mice Pyrimidines - metabolism Pyrimidines - pharmacology Substrate Specificity
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