Synthesis and biological evaluation of novel ( l)-α-amino acid methyl ester, heteroalkyl, and aryl substituted 1,4-naphthoquinone derivatives as antifungal and antibacterial agents

The synthesis, antifungal, and antibacterial activities of 3– 15 are described. A series of ( S)- N-(1,4-naphthoquinon-2-yl)-α-amino acid methyl esters 3– 9, 2- N, N-dialkylamino-1,4-naphthoquinones 10– 11 and 2-hydroxy-3-(2′-mercaptoimidazolyl)-1,4-naphthoquinones and their cyclic analogs 12– 15 we...

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