Cerebral Palsy in a Term Population: Risk Factors and Neuroimaging Findings
The purpose of this work was to study risk factors and neuroimaging characteristics of cerebral palsy in term and near-term infants. Among a cohort of 334,339 infants > or = 36 weeks' gestation born at Kaiser Permanente Medical Care Program in northern California in 1991-2003, we identified...
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| Veröffentlicht in: | Pediatrics (Evanston) 2006-08, Vol.118 (2), p.690-697 |
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| creator | Wu, Yvonne W Croen, Lisa A Shah, Sameer J Newman, Thomas B Najjar, Daniel V |
| description | The purpose of this work was to study risk factors and neuroimaging characteristics of cerebral palsy in term and near-term infants.
Among a cohort of 334,339 infants > or = 36 weeks' gestation born at Kaiser Permanente Medical Care Program in northern California in 1991-2003, we identified infants with cerebral palsy and obtained clinical data from electronic and medical charts. Risk factors for cerebral palsy among infants with different brain abnormalities were compared using polytomous logistic regression.
Of 377 infants with cerebral palsy (prevalence: 1.1 per 1000), 273 (72%) received a head computed tomography or MRI. Abnormalities included focal arterial infarction (22%), brain malformation (14%), and periventricular white matter abnormalities (12%). Independent risk factors for cerebral palsy were maternal age > 35, black race, and intrauterine growth restriction. Intrauterine growth restriction was more strongly associated with periventricular white matter injury than with other neuroimaging findings. Nighttime delivery was associated with cerebral palsy accompanied by generalized brain atrophy but not with cerebral palsy accompanied by other brain lesions.
Cerebral palsy is a heterogeneous syndrome with focal arterial infarction and brain malformation representing the most common neuroimaging abnormalities in term and near-term infants. Risk factors for cerebral palsy differ depending on the type of underlying brain abnormality. |
| doi_str_mv | 10.1542/peds.2006-0278 |
| format | Article |
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Among a cohort of 334,339 infants > or = 36 weeks' gestation born at Kaiser Permanente Medical Care Program in northern California in 1991-2003, we identified infants with cerebral palsy and obtained clinical data from electronic and medical charts. Risk factors for cerebral palsy among infants with different brain abnormalities were compared using polytomous logistic regression.
Of 377 infants with cerebral palsy (prevalence: 1.1 per 1000), 273 (72%) received a head computed tomography or MRI. Abnormalities included focal arterial infarction (22%), brain malformation (14%), and periventricular white matter abnormalities (12%). Independent risk factors for cerebral palsy were maternal age > 35, black race, and intrauterine growth restriction. Intrauterine growth restriction was more strongly associated with periventricular white matter injury than with other neuroimaging findings. Nighttime delivery was associated with cerebral palsy accompanied by generalized brain atrophy but not with cerebral palsy accompanied by other brain lesions.
Cerebral palsy is a heterogeneous syndrome with focal arterial infarction and brain malformation representing the most common neuroimaging abnormalities in term and near-term infants. Risk factors for cerebral palsy differ depending on the type of underlying brain abnormality.</description><identifier>ISSN: 0031-4005</identifier><identifier>EISSN: 1098-4275</identifier><identifier>DOI: 10.1542/peds.2006-0278</identifier><identifier>PMID: 16882824</identifier><identifier>CODEN: PEDIAU</identifier><language>eng</language><publisher>Elk Grove Village, IL: Am Acad Pediatrics</publisher><subject>Adult ; Atrophy ; Biological and medical sciences ; Birth weight ; Brain - abnormalities ; Brain - diagnostic imaging ; Brain - pathology ; Brain Damage, Chronic - diagnostic imaging ; Brain Damage, Chronic - epidemiology ; Brain Damage, Chronic - pathology ; California - epidemiology ; Cerebral Infarction - congenital ; Cerebral Infarction - diagnostic imaging ; Cerebral Infarction - epidemiology ; Cerebral Infarction - pathology ; Cerebral palsy ; Cerebral Palsy - diagnostic imaging ; Cerebral Palsy - epidemiology ; Cerebral Palsy - pathology ; Children & youth ; Cohort Studies ; Delivery, Obstetric - statistics & numerical data ; Development and progression ; Diagnosis ; Ethnic Groups - statistics & numerical data ; Female ; Fetal Growth Retardation - epidemiology ; General aspects ; Headache. Facial pains. Syncopes. Epilepsia. Intracranial hypertension. Brain oedema. Cerebral palsy ; Health aspects ; Humans ; Infant, Newborn ; Magnetic Resonance Imaging ; Maternal Age ; Medical imaging ; Medical sciences ; Miscellaneous ; Nervous system (semeiology, syndromes) ; Neuroimaging ; Neurology ; Patient outcomes ; Pediatrics ; Pregnancy ; Public health. Hygiene ; Public health. Hygiene-occupational medicine ; Risk ; Risk Factors ; Term Birth ; Time Factors ; Tomography, X-Ray Computed</subject><ispartof>Pediatrics (Evanston), 2006-08, Vol.118 (2), p.690-697</ispartof><rights>2006 INIST-CNRS</rights><rights>COPYRIGHT 2006 American Academy of Pediatrics</rights><rights>Copyright American Academy of Pediatrics Aug 2006</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c635t-cf187ca213e1cd65330d492a451853beed87aa664cc9eb1d6971317b1e016d083</citedby><cites>FETCH-LOGICAL-c635t-cf187ca213e1cd65330d492a451853beed87aa664cc9eb1d6971317b1e016d083</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=18009163$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16882824$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Wu, Yvonne W</creatorcontrib><creatorcontrib>Croen, Lisa A</creatorcontrib><creatorcontrib>Shah, Sameer J</creatorcontrib><creatorcontrib>Newman, Thomas B</creatorcontrib><creatorcontrib>Najjar, Daniel V</creatorcontrib><title>Cerebral Palsy in a Term Population: Risk Factors and Neuroimaging Findings</title><title>Pediatrics (Evanston)</title><addtitle>Pediatrics</addtitle><description>The purpose of this work was to study risk factors and neuroimaging characteristics of cerebral palsy in term and near-term infants.
Among a cohort of 334,339 infants > or = 36 weeks' gestation born at Kaiser Permanente Medical Care Program in northern California in 1991-2003, we identified infants with cerebral palsy and obtained clinical data from electronic and medical charts. Risk factors for cerebral palsy among infants with different brain abnormalities were compared using polytomous logistic regression.
Of 377 infants with cerebral palsy (prevalence: 1.1 per 1000), 273 (72%) received a head computed tomography or MRI. Abnormalities included focal arterial infarction (22%), brain malformation (14%), and periventricular white matter abnormalities (12%). Independent risk factors for cerebral palsy were maternal age > 35, black race, and intrauterine growth restriction. Intrauterine growth restriction was more strongly associated with periventricular white matter injury than with other neuroimaging findings. Nighttime delivery was associated with cerebral palsy accompanied by generalized brain atrophy but not with cerebral palsy accompanied by other brain lesions.
Cerebral palsy is a heterogeneous syndrome with focal arterial infarction and brain malformation representing the most common neuroimaging abnormalities in term and near-term infants. Risk factors for cerebral palsy differ depending on the type of underlying brain abnormality.</description><subject>Adult</subject><subject>Atrophy</subject><subject>Biological and medical sciences</subject><subject>Birth weight</subject><subject>Brain - abnormalities</subject><subject>Brain - diagnostic imaging</subject><subject>Brain - pathology</subject><subject>Brain Damage, Chronic - diagnostic imaging</subject><subject>Brain Damage, Chronic - epidemiology</subject><subject>Brain Damage, Chronic - pathology</subject><subject>California - epidemiology</subject><subject>Cerebral Infarction - congenital</subject><subject>Cerebral Infarction - diagnostic imaging</subject><subject>Cerebral Infarction - epidemiology</subject><subject>Cerebral Infarction - pathology</subject><subject>Cerebral palsy</subject><subject>Cerebral Palsy - diagnostic imaging</subject><subject>Cerebral Palsy - epidemiology</subject><subject>Cerebral Palsy - pathology</subject><subject>Children & youth</subject><subject>Cohort Studies</subject><subject>Delivery, Obstetric - statistics & numerical data</subject><subject>Development and progression</subject><subject>Diagnosis</subject><subject>Ethnic Groups - statistics & numerical data</subject><subject>Female</subject><subject>Fetal Growth Retardation - epidemiology</subject><subject>General aspects</subject><subject>Headache. Facial pains. Syncopes. Epilepsia. Intracranial hypertension. Brain oedema. Cerebral palsy</subject><subject>Health aspects</subject><subject>Humans</subject><subject>Infant, Newborn</subject><subject>Magnetic Resonance Imaging</subject><subject>Maternal Age</subject><subject>Medical imaging</subject><subject>Medical sciences</subject><subject>Miscellaneous</subject><subject>Nervous system (semeiology, syndromes)</subject><subject>Neuroimaging</subject><subject>Neurology</subject><subject>Patient outcomes</subject><subject>Pediatrics</subject><subject>Pregnancy</subject><subject>Public health. Hygiene</subject><subject>Public health. Hygiene-occupational medicine</subject><subject>Risk</subject><subject>Risk Factors</subject><subject>Term Birth</subject><subject>Time Factors</subject><subject>Tomography, X-Ray Computed</subject><issn>0031-4005</issn><issn>1098-4275</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2006</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFktGLEzEQxoMoXq2--iiLoODD1kmyyWZ9O4o9xeIdcj6HNDu7l3Ob1GQXvf_elCvUk4LkYcLw-2Ymk4-QlxQWVFTs_Q7btGAAsgRWq0dkRqFRZcVq8ZjMADgtKwBxRp6ldAsAlajZU3JGpVJMsWpGviwx4iaaobgyQ7ornC9McY1xW1yF3TSY0QX_ofjm0o9iZewYYiqMb4uvOMXgtqZ3vi9Wzrc5pufkSZeL4ItDnJPvq4_Xy0_l-vLi8_J8XVrJxVjajqraGkY5UttKwTm0VcNMJagSfIPYqtoYKStrG9zQVjY15bTeUAQqW1B8Tt7e193F8HPCNOqtSxaHwXgMU9JS1ZBF8r8gg5rxOk8wJ6__AW_DFH1-hGZMcZkRmqHyHurNgNr5LozR2B495vUFj53L6XMqpKgaoZrML07w-bS4dfak4N0DQWZG_D32ZkpJq4v1Q7Y8xdowDNijzvteXp4cxsaQUsRO72L-v3inKei9k_TeSXrvJL13Uha8Oqxk2myxPeIH62TgzQEwyZqhi8Zbl46cAmio5MfON66_-eUi7js5M0Zn019XSpVmWjbA_wC879zp</recordid><startdate>20060801</startdate><enddate>20060801</enddate><creator>Wu, Yvonne W</creator><creator>Croen, Lisa A</creator><creator>Shah, Sameer J</creator><creator>Newman, Thomas B</creator><creator>Najjar, Daniel V</creator><general>Am Acad Pediatrics</general><general>American Academy of Pediatrics</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>8GL</scope><scope>7TS</scope><scope>7U9</scope><scope>H94</scope><scope>K9.</scope><scope>M7N</scope><scope>NAPCQ</scope><scope>U9A</scope><scope>7QO</scope><scope>7TK</scope><scope>7U1</scope><scope>7U2</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>P64</scope><scope>7X8</scope></search><sort><creationdate>20060801</creationdate><title>Cerebral Palsy in a Term Population: Risk Factors and Neuroimaging Findings</title><author>Wu, Yvonne W ; Croen, Lisa A ; Shah, Sameer J ; Newman, Thomas B ; Najjar, Daniel V</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c635t-cf187ca213e1cd65330d492a451853beed87aa664cc9eb1d6971317b1e016d083</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2006</creationdate><topic>Adult</topic><topic>Atrophy</topic><topic>Biological and medical sciences</topic><topic>Birth weight</topic><topic>Brain - abnormalities</topic><topic>Brain - diagnostic imaging</topic><topic>Brain - pathology</topic><topic>Brain Damage, Chronic - diagnostic imaging</topic><topic>Brain Damage, Chronic - epidemiology</topic><topic>Brain Damage, Chronic - pathology</topic><topic>California - epidemiology</topic><topic>Cerebral Infarction - congenital</topic><topic>Cerebral Infarction - diagnostic imaging</topic><topic>Cerebral Infarction - epidemiology</topic><topic>Cerebral Infarction - pathology</topic><topic>Cerebral palsy</topic><topic>Cerebral Palsy - diagnostic imaging</topic><topic>Cerebral Palsy - epidemiology</topic><topic>Cerebral Palsy - pathology</topic><topic>Children & youth</topic><topic>Cohort Studies</topic><topic>Delivery, Obstetric - statistics & numerical data</topic><topic>Development and progression</topic><topic>Diagnosis</topic><topic>Ethnic Groups - statistics & numerical data</topic><topic>Female</topic><topic>Fetal Growth Retardation - epidemiology</topic><topic>General aspects</topic><topic>Headache. Facial pains. Syncopes. Epilepsia. Intracranial hypertension. Brain oedema. Cerebral palsy</topic><topic>Health aspects</topic><topic>Humans</topic><topic>Infant, Newborn</topic><topic>Magnetic Resonance Imaging</topic><topic>Maternal Age</topic><topic>Medical imaging</topic><topic>Medical sciences</topic><topic>Miscellaneous</topic><topic>Nervous system (semeiology, syndromes)</topic><topic>Neuroimaging</topic><topic>Neurology</topic><topic>Patient outcomes</topic><topic>Pediatrics</topic><topic>Pregnancy</topic><topic>Public health. Hygiene</topic><topic>Public health. 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Among a cohort of 334,339 infants > or = 36 weeks' gestation born at Kaiser Permanente Medical Care Program in northern California in 1991-2003, we identified infants with cerebral palsy and obtained clinical data from electronic and medical charts. Risk factors for cerebral palsy among infants with different brain abnormalities were compared using polytomous logistic regression.
Of 377 infants with cerebral palsy (prevalence: 1.1 per 1000), 273 (72%) received a head computed tomography or MRI. Abnormalities included focal arterial infarction (22%), brain malformation (14%), and periventricular white matter abnormalities (12%). Independent risk factors for cerebral palsy were maternal age > 35, black race, and intrauterine growth restriction. Intrauterine growth restriction was more strongly associated with periventricular white matter injury than with other neuroimaging findings. Nighttime delivery was associated with cerebral palsy accompanied by generalized brain atrophy but not with cerebral palsy accompanied by other brain lesions.
Cerebral palsy is a heterogeneous syndrome with focal arterial infarction and brain malformation representing the most common neuroimaging abnormalities in term and near-term infants. Risk factors for cerebral palsy differ depending on the type of underlying brain abnormality.</abstract><cop>Elk Grove Village, IL</cop><pub>Am Acad Pediatrics</pub><pmid>16882824</pmid><doi>10.1542/peds.2006-0278</doi><tpages>8</tpages></addata></record> |
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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
| subjects | Adult Atrophy Biological and medical sciences Birth weight Brain - abnormalities Brain - diagnostic imaging Brain - pathology Brain Damage, Chronic - diagnostic imaging Brain Damage, Chronic - epidemiology Brain Damage, Chronic - pathology California - epidemiology Cerebral Infarction - congenital Cerebral Infarction - diagnostic imaging Cerebral Infarction - epidemiology Cerebral Infarction - pathology Cerebral palsy Cerebral Palsy - diagnostic imaging Cerebral Palsy - epidemiology Cerebral Palsy - pathology Children & youth Cohort Studies Delivery, Obstetric - statistics & numerical data Development and progression Diagnosis Ethnic Groups - statistics & numerical data Female Fetal Growth Retardation - epidemiology General aspects Headache. Facial pains. Syncopes. Epilepsia. Intracranial hypertension. Brain oedema. Cerebral palsy Health aspects Humans Infant, Newborn Magnetic Resonance Imaging Maternal Age Medical imaging Medical sciences Miscellaneous Nervous system (semeiology, syndromes) Neuroimaging Neurology Patient outcomes Pediatrics Pregnancy Public health. Hygiene Public health. Hygiene-occupational medicine Risk Risk Factors Term Birth Time Factors Tomography, X-Ray Computed |
| title | Cerebral Palsy in a Term Population: Risk Factors and Neuroimaging Findings |
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