RGS4 and RGS5 Are in vivo Substrates of the N-End Rule Pathway

The ATE1-encoded Arg-transferase mediates conjugation of Arg to N-terminal Asp, Glu, and Cys of certain eukaryotic proteins, yielding N-terminal Arg that can act as a degradation signal for the ubiquitin-dependent N-end rule pathway. We have previously shown that mouse ATE1-/-embryos die with defect...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2005-10, Vol.102 (42), p.15030-15035
Hauptverfasser:	Min Jae Lee, Tasaki, Takafumi, Kayoko Moroi, An, Jee Young, Kimura, Sadao, Davydov, Ilia V., Kwon, Yong Tae
Format:	Artikel
Sprache:	eng
Schlagworte:	Aminoacyltransferases - genetics Aminoacyltransferases - metabolism Animals Antibodies Biochemistry Biological Sciences Cell growth Cysteine - metabolism Embryos Eukaryotes GTP-Binding Proteins - metabolism Heart Hypoxia Immunoblotting Mice Mice, Knockout Oxidation Proteins Reticulocytes RGS proteins RGS Proteins - genetics RGS Proteins - metabolism Second Messenger Systems - physiology Signal transduction Ubiquitin - metabolism Ubiquitin-Protein Ligases - metabolism Western blotting
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