The circadian rhythm of glucocorticoids is regulated by a gating mechanism residing in the adrenal cortical clock
In mammals, the master clock of the suprachiasmatic nuclei (SCN) and subordinate clocks found throughout the body coordinate circadian rhythms of behavior and physiology. We characterize the clock of the adrenal, an important endocrine gland that synchronizes physiological and metabolic rhythms. Clo...
Gespeichert in:
| Veröffentlicht in: | Cell metabolism 2006-08, Vol.4 (2), p.163-173 |
|---|---|
| Hauptverfasser: | , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 173 |
|---|---|
| container_issue | 2 |
| container_start_page | 163 |
| container_title | Cell metabolism |
| container_volume | 4 |
| creator | Oster, Henrik Damerow, Sebastian Kiessling, Silke Jakubcakova, Vladimira Abraham, Diya Tian, Jiong Hoffmann, Matthias W. Eichele, Gregor |
| description | In mammals, the master clock of the
suprachiasmatic nuclei (SCN) and subordinate clocks found throughout the body coordinate circadian rhythms of behavior and physiology. We characterize the clock of the adrenal, an important endocrine gland that synchronizes physiological and metabolic rhythms. Clock gene expression was detected in the outer adrenal cortex prefiguring a role of the clock in regulating gluco- and mineral corticoid biogenesis. In
Per2/Cry1 double mutant mice, which lack a circadian clock, hypothalamus/pituitary/adrenal axis regulation was defective. Organ culture and tissue transplantation suggest that the adrenal pacemaker gates glucocorticoid production in response to adrenocorticotropin (ACTH). In vivo the adrenal circadian clock can be entrained by light. Transcriptome profiling identified rhythmically expressed genes located at diverse nodes of steroid biogenesis that may mediate gating of the ACTH response by the adrenal clock. |
| doi_str_mv | 10.1016/j.cmet.2006.07.002 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_68706483</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S1550413106002415</els_id><sourcerecordid>68706483</sourcerecordid><originalsourceid>FETCH-LOGICAL-c464t-77ade22641f18c6b94123160fabd7e78ffa699f9289173f8a8f0e887ea4aee553</originalsourceid><addsrcrecordid>eNp9kE1r3DAQhkVJaT7aP9BD0Ck3u_qyJEMvJaRtYKGX9Cy00mhXG9tKJDmw_742u5BbTzPMvPPAPAh9paSlhMpvh9aNUFtGiGyJaglhH9AV7TlrlGDkYum7jjSCcnqJrks5EMIl7_kndEml7kknxBV6fdoDdjE766OdcN4f637EKeDdMLvkUq7RpegLjgVn2M2DreDx9ogt3tkapx0ewe3tFMu47Ev06yhOuC5Y6zNMdsAnytoMyT1_Rh-DHQp8Odcb9Pfnw9P972bz59fj_Y9N44QUtVHKemBMChqodnLbC8o4lSTYrVegdAhW9n3ome6p4kFbHQhorcAKC9B1_AbdnbgvOb3OUKoZY3EwDHaCNBcjtSJSaL4E2SnociolQzAvOY42Hw0lZhVtDmYVbVbRhiiziF6Obs_0eTuCfz85m10C308BWH58i5BNcREmBz5mcNX4FP_H_wdfdZCw</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>68706483</pqid></control><display><type>article</type><title>The circadian rhythm of glucocorticoids is regulated by a gating mechanism residing in the adrenal cortical clock</title><source>MEDLINE</source><source>Cell Press Free Archives</source><source>Elsevier ScienceDirect Journals</source><source>EZB-FREE-00999 freely available EZB journals</source><creator>Oster, Henrik ; Damerow, Sebastian ; Kiessling, Silke ; Jakubcakova, Vladimira ; Abraham, Diya ; Tian, Jiong ; Hoffmann, Matthias W. ; Eichele, Gregor</creator><creatorcontrib>Oster, Henrik ; Damerow, Sebastian ; Kiessling, Silke ; Jakubcakova, Vladimira ; Abraham, Diya ; Tian, Jiong ; Hoffmann, Matthias W. ; Eichele, Gregor</creatorcontrib><description>In mammals, the master clock of the
suprachiasmatic nuclei (SCN) and subordinate clocks found throughout the body coordinate circadian rhythms of behavior and physiology. We characterize the clock of the adrenal, an important endocrine gland that synchronizes physiological and metabolic rhythms. Clock gene expression was detected in the outer adrenal cortex prefiguring a role of the clock in regulating gluco- and mineral corticoid biogenesis. In
Per2/Cry1 double mutant mice, which lack a circadian clock, hypothalamus/pituitary/adrenal axis regulation was defective. Organ culture and tissue transplantation suggest that the adrenal pacemaker gates glucocorticoid production in response to adrenocorticotropin (ACTH). In vivo the adrenal circadian clock can be entrained by light. Transcriptome profiling identified rhythmically expressed genes located at diverse nodes of steroid biogenesis that may mediate gating of the ACTH response by the adrenal clock.</description><identifier>ISSN: 1550-4131</identifier><identifier>EISSN: 1932-7420</identifier><identifier>DOI: 10.1016/j.cmet.2006.07.002</identifier><identifier>PMID: 16890544</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Adrenal Cortex - chemistry ; Adrenal Cortex - metabolism ; Adrenal Cortex Hormones - analysis ; Adrenal Cortex Hormones - metabolism ; Animals ; Biological Clocks - physiology ; Cell Cycle Proteins - genetics ; Cell Cycle Proteins - metabolism ; Cells, Cultured ; Circadian Rhythm - physiology ; Cryptochromes ; DEVBIO ; Flavoproteins - genetics ; Flavoproteins - metabolism ; Male ; Mice ; Mice, Inbred C57BL ; Nuclear Proteins - genetics ; Nuclear Proteins - metabolism ; Organ Culture Techniques ; Period Circadian Proteins ; Signal Transduction ; Suprachiasmatic Nucleus - metabolism ; SYSBIO ; Transcription Factors - genetics ; Transcription Factors - metabolism</subject><ispartof>Cell metabolism, 2006-08, Vol.4 (2), p.163-173</ispartof><rights>2006 Elsevier Inc.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c464t-77ade22641f18c6b94123160fabd7e78ffa699f9289173f8a8f0e887ea4aee553</citedby><cites>FETCH-LOGICAL-c464t-77ade22641f18c6b94123160fabd7e78ffa699f9289173f8a8f0e887ea4aee553</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S1550413106002415$$EHTML$$P50$$Gelsevier$$Hfree_for_read</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16890544$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Oster, Henrik</creatorcontrib><creatorcontrib>Damerow, Sebastian</creatorcontrib><creatorcontrib>Kiessling, Silke</creatorcontrib><creatorcontrib>Jakubcakova, Vladimira</creatorcontrib><creatorcontrib>Abraham, Diya</creatorcontrib><creatorcontrib>Tian, Jiong</creatorcontrib><creatorcontrib>Hoffmann, Matthias W.</creatorcontrib><creatorcontrib>Eichele, Gregor</creatorcontrib><title>The circadian rhythm of glucocorticoids is regulated by a gating mechanism residing in the adrenal cortical clock</title><title>Cell metabolism</title><addtitle>Cell Metab</addtitle><description>In mammals, the master clock of the
suprachiasmatic nuclei (SCN) and subordinate clocks found throughout the body coordinate circadian rhythms of behavior and physiology. We characterize the clock of the adrenal, an important endocrine gland that synchronizes physiological and metabolic rhythms. Clock gene expression was detected in the outer adrenal cortex prefiguring a role of the clock in regulating gluco- and mineral corticoid biogenesis. In
Per2/Cry1 double mutant mice, which lack a circadian clock, hypothalamus/pituitary/adrenal axis regulation was defective. Organ culture and tissue transplantation suggest that the adrenal pacemaker gates glucocorticoid production in response to adrenocorticotropin (ACTH). In vivo the adrenal circadian clock can be entrained by light. Transcriptome profiling identified rhythmically expressed genes located at diverse nodes of steroid biogenesis that may mediate gating of the ACTH response by the adrenal clock.</description><subject>Adrenal Cortex - chemistry</subject><subject>Adrenal Cortex - metabolism</subject><subject>Adrenal Cortex Hormones - analysis</subject><subject>Adrenal Cortex Hormones - metabolism</subject><subject>Animals</subject><subject>Biological Clocks - physiology</subject><subject>Cell Cycle Proteins - genetics</subject><subject>Cell Cycle Proteins - metabolism</subject><subject>Cells, Cultured</subject><subject>Circadian Rhythm - physiology</subject><subject>Cryptochromes</subject><subject>DEVBIO</subject><subject>Flavoproteins - genetics</subject><subject>Flavoproteins - metabolism</subject><subject>Male</subject><subject>Mice</subject><subject>Mice, Inbred C57BL</subject><subject>Nuclear Proteins - genetics</subject><subject>Nuclear Proteins - metabolism</subject><subject>Organ Culture Techniques</subject><subject>Period Circadian Proteins</subject><subject>Signal Transduction</subject><subject>Suprachiasmatic Nucleus - metabolism</subject><subject>SYSBIO</subject><subject>Transcription Factors - genetics</subject><subject>Transcription Factors - metabolism</subject><issn>1550-4131</issn><issn>1932-7420</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2006</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kE1r3DAQhkVJaT7aP9BD0Ck3u_qyJEMvJaRtYKGX9Cy00mhXG9tKJDmw_742u5BbTzPMvPPAPAh9paSlhMpvh9aNUFtGiGyJaglhH9AV7TlrlGDkYum7jjSCcnqJrks5EMIl7_kndEml7kknxBV6fdoDdjE766OdcN4f637EKeDdMLvkUq7RpegLjgVn2M2DreDx9ogt3tkapx0ewe3tFMu47Ev06yhOuC5Y6zNMdsAnytoMyT1_Rh-DHQp8Odcb9Pfnw9P972bz59fj_Y9N44QUtVHKemBMChqodnLbC8o4lSTYrVegdAhW9n3ome6p4kFbHQhorcAKC9B1_AbdnbgvOb3OUKoZY3EwDHaCNBcjtSJSaL4E2SnociolQzAvOY42Hw0lZhVtDmYVbVbRhiiziF6Obs_0eTuCfz85m10C308BWH58i5BNcREmBz5mcNX4FP_H_wdfdZCw</recordid><startdate>20060801</startdate><enddate>20060801</enddate><creator>Oster, Henrik</creator><creator>Damerow, Sebastian</creator><creator>Kiessling, Silke</creator><creator>Jakubcakova, Vladimira</creator><creator>Abraham, Diya</creator><creator>Tian, Jiong</creator><creator>Hoffmann, Matthias W.</creator><creator>Eichele, Gregor</creator><general>Elsevier Inc</general><scope>6I.</scope><scope>AAFTH</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20060801</creationdate><title>The circadian rhythm of glucocorticoids is regulated by a gating mechanism residing in the adrenal cortical clock</title><author>Oster, Henrik ; Damerow, Sebastian ; Kiessling, Silke ; Jakubcakova, Vladimira ; Abraham, Diya ; Tian, Jiong ; Hoffmann, Matthias W. ; Eichele, Gregor</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c464t-77ade22641f18c6b94123160fabd7e78ffa699f9289173f8a8f0e887ea4aee553</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2006</creationdate><topic>Adrenal Cortex - chemistry</topic><topic>Adrenal Cortex - metabolism</topic><topic>Adrenal Cortex Hormones - analysis</topic><topic>Adrenal Cortex Hormones - metabolism</topic><topic>Animals</topic><topic>Biological Clocks - physiology</topic><topic>Cell Cycle Proteins - genetics</topic><topic>Cell Cycle Proteins - metabolism</topic><topic>Cells, Cultured</topic><topic>Circadian Rhythm - physiology</topic><topic>Cryptochromes</topic><topic>DEVBIO</topic><topic>Flavoproteins - genetics</topic><topic>Flavoproteins - metabolism</topic><topic>Male</topic><topic>Mice</topic><topic>Mice, Inbred C57BL</topic><topic>Nuclear Proteins - genetics</topic><topic>Nuclear Proteins - metabolism</topic><topic>Organ Culture Techniques</topic><topic>Period Circadian Proteins</topic><topic>Signal Transduction</topic><topic>Suprachiasmatic Nucleus - metabolism</topic><topic>SYSBIO</topic><topic>Transcription Factors - genetics</topic><topic>Transcription Factors - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Oster, Henrik</creatorcontrib><creatorcontrib>Damerow, Sebastian</creatorcontrib><creatorcontrib>Kiessling, Silke</creatorcontrib><creatorcontrib>Jakubcakova, Vladimira</creatorcontrib><creatorcontrib>Abraham, Diya</creatorcontrib><creatorcontrib>Tian, Jiong</creatorcontrib><creatorcontrib>Hoffmann, Matthias W.</creatorcontrib><creatorcontrib>Eichele, Gregor</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Cell metabolism</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Oster, Henrik</au><au>Damerow, Sebastian</au><au>Kiessling, Silke</au><au>Jakubcakova, Vladimira</au><au>Abraham, Diya</au><au>Tian, Jiong</au><au>Hoffmann, Matthias W.</au><au>Eichele, Gregor</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The circadian rhythm of glucocorticoids is regulated by a gating mechanism residing in the adrenal cortical clock</atitle><jtitle>Cell metabolism</jtitle><addtitle>Cell Metab</addtitle><date>2006-08-01</date><risdate>2006</risdate><volume>4</volume><issue>2</issue><spage>163</spage><epage>173</epage><pages>163-173</pages><issn>1550-4131</issn><eissn>1932-7420</eissn><abstract>In mammals, the master clock of the
suprachiasmatic nuclei (SCN) and subordinate clocks found throughout the body coordinate circadian rhythms of behavior and physiology. We characterize the clock of the adrenal, an important endocrine gland that synchronizes physiological and metabolic rhythms. Clock gene expression was detected in the outer adrenal cortex prefiguring a role of the clock in regulating gluco- and mineral corticoid biogenesis. In
Per2/Cry1 double mutant mice, which lack a circadian clock, hypothalamus/pituitary/adrenal axis regulation was defective. Organ culture and tissue transplantation suggest that the adrenal pacemaker gates glucocorticoid production in response to adrenocorticotropin (ACTH). In vivo the adrenal circadian clock can be entrained by light. Transcriptome profiling identified rhythmically expressed genes located at diverse nodes of steroid biogenesis that may mediate gating of the ACTH response by the adrenal clock.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>16890544</pmid><doi>10.1016/j.cmet.2006.07.002</doi><tpages>11</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1550-4131 |
| ispartof | Cell metabolism, 2006-08, Vol.4 (2), p.163-173 |
| issn | 1550-4131 1932-7420 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_68706483 |
| source | MEDLINE; Cell Press Free Archives; Elsevier ScienceDirect Journals; EZB-FREE-00999 freely available EZB journals |
| subjects | Adrenal Cortex - chemistry Adrenal Cortex - metabolism Adrenal Cortex Hormones - analysis Adrenal Cortex Hormones - metabolism Animals Biological Clocks - physiology Cell Cycle Proteins - genetics Cell Cycle Proteins - metabolism Cells, Cultured Circadian Rhythm - physiology Cryptochromes DEVBIO Flavoproteins - genetics Flavoproteins - metabolism Male Mice Mice, Inbred C57BL Nuclear Proteins - genetics Nuclear Proteins - metabolism Organ Culture Techniques Period Circadian Proteins Signal Transduction Suprachiasmatic Nucleus - metabolism SYSBIO Transcription Factors - genetics Transcription Factors - metabolism |
| title | The circadian rhythm of glucocorticoids is regulated by a gating mechanism residing in the adrenal cortical clock |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-05T07%3A24%3A40IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=The%20circadian%20rhythm%20of%20glucocorticoids%20is%20regulated%20by%20a%20gating%20mechanism%20residing%20in%20the%20adrenal%20cortical%20clock&rft.jtitle=Cell%20metabolism&rft.au=Oster,%20Henrik&rft.date=2006-08-01&rft.volume=4&rft.issue=2&rft.spage=163&rft.epage=173&rft.pages=163-173&rft.issn=1550-4131&rft.eissn=1932-7420&rft_id=info:doi/10.1016/j.cmet.2006.07.002&rft_dat=%3Cproquest_cross%3E68706483%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=68706483&rft_id=info:pmid/16890544&rft_els_id=S1550413106002415&rfr_iscdi=true |