Subgenual anterior cingulate activation to valenced emotional stimuli in major depression
Major depression has been associated with anomalous activation in the subgenual anterior cingulate cortex, but its response to emotional stimuli is poorly understood. The primary goal of this study was to compare levels of activation in the subgenual anterior cingulate cortex of diagnosed depressed...
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| Veröffentlicht in: | Neuroreport 2005-11, Vol.16 (16), p.1731-1734 |
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| creator | Gotlib, Ian H Sivers, Heidi Gabrieli, John D.E Whitfield-Gabrieli, Susan Goldin, Philippe Minor, Kelly L Canli, Turhan |
| description | Major depression has been associated with anomalous activation in the subgenual anterior cingulate cortex, but its response to emotional stimuli is poorly understood. The primary goal of this study was to compare levels of activation in the subgenual anterior cingulate cortex of diagnosed depressed and nondepressed participants in response to happy and sad facial expressions of affect. Whereas cognitive theories of depression predict increased activation to negative stimuli, depressed participants were found to exhibit increased activation to both types of stimuli in the subgenual anterior cingulate cortex. Importantly, the loci were in different regions of the subgenual anterior cingulate cortex, suggesting that there is functional specialization in the processing of negatively and positively valenced stimuli. |
| doi_str_mv | 10.1097/01.wnr.0000183901.70030.82 |
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The primary goal of this study was to compare levels of activation in the subgenual anterior cingulate cortex of diagnosed depressed and nondepressed participants in response to happy and sad facial expressions of affect. Whereas cognitive theories of depression predict increased activation to negative stimuli, depressed participants were found to exhibit increased activation to both types of stimuli in the subgenual anterior cingulate cortex. Importantly, the loci were in different regions of the subgenual anterior cingulate cortex, suggesting that there is functional specialization in the processing of negatively and positively valenced stimuli.</description><identifier>ISSN: 0959-4965</identifier><identifier>EISSN: 1473-558X</identifier><identifier>DOI: 10.1097/01.wnr.0000183901.70030.82</identifier><identifier>PMID: 16237317</identifier><language>eng</language><publisher>Hagerstown, MD: Lippincott Williams & Wilkins, Inc</publisher><subject>Adult ; Adult and adolescent clinical studies ; Biological and medical sciences ; Brain Mapping ; Carbamide Peroxide ; Depression ; Depressive Disorder, Major - pathology ; Depressive Disorder, Major - physiopathology ; Drug Combinations ; Emotions - physiology ; Facial Expression ; Female ; Gyrus Cinguli - blood supply ; Gyrus Cinguli - pathology ; Gyrus Cinguli - physiopathology ; Humans ; Image Processing, Computer-Assisted - methods ; Magnetic Resonance Imaging - methods ; Male ; Medical sciences ; Mood disorders ; Peroxides - blood ; Psychology. 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Psychiatry ; Urea - analogs & derivatives ; Urea - blood</subject><ispartof>Neuroreport, 2005-11, Vol.16 (16), p.1731-1734</ispartof><rights>2005 Lippincott Williams & Wilkins, Inc.</rights><rights>2005 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4232-89064f60bf564ab0836601de24a5ef979c69eef0fa96c5e18caff7e4f742244d3</citedby><cites>FETCH-LOGICAL-c4232-89064f60bf564ab0836601de24a5ef979c69eef0fa96c5e18caff7e4f742244d3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>315,781,785,27926,27927</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=17217223$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16237317$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Gotlib, Ian H</creatorcontrib><creatorcontrib>Sivers, Heidi</creatorcontrib><creatorcontrib>Gabrieli, John D.E</creatorcontrib><creatorcontrib>Whitfield-Gabrieli, Susan</creatorcontrib><creatorcontrib>Goldin, Philippe</creatorcontrib><creatorcontrib>Minor, Kelly L</creatorcontrib><creatorcontrib>Canli, Turhan</creatorcontrib><title>Subgenual anterior cingulate activation to valenced emotional stimuli in major depression</title><title>Neuroreport</title><addtitle>Neuroreport</addtitle><description>Major depression has been associated with anomalous activation in the subgenual anterior cingulate cortex, but its response to emotional stimuli is poorly understood. The primary goal of this study was to compare levels of activation in the subgenual anterior cingulate cortex of diagnosed depressed and nondepressed participants in response to happy and sad facial expressions of affect. Whereas cognitive theories of depression predict increased activation to negative stimuli, depressed participants were found to exhibit increased activation to both types of stimuli in the subgenual anterior cingulate cortex. Importantly, the loci were in different regions of the subgenual anterior cingulate cortex, suggesting that there is functional specialization in the processing of negatively and positively valenced stimuli.</description><subject>Adult</subject><subject>Adult and adolescent clinical studies</subject><subject>Biological and medical sciences</subject><subject>Brain Mapping</subject><subject>Carbamide Peroxide</subject><subject>Depression</subject><subject>Depressive Disorder, Major - pathology</subject><subject>Depressive Disorder, Major - physiopathology</subject><subject>Drug Combinations</subject><subject>Emotions - physiology</subject><subject>Facial Expression</subject><subject>Female</subject><subject>Gyrus Cinguli - blood supply</subject><subject>Gyrus Cinguli - pathology</subject><subject>Gyrus Cinguli - physiopathology</subject><subject>Humans</subject><subject>Image Processing, Computer-Assisted - methods</subject><subject>Magnetic Resonance Imaging - methods</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Mood disorders</subject><subject>Peroxides - blood</subject><subject>Psychology. Psychoanalysis. Psychiatry</subject><subject>Psychopathology. 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Psychoanalysis. Psychiatry</topic><topic>Psychopathology. Psychiatry</topic><topic>Urea - analogs & derivatives</topic><topic>Urea - blood</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Gotlib, Ian H</creatorcontrib><creatorcontrib>Sivers, Heidi</creatorcontrib><creatorcontrib>Gabrieli, John D.E</creatorcontrib><creatorcontrib>Whitfield-Gabrieli, Susan</creatorcontrib><creatorcontrib>Goldin, Philippe</creatorcontrib><creatorcontrib>Minor, Kelly L</creatorcontrib><creatorcontrib>Canli, Turhan</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Neuroreport</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Gotlib, Ian H</au><au>Sivers, Heidi</au><au>Gabrieli, John D.E</au><au>Whitfield-Gabrieli, Susan</au><au>Goldin, Philippe</au><au>Minor, Kelly L</au><au>Canli, Turhan</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Subgenual anterior cingulate activation to valenced emotional stimuli in major depression</atitle><jtitle>Neuroreport</jtitle><addtitle>Neuroreport</addtitle><date>2005-11-07</date><risdate>2005</risdate><volume>16</volume><issue>16</issue><spage>1731</spage><epage>1734</epage><pages>1731-1734</pages><issn>0959-4965</issn><eissn>1473-558X</eissn><abstract>Major depression has been associated with anomalous activation in the subgenual anterior cingulate cortex, but its response to emotional stimuli is poorly understood. 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| subjects | Adult Adult and adolescent clinical studies Biological and medical sciences Brain Mapping Carbamide Peroxide Depression Depressive Disorder, Major - pathology Depressive Disorder, Major - physiopathology Drug Combinations Emotions - physiology Facial Expression Female Gyrus Cinguli - blood supply Gyrus Cinguli - pathology Gyrus Cinguli - physiopathology Humans Image Processing, Computer-Assisted - methods Magnetic Resonance Imaging - methods Male Medical sciences Mood disorders Peroxides - blood Psychology. Psychoanalysis. Psychiatry Psychopathology. Psychiatry Urea - analogs & derivatives Urea - blood |
| title | Subgenual anterior cingulate activation to valenced emotional stimuli in major depression |
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