The Course of Uncarinic Acid E-Induced Apoptosis of HepG2 Cells from Damage to DNA and p53 Activation to Mitochondrial Release of Cytochrome c

Uncarinic acid E, an active component isolated from Gelsemium elegans BENTH, has been reported to exhibit antitumor effects, but little is known about its molecular mechanisms of action. In this study, the growth-inhibitory activity of uncarinic acid E for HepG2 cells is in time- and dose-dependent...

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Veröffentlicht in:	Biological & Pharmaceutical Bulletin 2006, Vol.29(8), pp.1639-1644
Hauptverfasser:	Zhao, Minghong, Guo, Tao, Wang, Minwei, Zhao, Qingchun, Liu, Yanxia, Sun, Xuehui, Wang, Huailiang, Hou, Yue
Format:	Artikel
Sprache:	eng
Schlagworte:	apoptosis Apoptosis - drug effects Caspases - metabolism Cell Line, Tumor Cytochromes c - metabolism DNA Damage Electrophoresis, Agar Gel Esters - pharmacology Gelsemium Gelsemium elegans HepG2 cell Humans Mitochondria - enzymology Protein Kinase C - metabolism Triterpenes - pharmacology Tumor Suppressor Protein p53 - metabolism uncarinic acid E
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