Hyperhomocysteinemia as a risk factor for ischemic stroke: An Indian scenario
Background : Hyperhomocysteinemia has been proposed as an important risk factor for ischemic stroke worldwide, but data available from the Indian subcontinent is scarce. Aim : To study homocysteine levels in patients with ischemic stroke and compare it with age- and sex-matched controls. Settings an...
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| Veröffentlicht in: | Neurology India 2005-09, Vol.53 (3), p.297-301; discussion 301-2 |
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| creator | Modi M, Prabhakar S, Majumdar S, Khullar M, Lal V, Das CP |
| description | Background : Hyperhomocysteinemia has been proposed as an important
risk factor for ischemic stroke worldwide, but data available from the
Indian subcontinent is scarce. Aim : To study homocysteine levels in
patients with ischemic stroke and compare it with age- and sex-matched
controls. Settings and Design: Case-control prospective study.
Materials and Methods: Fifty-seven patients with ischemic stroke and 30
controls were recruited for the study. They were subdivided into two
subgroups (40 years of age) and plasma fasting
total homocysteine (tHcy) levels were measured. Statistical analysis
used: Student′s ′t′ test and chi-square test.
Results: The tHcy were significantly high in patients with stroke,
compared to controls (9.91 ± 2.25 vs 8.00 ± 2.74 mmol/l; P
< 0.001). Significantly high levels were seen in both male patients
compared to controls (10.24 ± 2.34 vs 8.45 ± 2.72
μmol/l; P = 0.01) and female patients compared to controls (9.08
± 1.81 vs 6.79 ± 2.60 μmol/l; P = 0.04). The tHcy
levels were significantly high in patients with hypertension compared
to normotensive patients (10.96 vs 9.49 μmol/l; P = 0.01) and
smokers compared to nonsmokers (11.17 vs 9.33 μol/l; P = 0.01).
Conclusions : Hyperhomo-cysteinemia emerged as an important
independent risk factor for ischemic stroke. A strong positive
correlation was also observed between hypertension, smoking, and
high-tHcy levels in the present study. |
| doi_str_mv | 10.4103/0028-3886.16927 |
| format | Article |
| fullrecord | <record><control><sourceid>gale_proqu</sourceid><recordid>TN_cdi_proquest_miscellaneous_68705630</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A137849465</galeid><sourcerecordid>A137849465</sourcerecordid><originalsourceid>FETCH-LOGICAL-b479t-1e501abaa46d6079820c95d33d19153ca080b2d8966c3f71b48bb1a196a1b4443</originalsourceid><addsrcrecordid>eNptkU1vGyEQhlHUKHaTnHurUA-5rc3XstCbFTVNJFe5tGc0y7IJ8S64sD743xfXbiJVEaCBmWfgFS9CnyhZCEr4khCmKq6UXFCpWXOG5lRrVQnC2Ac0f63O0MecX8qRc8ou0IxKxkmj5Rz9uN9vXXqOY7T7PDkf3OgBQ8aAk88b3IOdYsJ9WT7b51K1OE8pbtxXvAr4IXQeAs7WBUg-XqHzHobsrk_xEv26-_bz9r5aP35_uF2tq1Y0eqqoqwmFFkDIThYdihGr647zjmpacwtEkZZ1Sktped_QVqi2pUC1hLIXgl-im-O92xR_71yezFjUuWGA4OIuG6kaUktOCvjlP_Al7lIo2gzjUsumkbxA1RF6gsEZH_o4JbBPLrgEQwyu9yW9orxRQgtZF37xDl9Gd_iedxuWxwabYs7J9Wab_AhpbygxBx_NwSlzcMr89bF0fD7p3rWj6974k3FvGlofh-LaK2GTB_MvGXyZpC4v8D8kM6Zk</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>236967763</pqid></control><display><type>article</type><title>Hyperhomocysteinemia as a risk factor for ischemic stroke: An Indian scenario</title><source>MEDLINE</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>Bioline International</source><creator>Modi M, Prabhakar S, Majumdar S, Khullar M, Lal V, Das CP</creator><creatorcontrib>Modi M, Prabhakar S, Majumdar S, Khullar M, Lal V, Das CP</creatorcontrib><description>Background : Hyperhomocysteinemia has been proposed as an important
risk factor for ischemic stroke worldwide, but data available from the
Indian subcontinent is scarce. Aim : To study homocysteine levels in
patients with ischemic stroke and compare it with age- and sex-matched
controls. Settings and Design: Case-control prospective study.
Materials and Methods: Fifty-seven patients with ischemic stroke and 30
controls were recruited for the study. They were subdivided into two
subgroups (<40 years and >40 years of age) and plasma fasting
total homocysteine (tHcy) levels were measured. Statistical analysis
used: Student′s ′t′ test and chi-square test.
Results: The tHcy were significantly high in patients with stroke,
compared to controls (9.91 ± 2.25 vs 8.00 ± 2.74 mmol/l; P
< 0.001). Significantly high levels were seen in both male patients
compared to controls (10.24 ± 2.34 vs 8.45 ± 2.72
μmol/l; P = 0.01) and female patients compared to controls (9.08
± 1.81 vs 6.79 ± 2.60 μmol/l; P = 0.04). The tHcy
levels were significantly high in patients with hypertension compared
to normotensive patients (10.96 vs 9.49 μmol/l; P = 0.01) and
smokers compared to nonsmokers (11.17 vs 9.33 μol/l; P = 0.01).
Conclusions : Hyperhomo-cysteinemia emerged as an important
independent risk factor for ischemic stroke. A strong positive
correlation was also observed between hypertension, smoking, and
high-tHcy levels in the present study.</description><identifier>ISSN: 0028-3886</identifier><identifier>EISSN: 1998-4022</identifier><identifier>DOI: 10.4103/0028-3886.16927</identifier><identifier>PMID: 16230796</identifier><language>eng</language><publisher>India: Medknow Publications on behalf of the Neurological Society of India</publisher><subject>Adult ; Brain Ischemia - epidemiology ; Case-Control Studies ; Case-control study ; Female ; Health aspects ; Homocysteine ; Humans ; Hyperhomocysteinemia - complications ; India - epidemiology ; Ischemia ; ischemic stroke ; Male ; Middle Aged ; Risk Factors ; Stroke - epidemiology</subject><ispartof>Neurology India, 2005-09, Vol.53 (3), p.297-301; discussion 301-2</ispartof><rights>Copyright 2005 Neurology India.</rights><rights>COPYRIGHT 2005 Medknow Publications and Media Pvt. Ltd.</rights><rights>Copyright Medknow Publications Jul-Sep 2005</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-b479t-1e501abaa46d6079820c95d33d19153ca080b2d8966c3f71b48bb1a196a1b4443</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925,79298</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16230796$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Modi M, Prabhakar S, Majumdar S, Khullar M, Lal V, Das CP</creatorcontrib><title>Hyperhomocysteinemia as a risk factor for ischemic stroke: An Indian scenario</title><title>Neurology India</title><addtitle>Neurol India</addtitle><description>Background : Hyperhomocysteinemia has been proposed as an important
risk factor for ischemic stroke worldwide, but data available from the
Indian subcontinent is scarce. Aim : To study homocysteine levels in
patients with ischemic stroke and compare it with age- and sex-matched
controls. Settings and Design: Case-control prospective study.
Materials and Methods: Fifty-seven patients with ischemic stroke and 30
controls were recruited for the study. They were subdivided into two
subgroups (<40 years and >40 years of age) and plasma fasting
total homocysteine (tHcy) levels were measured. Statistical analysis
used: Student′s ′t′ test and chi-square test.
Results: The tHcy were significantly high in patients with stroke,
compared to controls (9.91 ± 2.25 vs 8.00 ± 2.74 mmol/l; P
< 0.001). Significantly high levels were seen in both male patients
compared to controls (10.24 ± 2.34 vs 8.45 ± 2.72
μmol/l; P = 0.01) and female patients compared to controls (9.08
± 1.81 vs 6.79 ± 2.60 μmol/l; P = 0.04). The tHcy
levels were significantly high in patients with hypertension compared
to normotensive patients (10.96 vs 9.49 μmol/l; P = 0.01) and
smokers compared to nonsmokers (11.17 vs 9.33 μol/l; P = 0.01).
Conclusions : Hyperhomo-cysteinemia emerged as an important
independent risk factor for ischemic stroke. A strong positive
correlation was also observed between hypertension, smoking, and
high-tHcy levels in the present study.</description><subject>Adult</subject><subject>Brain Ischemia - epidemiology</subject><subject>Case-Control Studies</subject><subject>Case-control study</subject><subject>Female</subject><subject>Health aspects</subject><subject>Homocysteine</subject><subject>Humans</subject><subject>Hyperhomocysteinemia - complications</subject><subject>India - epidemiology</subject><subject>Ischemia</subject><subject>ischemic stroke</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Risk Factors</subject><subject>Stroke - epidemiology</subject><issn>0028-3886</issn><issn>1998-4022</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><sourceid>RBI</sourceid><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNptkU1vGyEQhlHUKHaTnHurUA-5rc3XstCbFTVNJFe5tGc0y7IJ8S64sD743xfXbiJVEaCBmWfgFS9CnyhZCEr4khCmKq6UXFCpWXOG5lRrVQnC2Ac0f63O0MecX8qRc8ou0IxKxkmj5Rz9uN9vXXqOY7T7PDkf3OgBQ8aAk88b3IOdYsJ9WT7b51K1OE8pbtxXvAr4IXQeAs7WBUg-XqHzHobsrk_xEv26-_bz9r5aP35_uF2tq1Y0eqqoqwmFFkDIThYdihGr647zjmpacwtEkZZ1Sktped_QVqi2pUC1hLIXgl-im-O92xR_71yezFjUuWGA4OIuG6kaUktOCvjlP_Al7lIo2gzjUsumkbxA1RF6gsEZH_o4JbBPLrgEQwyu9yW9orxRQgtZF37xDl9Gd_iedxuWxwabYs7J9Wab_AhpbygxBx_NwSlzcMr89bF0fD7p3rWj6974k3FvGlofh-LaK2GTB_MvGXyZpC4v8D8kM6Zk</recordid><startdate>20050901</startdate><enddate>20050901</enddate><creator>Modi M, Prabhakar S, Majumdar S, Khullar M, Lal V, Das CP</creator><general>Medknow Publications on behalf of the Neurological Society of India</general><general>Medknow Publications and Media Pvt. Ltd</general><general>Medknow Publications & Media Pvt. Ltd</general><scope>RBI</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>M2O</scope><scope>MBDVC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>Q9U</scope><scope>7X8</scope></search><sort><creationdate>20050901</creationdate><title>Hyperhomocysteinemia as a risk factor for ischemic stroke: An Indian scenario</title><author>Modi M, Prabhakar S, Majumdar S, Khullar M, Lal V, Das CP</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-b479t-1e501abaa46d6079820c95d33d19153ca080b2d8966c3f71b48bb1a196a1b4443</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>Adult</topic><topic>Brain Ischemia - epidemiology</topic><topic>Case-Control Studies</topic><topic>Case-control study</topic><topic>Female</topic><topic>Health aspects</topic><topic>Homocysteine</topic><topic>Humans</topic><topic>Hyperhomocysteinemia - complications</topic><topic>India - epidemiology</topic><topic>Ischemia</topic><topic>ischemic stroke</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Risk Factors</topic><topic>Stroke - epidemiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Modi M, Prabhakar S, Majumdar S, Khullar M, Lal V, Das CP</creatorcontrib><collection>Bioline International</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Research Library</collection><collection>Research Library (Corporate)</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><jtitle>Neurology India</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Modi M, Prabhakar S, Majumdar S, Khullar M, Lal V, Das CP</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Hyperhomocysteinemia as a risk factor for ischemic stroke: An Indian scenario</atitle><jtitle>Neurology India</jtitle><addtitle>Neurol India</addtitle><date>2005-09-01</date><risdate>2005</risdate><volume>53</volume><issue>3</issue><spage>297</spage><epage>301; discussion 301-2</epage><pages>297-301; discussion 301-2</pages><issn>0028-3886</issn><eissn>1998-4022</eissn><abstract>Background : Hyperhomocysteinemia has been proposed as an important
risk factor for ischemic stroke worldwide, but data available from the
Indian subcontinent is scarce. Aim : To study homocysteine levels in
patients with ischemic stroke and compare it with age- and sex-matched
controls. Settings and Design: Case-control prospective study.
Materials and Methods: Fifty-seven patients with ischemic stroke and 30
controls were recruited for the study. They were subdivided into two
subgroups (<40 years and >40 years of age) and plasma fasting
total homocysteine (tHcy) levels were measured. Statistical analysis
used: Student′s ′t′ test and chi-square test.
Results: The tHcy were significantly high in patients with stroke,
compared to controls (9.91 ± 2.25 vs 8.00 ± 2.74 mmol/l; P
< 0.001). Significantly high levels were seen in both male patients
compared to controls (10.24 ± 2.34 vs 8.45 ± 2.72
μmol/l; P = 0.01) and female patients compared to controls (9.08
± 1.81 vs 6.79 ± 2.60 μmol/l; P = 0.04). The tHcy
levels were significantly high in patients with hypertension compared
to normotensive patients (10.96 vs 9.49 μmol/l; P = 0.01) and
smokers compared to nonsmokers (11.17 vs 9.33 μol/l; P = 0.01).
Conclusions : Hyperhomo-cysteinemia emerged as an important
independent risk factor for ischemic stroke. A strong positive
correlation was also observed between hypertension, smoking, and
high-tHcy levels in the present study.</abstract><cop>India</cop><pub>Medknow Publications on behalf of the Neurological Society of India</pub><pmid>16230796</pmid><doi>10.4103/0028-3886.16927</doi><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0028-3886 |
| ispartof | Neurology India, 2005-09, Vol.53 (3), p.297-301; discussion 301-2 |
| issn | 0028-3886 1998-4022 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_68705630 |
| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Bioline International |
| subjects | Adult Brain Ischemia - epidemiology Case-Control Studies Case-control study Female Health aspects Homocysteine Humans Hyperhomocysteinemia - complications India - epidemiology Ischemia ischemic stroke Male Middle Aged Risk Factors Stroke - epidemiology |
| title | Hyperhomocysteinemia as a risk factor for ischemic stroke: An Indian scenario |
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