Asymmetric Total Synthesis of Fredericamycin A: An Intramolecular Cycloaddition Pathway

The asymmetric total synthesis of the potent antitumor antibiotic fredericamycin A ((S)‐1) was achieved by the intramolecular [4+2] cycloaddition of the silylene‐protected styrene derivative (S)‐7 followed by the aromatic Pummerer‐type reaction of the sulfoxide (S)‐5. Although we had already succeed...

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