The Association of Third-Generation Cephalosporin Use and Invasive Candidiasis in Extremely Low Birth-Weight Infants

Previous studies have shown that incidence of invasive candidiasis varies substantially among centers, and previous use of broad-spectrum antibiotics is a risk factor for candidiasis in extremely low birth-weight infants. Differences in center practices, such as antibiotic strategies and the effects...

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Veröffentlicht in:Pediatrics (Evanston) 2006-08, Vol.118 (2), p.717-722
Hauptverfasser: Cotten, C. Michael, McDonald, Scott, Stoll, Barbara, Goldberg, Ronald N, Poole, Kenneth, Benjamin, Daniel K., Jr, on behalf of National Institute for Child Health and Human Development Neonatal Research Network
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container_issue 2
container_start_page 717
container_title Pediatrics (Evanston)
container_volume 118
creator Cotten, C. Michael
McDonald, Scott
Stoll, Barbara
Goldberg, Ronald N
Poole, Kenneth
Benjamin, Daniel K., Jr
on behalf of National Institute for Child Health and Human Development Neonatal Research Network
description Previous studies have shown that incidence of invasive candidiasis varies substantially among centers, and previous use of broad-spectrum antibiotics is a risk factor for candidiasis in extremely low birth-weight infants. Differences in center practices, such as antibiotic strategies and the effects of these strategies on center incidence of candidiasis, are not reflected in assessments of an individual's risk of candidiasis. We evaluated the relationship between empirical antibiotic practices for extremely low birth-weight infants and center incidence of candidiasis. We studied a cohort of extremely low birth-weight infants who survived > or = 72 hours and were admitted to 1 of 12 tertiary centers between 1998 and 2001. Multivariable logistic regression was used to validate previous broad-spectrum antibiotics use as a risk factor for subsequent candidiasis in individual infants. We calculated correlation coefficients to assess the relationship between center incidence of candidiasis with antibiotic practice patterns. There were 3702 infants from 12 centers included, and 284 (7.7%) developed invasive candidiasis. Broad-spectrum antibiotics use was associated with candidiasis for individual infants. Center candidiasis incidence ranged from 2.4% to 20.4%. Center incidence of candidiasis was correlated with average broad-spectrum antibiotics use per infant and average use of broad-spectrum antibiotics with negative cultures per infant. Center incidences of invasive candidiasis differ substantially, and antibiotic practice differences are possible contributors to center variation in candidiasis risk.
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Michael ; McDonald, Scott ; Stoll, Barbara ; Goldberg, Ronald N ; Poole, Kenneth ; Benjamin, Daniel K., Jr ; on behalf of National Institute for Child Health and Human Development Neonatal Research Network</creator><creatorcontrib>Cotten, C. Michael ; McDonald, Scott ; Stoll, Barbara ; Goldberg, Ronald N ; Poole, Kenneth ; Benjamin, Daniel K., Jr ; on behalf of National Institute for Child Health and Human Development Neonatal Research Network ; National Institute for Child Health and Human Development Neonatal Research Network ; on behalf of the National Institute for Child Health and Human Development Neonatal Research Network</creatorcontrib><description>Previous studies have shown that incidence of invasive candidiasis varies substantially among centers, and previous use of broad-spectrum antibiotics is a risk factor for candidiasis in extremely low birth-weight infants. Differences in center practices, such as antibiotic strategies and the effects of these strategies on center incidence of candidiasis, are not reflected in assessments of an individual's risk of candidiasis. We evaluated the relationship between empirical antibiotic practices for extremely low birth-weight infants and center incidence of candidiasis. We studied a cohort of extremely low birth-weight infants who survived &gt; or = 72 hours and were admitted to 1 of 12 tertiary centers between 1998 and 2001. Multivariable logistic regression was used to validate previous broad-spectrum antibiotics use as a risk factor for subsequent candidiasis in individual infants. We calculated correlation coefficients to assess the relationship between center incidence of candidiasis with antibiotic practice patterns. There were 3702 infants from 12 centers included, and 284 (7.7%) developed invasive candidiasis. Broad-spectrum antibiotics use was associated with candidiasis for individual infants. Center candidiasis incidence ranged from 2.4% to 20.4%. Center incidence of candidiasis was correlated with average broad-spectrum antibiotics use per infant and average use of broad-spectrum antibiotics with negative cultures per infant. Center incidences of invasive candidiasis differ substantially, and antibiotic practice differences are possible contributors to center variation in candidiasis risk.</description><identifier>ISSN: 0031-4005</identifier><identifier>EISSN: 1098-4275</identifier><identifier>DOI: 10.1542/peds.2005-2677</identifier><identifier>PMID: 16882828</identifier><identifier>CODEN: PEDIAU</identifier><language>eng</language><publisher>Elk Grove Village, IL: Am Acad Pediatrics</publisher><subject>Antibiotics ; Bacterial diseases ; Bacterial sepsis ; Biological and medical sciences ; Birth weight ; Blood - microbiology ; Blood diseases ; Body fluids ; Candidiasis ; Candidiasis - epidemiology ; Candidiasis - etiology ; Carbapenems - therapeutic use ; Catheterization, Central Venous ; Central Nervous System Fungal Infections - epidemiology ; Central Nervous System Fungal Infections - etiology ; Central Nervous System Fungal Infections - microbiology ; Cephaloridine ; Cephalosporins ; Cephalosporins - classification ; Cephalosporins - therapeutic use ; Cerebrospinal Fluid - microbiology ; Comorbidity ; Complications and side effects ; Cross Infection - epidemiology ; Cross Infection - etiology ; Development and progression ; Diseases of mother, fetus and pregnancy ; Enterocolitis, Necrotizing - epidemiology ; Fungemia - epidemiology ; Fungemia - etiology ; Fungemia - microbiology ; General aspects ; Gram-Negative Bacterial Infections - drug therapy ; Gram-Negative Bacterial Infections - epidemiology ; Gynecology. Andrology. Obstetrics ; Health aspects ; Human bacterial diseases ; Humans ; Infant, Newborn ; Infant, Premature ; Infant, Premature, Diseases - epidemiology ; Infant, Premature, Diseases - etiology ; Infant, Very Low Birth Weight ; Infants (Premature) ; Infectious diseases ; Medical sciences ; Medical treatment ; Mortality ; Moxalactam ; Pediatrics ; Pregnancy. Fetus. Placenta ; Premature infants ; Prospective Studies ; Registries ; Risk Factors ; Studies ; Superinfection - epidemiology ; Superinfection - etiology</subject><ispartof>Pediatrics (Evanston), 2006-08, Vol.118 (2), p.717-722</ispartof><rights>2006 INIST-CNRS</rights><rights>COPYRIGHT 2006 American Academy of Pediatrics</rights><rights>Copyright American Academy of Pediatrics Aug 2006</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c604t-d1d720a51b81160bf5e1b632412eb5d8fedada76dc5c8f99ec2be46fbc9b40613</citedby><cites>FETCH-LOGICAL-c604t-d1d720a51b81160bf5e1b632412eb5d8fedada76dc5c8f99ec2be46fbc9b40613</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&amp;idt=18009167$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16882828$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Cotten, C. Michael</creatorcontrib><creatorcontrib>McDonald, Scott</creatorcontrib><creatorcontrib>Stoll, Barbara</creatorcontrib><creatorcontrib>Goldberg, Ronald N</creatorcontrib><creatorcontrib>Poole, Kenneth</creatorcontrib><creatorcontrib>Benjamin, Daniel K., Jr</creatorcontrib><creatorcontrib>on behalf of National Institute for Child Health and Human Development Neonatal Research Network</creatorcontrib><creatorcontrib>National Institute for Child Health and Human Development Neonatal Research Network</creatorcontrib><creatorcontrib>on behalf of the National Institute for Child Health and Human Development Neonatal Research Network</creatorcontrib><title>The Association of Third-Generation Cephalosporin Use and Invasive Candidiasis in Extremely Low Birth-Weight Infants</title><title>Pediatrics (Evanston)</title><addtitle>Pediatrics</addtitle><description>Previous studies have shown that incidence of invasive candidiasis varies substantially among centers, and previous use of broad-spectrum antibiotics is a risk factor for candidiasis in extremely low birth-weight infants. 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Center candidiasis incidence ranged from 2.4% to 20.4%. Center incidence of candidiasis was correlated with average broad-spectrum antibiotics use per infant and average use of broad-spectrum antibiotics with negative cultures per infant. 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Placenta</subject><subject>Premature infants</subject><subject>Prospective Studies</subject><subject>Registries</subject><subject>Risk Factors</subject><subject>Studies</subject><subject>Superinfection - epidemiology</subject><subject>Superinfection - etiology</subject><issn>0031-4005</issn><issn>1098-4275</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2006</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNptkk1rGzEQhpfS0rhprz2WpdBCD-tKWkmrPTomdQOGXBx6FFpp1quwllxJzse_r1wb3BSjgzQzz6sZhrcoPmI0xYyS71swcUoQYhXhTfOqmGDUioqShr0uJgjVuKK5eFG8i_EeIURZQ94WF5gLQfKZFGk1QDmL0WurkvWu9H25Gmww1QIchENuDttBjT5ufbCuvItQKmfKG_egon2Acp4ja2wOYpnr108pwAbG53LpH8srG9JQ_QK7HlKW9Mql-L5406sxwofjfVnc_bhezX9Wy9vFzXy2rDRHNFUGm4YgxXAnMOao6xngjteEYgIdM6IHo4xquNFMi75tQZMOKO873XYUcVxfFl8P_26D_72DmOTGRg3jqBz4XZRcNKjmtM7g5__Ae78LLs8mCRE15xQ3GaoO0FqNIK3rfQpKr_-uafQOepvTM8w4oy1raeanZ_h8DGysPiv49kKQmQRPaa12MUqxWL5kq3Os9uMIa5B5jfPbs8Po4GMM0MttsBsVniVGcu8kuXeS3DtJ7p2UBZ-OK9l1GzAn_GidDHw5AipqNfZBOW3jiRMItZg3p85DtsCjDbDvlM0WrI7_PDEWksgm7_kP7rrgTQ</recordid><startdate>20060801</startdate><enddate>20060801</enddate><creator>Cotten, C. Michael</creator><creator>McDonald, Scott</creator><creator>Stoll, Barbara</creator><creator>Goldberg, Ronald N</creator><creator>Poole, Kenneth</creator><creator>Benjamin, Daniel K., Jr</creator><creator>on behalf of National Institute for Child Health and Human Development Neonatal Research Network</creator><general>Am Acad Pediatrics</general><general>American Academy of Pediatrics</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>8GL</scope><scope>7TS</scope><scope>7U9</scope><scope>H94</scope><scope>K9.</scope><scope>M7N</scope><scope>NAPCQ</scope><scope>U9A</scope><scope>7X8</scope></search><sort><creationdate>20060801</creationdate><title>The Association of Third-Generation Cephalosporin Use and Invasive Candidiasis in Extremely Low Birth-Weight Infants</title><author>Cotten, C. 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Andrology. Obstetrics</topic><topic>Health aspects</topic><topic>Human bacterial diseases</topic><topic>Humans</topic><topic>Infant, Newborn</topic><topic>Infant, Premature</topic><topic>Infant, Premature, Diseases - epidemiology</topic><topic>Infant, Premature, Diseases - etiology</topic><topic>Infant, Very Low Birth Weight</topic><topic>Infants (Premature)</topic><topic>Infectious diseases</topic><topic>Medical sciences</topic><topic>Medical treatment</topic><topic>Mortality</topic><topic>Moxalactam</topic><topic>Pediatrics</topic><topic>Pregnancy. Fetus. Placenta</topic><topic>Premature infants</topic><topic>Prospective Studies</topic><topic>Registries</topic><topic>Risk Factors</topic><topic>Studies</topic><topic>Superinfection - epidemiology</topic><topic>Superinfection - etiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Cotten, C. Michael</creatorcontrib><creatorcontrib>McDonald, Scott</creatorcontrib><creatorcontrib>Stoll, Barbara</creatorcontrib><creatorcontrib>Goldberg, Ronald N</creatorcontrib><creatorcontrib>Poole, Kenneth</creatorcontrib><creatorcontrib>Benjamin, Daniel K., Jr</creatorcontrib><creatorcontrib>on behalf of National Institute for Child Health and Human Development Neonatal Research Network</creatorcontrib><creatorcontrib>National Institute for Child Health and Human Development Neonatal Research Network</creatorcontrib><creatorcontrib>on behalf of the National Institute for Child Health and Human Development Neonatal Research Network</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Gale In Context: High School</collection><collection>Physical Education Index</collection><collection>Virology and AIDS Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health &amp; Medical Complete (Alumni)</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Nursing &amp; Allied Health Premium</collection><collection>MEDLINE - Academic</collection><jtitle>Pediatrics (Evanston)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Cotten, C. 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Differences in center practices, such as antibiotic strategies and the effects of these strategies on center incidence of candidiasis, are not reflected in assessments of an individual's risk of candidiasis. We evaluated the relationship between empirical antibiotic practices for extremely low birth-weight infants and center incidence of candidiasis. We studied a cohort of extremely low birth-weight infants who survived &gt; or = 72 hours and were admitted to 1 of 12 tertiary centers between 1998 and 2001. Multivariable logistic regression was used to validate previous broad-spectrum antibiotics use as a risk factor for subsequent candidiasis in individual infants. We calculated correlation coefficients to assess the relationship between center incidence of candidiasis with antibiotic practice patterns. There were 3702 infants from 12 centers included, and 284 (7.7%) developed invasive candidiasis. Broad-spectrum antibiotics use was associated with candidiasis for individual infants. 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subjects Antibiotics
Bacterial diseases
Bacterial sepsis
Biological and medical sciences
Birth weight
Blood - microbiology
Blood diseases
Body fluids
Candidiasis
Candidiasis - epidemiology
Candidiasis - etiology
Carbapenems - therapeutic use
Catheterization, Central Venous
Central Nervous System Fungal Infections - epidemiology
Central Nervous System Fungal Infections - etiology
Central Nervous System Fungal Infections - microbiology
Cephaloridine
Cephalosporins
Cephalosporins - classification
Cephalosporins - therapeutic use
Cerebrospinal Fluid - microbiology
Comorbidity
Complications and side effects
Cross Infection - epidemiology
Cross Infection - etiology
Development and progression
Diseases of mother, fetus and pregnancy
Enterocolitis, Necrotizing - epidemiology
Fungemia - epidemiology
Fungemia - etiology
Fungemia - microbiology
General aspects
Gram-Negative Bacterial Infections - drug therapy
Gram-Negative Bacterial Infections - epidemiology
Gynecology. Andrology. Obstetrics
Health aspects
Human bacterial diseases
Humans
Infant, Newborn
Infant, Premature
Infant, Premature, Diseases - epidemiology
Infant, Premature, Diseases - etiology
Infant, Very Low Birth Weight
Infants (Premature)
Infectious diseases
Medical sciences
Medical treatment
Mortality
Moxalactam
Pediatrics
Pregnancy. Fetus. Placenta
Premature infants
Prospective Studies
Registries
Risk Factors
Studies
Superinfection - epidemiology
Superinfection - etiology
title The Association of Third-Generation Cephalosporin Use and Invasive Candidiasis in Extremely Low Birth-Weight Infants
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