Effect of Interferon-Gamma on Hepatic Fibrosis in Chronic Hepatitis B Virus Infection: A Randomized Controlled Study

Background & Aims: Hepatic fibrosis due to chronic HBV infection has enormous socioeconomic impact. Besides strategies targeting virus elimination, prevention or reversal of liver fibrosis is amenable. Given the antifibrotic activity of interferon-gamma (IFN-γ), a randomized open-labeled multice...

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Veröffentlicht in:	Clinical gastroenterology and hepatology 2005-08, Vol.3 (8), p.819-828
Hauptverfasser:	Weng, Hong-Lei, Wang, Bao-En, Jia, Ji-Dong, Wu, Wan-Fen, Xian, Jian-Zhong, Mertens, Peter R., Cai, Wei-Min, Dooley, Steven
Format:	Artikel
Sprache:	eng
Schlagworte:	Actins - analysis Adult Anti-Infective Agents - therapeutic use Biopsy, Needle Collagen Type III - metabolism Collagen Type IV - metabolism Drug Therapy, Combination Female Glycyrrhizic Acid - therapeutic use Hepatitis B, Chronic - complications Humans Hyaluronic Acid - metabolism Injections, Intramuscular Interferon-gamma - therapeutic use Laminin - metabolism Liver - pathology Liver Cirrhosis - drug therapy Liver Cirrhosis - etiology Liver Cirrhosis - metabolism Male Muscle, Smooth - chemistry Potassium Magnesium Aspartate - therapeutic use Prospective Studies Severity of Illness Index Smad2 Protein - metabolism
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