The effect of various methods of psoriasis treatment on somatotrophin axis hormones in serum
Summary Objective: To investigate the effect of pharmacotherapy and phototherapy on the concentration of hormones of the somatotrophin axis [growth hormone (GH), insulin‐like growth factor‐I (IGF‐I) and insulin‐like growth factor binding protein‐3 (IGFBP‐3)] in the serum of patients with psoriasis...
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| Veröffentlicht in: | Journal of clinical pharmacy and therapeutics 2006-08, Vol.31 (4), p.343-349 |
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| container_title | Journal of clinical pharmacy and therapeutics |
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| creator | Damasiewicz-Bodzek, A. Kos-Kudła, B. Suwała-Jurczyk, B. |
| description | Summary
Objective: To investigate the effect of pharmacotherapy and phototherapy on the concentration of hormones of the somatotrophin axis [growth hormone (GH), insulin‐like growth factor‐I (IGF‐I) and insulin‐like growth factor binding protein‐3 (IGFBP‐3)] in the serum of patients with psoriasis in exacerbation and remission.
Methods: GH and IGFBP‐3 in serum were determined by immunoradiometric assay (IRMA), and IGF‐I concentrations – by radioimmunological assay (RIA). The dermatological state was assessed by the psoriasis area and severity index (PASI).
Results: There was no significant difference in the GH concentrations in patients both in exacerbation and remission, irrespective of therapy applied. However, in the group treated by phototherapy a significant increase in IGFBP‐3 secretion was observed, whereas in the group treated with cyclosporin A – a significant increase in IGF‐I secretion was observed in remission.
Conclusion: Different methods of treatment have different effects on the secretion of somatotrophin axis hormones, but generally the hormone concentrations do not return to the values observed in healthy people. The therapeutic actions of the drugs concerned are not fully known and require further investigations. |
| doi_str_mv | 10.1111/j.1365-2710.2006.00747.x |
| format | Article |
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Objective: To investigate the effect of pharmacotherapy and phototherapy on the concentration of hormones of the somatotrophin axis [growth hormone (GH), insulin‐like growth factor‐I (IGF‐I) and insulin‐like growth factor binding protein‐3 (IGFBP‐3)] in the serum of patients with psoriasis in exacerbation and remission.
Methods: GH and IGFBP‐3 in serum were determined by immunoradiometric assay (IRMA), and IGF‐I concentrations – by radioimmunological assay (RIA). The dermatological state was assessed by the psoriasis area and severity index (PASI).
Results: There was no significant difference in the GH concentrations in patients both in exacerbation and remission, irrespective of therapy applied. However, in the group treated by phototherapy a significant increase in IGFBP‐3 secretion was observed, whereas in the group treated with cyclosporin A – a significant increase in IGF‐I secretion was observed in remission.
Conclusion: Different methods of treatment have different effects on the secretion of somatotrophin axis hormones, but generally the hormone concentrations do not return to the values observed in healthy people. The therapeutic actions of the drugs concerned are not fully known and require further investigations.</description><identifier>ISSN: 0269-4727</identifier><identifier>EISSN: 1365-2710</identifier><identifier>DOI: 10.1111/j.1365-2710.2006.00747.x</identifier><identifier>PMID: 16882103</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Publishing Ltd</publisher><subject>acitretin ; Acitretin - therapeutic use ; Adult ; Biological and medical sciences ; Case-Control Studies ; cyclosporin A ; Dermatology ; Female ; Growth Hormone - blood ; Humans ; hydroxyurea ; Hydroxyurea - therapeutic use ; Insulin-Like Growth Factor Binding Protein 3 - blood ; Insulin-Like Growth Factor I - metabolism ; Keratolytic Agents - therapeutic use ; Male ; Medical sciences ; Pharmacology. Drug treatments ; phototherapy ; Phototherapy - methods ; psoriasis ; Psoriasis - blood ; Psoriasis - drug therapy ; Psoriasis - therapy ; Psoriasis. Parapsoriasis. Lichen ; Severity of Illness Index ; somatotrophin axis hormones</subject><ispartof>Journal of clinical pharmacy and therapeutics, 2006-08, Vol.31 (4), p.343-349</ispartof><rights>2006 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4857-fbda9abdf2861aa5a3bfb56003009b20801ab83a8a800c80b7ecef937daec2833</citedby><cites>FETCH-LOGICAL-c4857-fbda9abdf2861aa5a3bfb56003009b20801ab83a8a800c80b7ecef937daec2833</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fj.1365-2710.2006.00747.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fj.1365-2710.2006.00747.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=17961118$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16882103$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Damasiewicz-Bodzek, A.</creatorcontrib><creatorcontrib>Kos-Kudła, B.</creatorcontrib><creatorcontrib>Suwała-Jurczyk, B.</creatorcontrib><title>The effect of various methods of psoriasis treatment on somatotrophin axis hormones in serum</title><title>Journal of clinical pharmacy and therapeutics</title><addtitle>J Clin Pharm Ther</addtitle><description>Summary
Objective: To investigate the effect of pharmacotherapy and phototherapy on the concentration of hormones of the somatotrophin axis [growth hormone (GH), insulin‐like growth factor‐I (IGF‐I) and insulin‐like growth factor binding protein‐3 (IGFBP‐3)] in the serum of patients with psoriasis in exacerbation and remission.
Methods: GH and IGFBP‐3 in serum were determined by immunoradiometric assay (IRMA), and IGF‐I concentrations – by radioimmunological assay (RIA). The dermatological state was assessed by the psoriasis area and severity index (PASI).
Results: There was no significant difference in the GH concentrations in patients both in exacerbation and remission, irrespective of therapy applied. However, in the group treated by phototherapy a significant increase in IGFBP‐3 secretion was observed, whereas in the group treated with cyclosporin A – a significant increase in IGF‐I secretion was observed in remission.
Conclusion: Different methods of treatment have different effects on the secretion of somatotrophin axis hormones, but generally the hormone concentrations do not return to the values observed in healthy people. The therapeutic actions of the drugs concerned are not fully known and require further investigations.</description><subject>acitretin</subject><subject>Acitretin - therapeutic use</subject><subject>Adult</subject><subject>Biological and medical sciences</subject><subject>Case-Control Studies</subject><subject>cyclosporin A</subject><subject>Dermatology</subject><subject>Female</subject><subject>Growth Hormone - blood</subject><subject>Humans</subject><subject>hydroxyurea</subject><subject>Hydroxyurea - therapeutic use</subject><subject>Insulin-Like Growth Factor Binding Protein 3 - blood</subject><subject>Insulin-Like Growth Factor I - metabolism</subject><subject>Keratolytic Agents - therapeutic use</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Pharmacology. Drug treatments</subject><subject>phototherapy</subject><subject>Phototherapy - methods</subject><subject>psoriasis</subject><subject>Psoriasis - blood</subject><subject>Psoriasis - drug therapy</subject><subject>Psoriasis - therapy</subject><subject>Psoriasis. Parapsoriasis. Lichen</subject><subject>Severity of Illness Index</subject><subject>somatotrophin axis hormones</subject><issn>0269-4727</issn><issn>1365-2710</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2006</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkEFv0zAUxy0EYmXwFVAucEt5sRvbOXBAZQymatuhCGlCsl6SZ9UliYudju7b49Bqu-KLrfd-fz_7x1hWwLxI68N2XghZ5lylAgeQcwC1UPPDMzZ7bDxnM-CyyheKqzP2KsYtJFJx8ZKdFVJrXoCYsZ_rDWVkLTVj5m12j8H5fcx6Gje-jVNpF31wGF3MxkA49jQkcsii73H0Y_C7jRsyPKT-xofeDxSzVIgU9v1r9sJiF-nNaT9n379crJdf89XN5bflp1XeLHSpclu3WGHdWq5lgViiqG1dSgABUNUcNBRYa4EaNUCjoVbUkK2EapEaroU4Z--P9-6C_72nOJrexYa6DgdKvzFSK-CinEB9BJvgYwxkzS64HsODKcBMZs3WTALNJNBMZs0_s-aQom9PM_Z1T-1T8KQyAe9OAMYGOxtwaFx84lQl0wCduI9H7o_r6OG_H2CulrfrdEr5_Jh3caTDYx7DLyOVUKX5cX1pVnfLa_n56s5U4i_aeaUp</recordid><startdate>200608</startdate><enddate>200608</enddate><creator>Damasiewicz-Bodzek, A.</creator><creator>Kos-Kudła, B.</creator><creator>Suwała-Jurczyk, B.</creator><general>Blackwell Publishing Ltd</general><general>Blackwell</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>200608</creationdate><title>The effect of various methods of psoriasis treatment on somatotrophin axis hormones in serum</title><author>Damasiewicz-Bodzek, A. ; Kos-Kudła, B. ; Suwała-Jurczyk, B.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4857-fbda9abdf2861aa5a3bfb56003009b20801ab83a8a800c80b7ecef937daec2833</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2006</creationdate><topic>acitretin</topic><topic>Acitretin - therapeutic use</topic><topic>Adult</topic><topic>Biological and medical sciences</topic><topic>Case-Control Studies</topic><topic>cyclosporin A</topic><topic>Dermatology</topic><topic>Female</topic><topic>Growth Hormone - blood</topic><topic>Humans</topic><topic>hydroxyurea</topic><topic>Hydroxyurea - therapeutic use</topic><topic>Insulin-Like Growth Factor Binding Protein 3 - blood</topic><topic>Insulin-Like Growth Factor I - metabolism</topic><topic>Keratolytic Agents - therapeutic use</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Pharmacology. Drug treatments</topic><topic>phototherapy</topic><topic>Phototherapy - methods</topic><topic>psoriasis</topic><topic>Psoriasis - blood</topic><topic>Psoriasis - drug therapy</topic><topic>Psoriasis - therapy</topic><topic>Psoriasis. Parapsoriasis. Lichen</topic><topic>Severity of Illness Index</topic><topic>somatotrophin axis hormones</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Damasiewicz-Bodzek, A.</creatorcontrib><creatorcontrib>Kos-Kudła, B.</creatorcontrib><creatorcontrib>Suwała-Jurczyk, B.</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of clinical pharmacy and therapeutics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Damasiewicz-Bodzek, A.</au><au>Kos-Kudła, B.</au><au>Suwała-Jurczyk, B.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The effect of various methods of psoriasis treatment on somatotrophin axis hormones in serum</atitle><jtitle>Journal of clinical pharmacy and therapeutics</jtitle><addtitle>J Clin Pharm Ther</addtitle><date>2006-08</date><risdate>2006</risdate><volume>31</volume><issue>4</issue><spage>343</spage><epage>349</epage><pages>343-349</pages><issn>0269-4727</issn><eissn>1365-2710</eissn><abstract>Summary
Objective: To investigate the effect of pharmacotherapy and phototherapy on the concentration of hormones of the somatotrophin axis [growth hormone (GH), insulin‐like growth factor‐I (IGF‐I) and insulin‐like growth factor binding protein‐3 (IGFBP‐3)] in the serum of patients with psoriasis in exacerbation and remission.
Methods: GH and IGFBP‐3 in serum were determined by immunoradiometric assay (IRMA), and IGF‐I concentrations – by radioimmunological assay (RIA). The dermatological state was assessed by the psoriasis area and severity index (PASI).
Results: There was no significant difference in the GH concentrations in patients both in exacerbation and remission, irrespective of therapy applied. However, in the group treated by phototherapy a significant increase in IGFBP‐3 secretion was observed, whereas in the group treated with cyclosporin A – a significant increase in IGF‐I secretion was observed in remission.
Conclusion: Different methods of treatment have different effects on the secretion of somatotrophin axis hormones, but generally the hormone concentrations do not return to the values observed in healthy people. The therapeutic actions of the drugs concerned are not fully known and require further investigations.</abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><pmid>16882103</pmid><doi>10.1111/j.1365-2710.2006.00747.x</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | acitretin Acitretin - therapeutic use Adult Biological and medical sciences Case-Control Studies cyclosporin A Dermatology Female Growth Hormone - blood Humans hydroxyurea Hydroxyurea - therapeutic use Insulin-Like Growth Factor Binding Protein 3 - blood Insulin-Like Growth Factor I - metabolism Keratolytic Agents - therapeutic use Male Medical sciences Pharmacology. Drug treatments phototherapy Phototherapy - methods psoriasis Psoriasis - blood Psoriasis - drug therapy Psoriasis - therapy Psoriasis. Parapsoriasis. Lichen Severity of Illness Index somatotrophin axis hormones |
| title | The effect of various methods of psoriasis treatment on somatotrophin axis hormones in serum |
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