Context-dependent behavioural and neuronal sensitization in striatum to MDMA (ecstasy) administration in rats

To investigate the neuronal mechanisms underlying the behavioural alterations that accompany repeated exposure to MDMA (ecstasy), we recorded the activity of > 200 striatal units in response to multiple, intermittent, locomotor‐activating doses (5.0 mg/kg) of MDMA. Rats were treated with once‐dai...

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Veröffentlicht in:	The European journal of neuroscience 2006-07, Vol.24 (1), p.217-228
Hauptverfasser:	Ball, Kevin T., Budreau, Daniel, Rebec, George V.
Format:	Artikel
Sprache:	eng
Schlagworte:	Action Potentials Animals Central Nervous System Stimulants - pharmacology context Corpus Striatum - drug effects Corpus Striatum - physiology Electrophysiology Male MDMA Motor Activity - drug effects N-Methyl-3,4-methylenedioxyamphetamine - pharmacology Neurons - drug effects Neurons - physiology Rats Rats, Sprague-Dawley sensitization single-unit electrophysiology striatum Time Factors
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