Stop signal response inhibition is not modulated by tryptophan depletion or the serotonin transporter polymorphism in healthy volunteers : implications for the 5-HT theory of impulsivity

Reduced serotonin neurotransmission is implicated in disorders of impulse control, but the involvement of serotonin in inhibitory processes in healthy human subjects remains unclear. To investigate the effects of an acute manipulation of serotonin and genotype at a functional polymorphism in a gene...

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Veröffentlicht in:	Psychopharmacologia 2005-11, Vol.182 (4), p.570-578
Hauptverfasser:	CLARK, L, ROISER, J. P, COOLS, R, RUBINSZTEIN, D. C, SAHAKIAN, B. J, ROBBINS, T. W
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adult Analysis of Variance Behavioral psychophysiology Biological and medical sciences Cross-Over Studies Diet, Protein-Restricted - methods Double-Blind Method Female Fundamental and applied biological sciences. Psychology Humans Impulsive Behavior - genetics Impulsive Behavior - metabolism Impulsive Behavior - physiopathology Inhibition (Psychology) Male Middle Aged Neuropsychological Tests Neurotransmission and behavior Polymorphism, Genetic Psychology. Psychoanalysis. Psychiatry Psychology. Psychophysiology Reaction Time Serotonin - metabolism Serotonin Plasma Membrane Transport Proteins - genetics Tryptophan - deficiency Tryptophan - physiology
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