Effect of Disrupted SOX18 Transcription Factor Function on Tumor Growth, Vascularization, and Endothelial Development

Background: The growth of solid tumors depends on establishing blood supply; thus, inhibiting tumor angiogenesis has been a long-term goal in cancer therapy. The SOX18 transcription factor is a key regulator of murine and human blood vessel formation. Methods: We established allograft melanoma tumor...

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Veröffentlicht in:	JNCI : Journal of the National Cancer Institute 2006-08, Vol.98 (15), p.1060-1067
Hauptverfasser:	Young, Neville, Hahn, Christopher N., Poh, Alisa, Dong, Carolyn, Wilhelm, Dagmar, Olsson, Jane, Muscat, George E. O., Parsons, Peter, Gamble, Jennifer R., Koopman, Peter
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenoviridae Animal tumors. Experimental tumors Animals Antigens - analysis Biological and medical sciences Blotting, Northern Breast cancer Breast Neoplasms - blood supply Breast Neoplasms - genetics Breast Neoplasms - metabolism Cell adhesion & migration Cell Movement Cell Proliferation Colorectal Neoplasms - metabolism Embryo, Mammalian - metabolism Endothelium, Vascular - growth & development Endothelium, Vascular - metabolism Experimental tumors, general aspects Gene Expression Regulation, Neoplastic Genetic markers High Mobility Group Proteins - genetics High Mobility Group Proteins - metabolism Humans Immunohistochemistry In Situ Hybridization Medical sciences Melanoma - blood supply Melanoma - genetics Melanoma - metabolism Mice Mice, Inbred C57BL Mutation Neovascularization, Pathologic - metabolism Platelet Endothelial Cell Adhesion Molecule-1 - analysis Proteoglycans - analysis Rodents Skin cancer SOXF Transcription Factors Transcription Factors - genetics Transcription Factors - metabolism Transgenic animals Transplantation, Homologous Tumors Umbilical Veins Up-Regulation
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