Complete androgen ablation suppresses prostate stem cell antigen (PSCA) mRNA expression in human prostate carcinoma

BACKGROUND Prostate stem cell antigen (PSCA) is a recently identified glycosylphosphatidylinositol (GPI)‐anchored cell surface protein belonging to the Thy‐1/Ly‐6 family of cell surface antigens. Prior data in prostate cancers indicated that PSCA is directly regulated by androgens and PSCA expressio...

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Veröffentlicht in:	The Prostate 2005-12, Vol.65 (4), p.299-305
Hauptverfasser:	Zhigang, Zhao, Wenlu, Shen
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Aged, 80 and over Androgen Antagonists - therapeutic use Anilides - therapeutic use Antigens, Neoplasm Biological and medical sciences Biopsy complete androgen ablation (CAA) Follow-Up Studies GPI-Linked Proteins Gynecology. Andrology. Obstetrics Humans In Situ Hybridization Male Medical sciences Membrane Glycoproteins - antagonists & inhibitors Membrane Glycoproteins - biosynthesis Middle Aged Neoplasm Proteins - antagonists & inhibitors Neoplasm Proteins - biosynthesis Neoplasms, Hormone-Dependent - drug therapy Neoplasms, Hormone-Dependent - genetics Neoplasms, Hormone-Dependent - metabolism Neoplasms, Hormone-Dependent - pathology Nephrology. Urinary tract diseases Nitriles Predictive Value of Tests prostate carcinoma prostate stem cell antigen (PSCA) Prostatic Neoplasms - drug therapy Prostatic Neoplasms - genetics Prostatic Neoplasms - metabolism Prostatic Neoplasms - pathology RNA, Messenger - antagonists & inhibitors RNA, Messenger - biosynthesis RNA, Messenger - genetics RNA, Neoplasm - genetics Tosyl Compounds Tumors of the urinary system Urinary tract. Prostate gland
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