Outcome in a hepatitis C (genotype 1b) single source outbreak in Germany—a 25-year multicenter study
The natural course of the hepatitis C virus genotype 1b (HCV-1b) infection is still unclear but important for therapeutic decisions. There are few unbiased long-term follow-up studies with known dates of infection. Between August 1978 and March 1979, 14 HCV-1b contaminated batches of anti-D immunogl...
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| Veröffentlicht in: | Journal of hepatology 2005-10, Vol.43 (4), p.590-598 |
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| creator | Wiese, Manfred Grüngreiff, Kurt Güthoff, Wolfgang Lafrenz, Michael Oesen, Ute Porst, Heiner |
| description | The natural course of the hepatitis C virus genotype 1b (HCV-1b) infection is still unclear but important for therapeutic decisions. There are few unbiased long-term follow-up studies with known dates of infection.
Between August 1978 and March 1979, 14 HCV-1b contaminated batches of anti-D immunoglobulin had been administered to 2867 women for prophylaxis of rhesus isoimmunization throughout East Germany. We reexamined 1980 women, representing 70% of the total cohort of 15 centers.
After application of the contaminated anti-D, 93% of the recipients developed an acute hepatitis C. After 25 years, 86% of the 1833 affected women still tested positive for hepatitis C virus antibodies and 46% for HCV RNA. Only nine (0.5%) had overt liver cirrhosis, 30 women (1.5%) developed precirrhotic stages and one HCC was diagnosed. Ten (0.5%) died of HCV related complications, half of these related to additional comorbidity. In the last 5 years, a continuous, but low increase of fibrotic scores was observed.
Young women without comorbidity may clear HCV (1b) infection in more than half of the cases, or develop mild chronic hepatitis C. We confirmed the low risk of progression to cirrhosis in this cohort within 25 years. |
| doi_str_mv | 10.1016/j.jhep.2005.04.007 |
| format | Article |
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Between August 1978 and March 1979, 14 HCV-1b contaminated batches of anti-D immunoglobulin had been administered to 2867 women for prophylaxis of rhesus isoimmunization throughout East Germany. We reexamined 1980 women, representing 70% of the total cohort of 15 centers.
After application of the contaminated anti-D, 93% of the recipients developed an acute hepatitis C. After 25 years, 86% of the 1833 affected women still tested positive for hepatitis C virus antibodies and 46% for HCV RNA. Only nine (0.5%) had overt liver cirrhosis, 30 women (1.5%) developed precirrhotic stages and one HCC was diagnosed. Ten (0.5%) died of HCV related complications, half of these related to additional comorbidity. In the last 5 years, a continuous, but low increase of fibrotic scores was observed.
Young women without comorbidity may clear HCV (1b) infection in more than half of the cases, or develop mild chronic hepatitis C. We confirmed the low risk of progression to cirrhosis in this cohort within 25 years.</description><identifier>ISSN: 0168-8278</identifier><identifier>EISSN: 1600-0641</identifier><identifier>DOI: 10.1016/j.jhep.2005.04.007</identifier><identifier>PMID: 16237783</identifier><language>eng</language><publisher>Netherlands: Elsevier B.V</publisher><subject>Adult ; Age of Onset ; Alcohol Drinking ; Anti-HCV ; Carcinoma, Hepatocellular - epidemiology ; Disease Outbreaks ; Female ; Fibrosis ; Genotype ; Germany - epidemiology ; HCV genotypes ; Hepacivirus - genetics ; Hepatitis C ; Hepatitis C - complications ; Hepatitis C - epidemiology ; Histology ; Humans ; Liver cirrhosis ; Liver Cirrhosis - epidemiology ; Liver Neoplasms - epidemiology ; Male ; Middle Aged ; Natural history ; Outcome ; PCR ; Risk Factors ; Viral Load ; Virology</subject><ispartof>Journal of hepatology, 2005-10, Vol.43 (4), p.590-598</ispartof><rights>2005 European Association for the Study of the Liver</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c420t-7bbdb7621372c933f04beed524bd6d26fd81df33fcfaf8c08017f3c17bb1d87c3</citedby><cites>FETCH-LOGICAL-c420t-7bbdb7621372c933f04beed524bd6d26fd81df33fcfaf8c08017f3c17bb1d87c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S016882780500317X$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65534</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16237783$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Wiese, Manfred</creatorcontrib><creatorcontrib>Grüngreiff, Kurt</creatorcontrib><creatorcontrib>Güthoff, Wolfgang</creatorcontrib><creatorcontrib>Lafrenz, Michael</creatorcontrib><creatorcontrib>Oesen, Ute</creatorcontrib><creatorcontrib>Porst, Heiner</creatorcontrib><creatorcontrib>East German Hepatitis C Study Group</creatorcontrib><title>Outcome in a hepatitis C (genotype 1b) single source outbreak in Germany—a 25-year multicenter study</title><title>Journal of hepatology</title><addtitle>J Hepatol</addtitle><description>The natural course of the hepatitis C virus genotype 1b (HCV-1b) infection is still unclear but important for therapeutic decisions. There are few unbiased long-term follow-up studies with known dates of infection.
Between August 1978 and March 1979, 14 HCV-1b contaminated batches of anti-D immunoglobulin had been administered to 2867 women for prophylaxis of rhesus isoimmunization throughout East Germany. We reexamined 1980 women, representing 70% of the total cohort of 15 centers.
After application of the contaminated anti-D, 93% of the recipients developed an acute hepatitis C. After 25 years, 86% of the 1833 affected women still tested positive for hepatitis C virus antibodies and 46% for HCV RNA. Only nine (0.5%) had overt liver cirrhosis, 30 women (1.5%) developed precirrhotic stages and one HCC was diagnosed. Ten (0.5%) died of HCV related complications, half of these related to additional comorbidity. In the last 5 years, a continuous, but low increase of fibrotic scores was observed.
Young women without comorbidity may clear HCV (1b) infection in more than half of the cases, or develop mild chronic hepatitis C. We confirmed the low risk of progression to cirrhosis in this cohort within 25 years.</description><subject>Adult</subject><subject>Age of Onset</subject><subject>Alcohol Drinking</subject><subject>Anti-HCV</subject><subject>Carcinoma, Hepatocellular - epidemiology</subject><subject>Disease Outbreaks</subject><subject>Female</subject><subject>Fibrosis</subject><subject>Genotype</subject><subject>Germany - epidemiology</subject><subject>HCV genotypes</subject><subject>Hepacivirus - genetics</subject><subject>Hepatitis C</subject><subject>Hepatitis C - complications</subject><subject>Hepatitis C - epidemiology</subject><subject>Histology</subject><subject>Humans</subject><subject>Liver cirrhosis</subject><subject>Liver Cirrhosis - epidemiology</subject><subject>Liver Neoplasms - epidemiology</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Natural history</subject><subject>Outcome</subject><subject>PCR</subject><subject>Risk Factors</subject><subject>Viral Load</subject><subject>Virology</subject><issn>0168-8278</issn><issn>1600-0641</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kM2KFDEURoM4OO3oC7iQrEQXVd6kqpMUuBkaHQcGZjOuQyq5GdPWT5ukhNr5EPOEPolpusGdq8DlnA9yCHnDoGbAxMd9vf-Oh5oDbGtoawD5jGyYAKhAtOw52RRIVYpLdUleprQHgAa69gW5ZII3UqpmQ_z9ku08Ig0TNbTMmRxySHRH3z_iNOf1gJT1H2gK0-OANM1LtEjnJfcRzY-jdYNxNNP65_eToXxbrWgiHZchB4tTxkhTXtz6ilx4MyR8fX6vyLcvnx92X6u7-5vb3fVdZVsOuZJ973opOGskt13TeGh7RLflbe-E48I7xZwvd-uNVxYUMOkby4rHnJK2uSLvTruHOP9cMGU9hmRxGMyE85K0UKLrhOgKyE-gjXNKEb0-xDCauGoG-lhX7_Wxrj7W1dDqUrdIb8_rSz-i-6eccxbg0wnA8sdfAaNONuBk0YWINms3h__t_wVoMI0Z</recordid><startdate>20051001</startdate><enddate>20051001</enddate><creator>Wiese, Manfred</creator><creator>Grüngreiff, Kurt</creator><creator>Güthoff, Wolfgang</creator><creator>Lafrenz, Michael</creator><creator>Oesen, Ute</creator><creator>Porst, Heiner</creator><general>Elsevier B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20051001</creationdate><title>Outcome in a hepatitis C (genotype 1b) single source outbreak in Germany—a 25-year multicenter study</title><author>Wiese, Manfred ; Grüngreiff, Kurt ; Güthoff, Wolfgang ; Lafrenz, Michael ; Oesen, Ute ; Porst, Heiner</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c420t-7bbdb7621372c933f04beed524bd6d26fd81df33fcfaf8c08017f3c17bb1d87c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>Adult</topic><topic>Age of Onset</topic><topic>Alcohol Drinking</topic><topic>Anti-HCV</topic><topic>Carcinoma, Hepatocellular - epidemiology</topic><topic>Disease Outbreaks</topic><topic>Female</topic><topic>Fibrosis</topic><topic>Genotype</topic><topic>Germany - epidemiology</topic><topic>HCV genotypes</topic><topic>Hepacivirus - genetics</topic><topic>Hepatitis C</topic><topic>Hepatitis C - complications</topic><topic>Hepatitis C - epidemiology</topic><topic>Histology</topic><topic>Humans</topic><topic>Liver cirrhosis</topic><topic>Liver Cirrhosis - epidemiology</topic><topic>Liver Neoplasms - epidemiology</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Natural history</topic><topic>Outcome</topic><topic>PCR</topic><topic>Risk Factors</topic><topic>Viral Load</topic><topic>Virology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Wiese, Manfred</creatorcontrib><creatorcontrib>Grüngreiff, Kurt</creatorcontrib><creatorcontrib>Güthoff, Wolfgang</creatorcontrib><creatorcontrib>Lafrenz, Michael</creatorcontrib><creatorcontrib>Oesen, Ute</creatorcontrib><creatorcontrib>Porst, Heiner</creatorcontrib><creatorcontrib>East German Hepatitis C Study Group</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of hepatology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wiese, Manfred</au><au>Grüngreiff, Kurt</au><au>Güthoff, Wolfgang</au><au>Lafrenz, Michael</au><au>Oesen, Ute</au><au>Porst, Heiner</au><aucorp>East German Hepatitis C Study Group</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Outcome in a hepatitis C (genotype 1b) single source outbreak in Germany—a 25-year multicenter study</atitle><jtitle>Journal of hepatology</jtitle><addtitle>J Hepatol</addtitle><date>2005-10-01</date><risdate>2005</risdate><volume>43</volume><issue>4</issue><spage>590</spage><epage>598</epage><pages>590-598</pages><issn>0168-8278</issn><eissn>1600-0641</eissn><abstract>The natural course of the hepatitis C virus genotype 1b (HCV-1b) infection is still unclear but important for therapeutic decisions. There are few unbiased long-term follow-up studies with known dates of infection.
Between August 1978 and March 1979, 14 HCV-1b contaminated batches of anti-D immunoglobulin had been administered to 2867 women for prophylaxis of rhesus isoimmunization throughout East Germany. We reexamined 1980 women, representing 70% of the total cohort of 15 centers.
After application of the contaminated anti-D, 93% of the recipients developed an acute hepatitis C. After 25 years, 86% of the 1833 affected women still tested positive for hepatitis C virus antibodies and 46% for HCV RNA. Only nine (0.5%) had overt liver cirrhosis, 30 women (1.5%) developed precirrhotic stages and one HCC was diagnosed. Ten (0.5%) died of HCV related complications, half of these related to additional comorbidity. In the last 5 years, a continuous, but low increase of fibrotic scores was observed.
Young women without comorbidity may clear HCV (1b) infection in more than half of the cases, or develop mild chronic hepatitis C. We confirmed the low risk of progression to cirrhosis in this cohort within 25 years.</abstract><cop>Netherlands</cop><pub>Elsevier B.V</pub><pmid>16237783</pmid><doi>10.1016/j.jhep.2005.04.007</doi><tpages>9</tpages></addata></record> |
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| subjects | Adult Age of Onset Alcohol Drinking Anti-HCV Carcinoma, Hepatocellular - epidemiology Disease Outbreaks Female Fibrosis Genotype Germany - epidemiology HCV genotypes Hepacivirus - genetics Hepatitis C Hepatitis C - complications Hepatitis C - epidemiology Histology Humans Liver cirrhosis Liver Cirrhosis - epidemiology Liver Neoplasms - epidemiology Male Middle Aged Natural history Outcome PCR Risk Factors Viral Load Virology |
| title | Outcome in a hepatitis C (genotype 1b) single source outbreak in Germany—a 25-year multicenter study |
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