Use of nonaspirin NSAIDs and risk of lung cancer
Epidemiologic evidence is conflicting regarding the potential for nonsteroidal antiinflammatory drugs (NSAIDs) to lower the risk of lung cancer. We thus determined the incidence of lung cancer among a cohort of over 242,000 adults in Denmark who had been issued NSAID prescriptions during 1991–2002 a...
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| Veröffentlicht in: | International journal of cancer 2005-12, Vol.117 (5), p.873-876 |
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| container_title | International journal of cancer |
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| creator | Skriver, Mette Vinther Nørgaard, Mette Poulsen, Aslak Harbo Friis, Søren Harving, Henrik Fryzek, Jon McLaughlin, Joseph K. Blot, William J. Olsen, Jørgen H. Sørensen, Henrik Toft |
| description | Epidemiologic evidence is conflicting regarding the potential for nonsteroidal antiinflammatory drugs (NSAIDs) to lower the risk of lung cancer. We thus determined the incidence of lung cancer among a cohort of over 242,000 adults in Denmark who had been issued NSAID prescriptions during 1991–2002 and calculated the relative risks of this cancer according to the numbers of prescriptions received. Similar analyses were conducted among a subset with chronic obstructive pulmonary disease, of whom the large majority was assumed to have been smokers, as an indirect control for smoking. Utilization of Danish registries ensured essentially complete and unbiased ascertainment of prescriptions and cancer outcomes. The relative risks of lung cancer among NSAID users redeeming 10 or more prescriptions vs. nonusers in the general population and among chronic obstructive pulmonary disease patients were 1.51 (95% CI = 1.33–1.71) and 1.55 (95% CI = 0.93–2.60) and tended to decline with decreasing numbers of NSAIDs prescribed. Separate analyses for adenocarcinoma and squamous cell carcinoma also failed to show reduced risks among NSAID users. Confounding by indication may have contributed to the increased risks, but the study provides no evidence to suggest that recent NSAID intake may be protective for lung cancer. © 2005 Wiley‐Liss, Inc. |
| doi_str_mv | 10.1002/ijc.21260 |
| format | Article |
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We thus determined the incidence of lung cancer among a cohort of over 242,000 adults in Denmark who had been issued NSAID prescriptions during 1991–2002 and calculated the relative risks of this cancer according to the numbers of prescriptions received. Similar analyses were conducted among a subset with chronic obstructive pulmonary disease, of whom the large majority was assumed to have been smokers, as an indirect control for smoking. Utilization of Danish registries ensured essentially complete and unbiased ascertainment of prescriptions and cancer outcomes. The relative risks of lung cancer among NSAID users redeeming 10 or more prescriptions vs. nonusers in the general population and among chronic obstructive pulmonary disease patients were 1.51 (95% CI = 1.33–1.71) and 1.55 (95% CI = 0.93–2.60) and tended to decline with decreasing numbers of NSAIDs prescribed. Separate analyses for adenocarcinoma and squamous cell carcinoma also failed to show reduced risks among NSAID users. Confounding by indication may have contributed to the increased risks, but the study provides no evidence to suggest that recent NSAID intake may be protective for lung cancer. © 2005 Wiley‐Liss, Inc.</description><identifier>ISSN: 0020-7136</identifier><identifier>EISSN: 1097-0215</identifier><identifier>DOI: 10.1002/ijc.21260</identifier><identifier>PMID: 15957171</identifier><identifier>CODEN: IJCNAW</identifier><language>eng</language><publisher>Hoboken: Wiley Subscription Services, Inc., A Wiley Company</publisher><subject>Aged ; Anti-Inflammatory Agents, Non-Steroidal - administration & dosage ; Biological and medical sciences ; chronic obstructive pulmonary disease ; Cohort Studies ; Denmark - epidemiology ; epidemiology ; Female ; Humans ; Incidence ; Lung Neoplasms - complications ; Lung Neoplasms - epidemiology ; Male ; Medical sciences ; non‐steroidal anti‐inflammatory drugs ; Pneumology ; population‐based ; Pulmonary Disease, Chronic Obstructive - complications ; Registries ; risk of lung cancer ; Tumors ; Tumors of the respiratory system and mediastinum</subject><ispartof>International journal of cancer, 2005-12, Vol.117 (5), p.873-876</ispartof><rights>Copyright © 2005 Wiley‐Liss, Inc.</rights><rights>2006 INIST-CNRS</rights><rights>Copyright 2005 Wiley-Liss, Inc</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3840-b8d5a758a7249e14313bce9426ca06424acbe65512cbcf0bf8af381ece2c3c2c3</citedby><cites>FETCH-LOGICAL-c3840-b8d5a758a7249e14313bce9426ca06424acbe65512cbcf0bf8af381ece2c3c2c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fijc.21260$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fijc.21260$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=17231406$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15957171$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Skriver, Mette Vinther</creatorcontrib><creatorcontrib>Nørgaard, Mette</creatorcontrib><creatorcontrib>Poulsen, Aslak Harbo</creatorcontrib><creatorcontrib>Friis, Søren</creatorcontrib><creatorcontrib>Harving, Henrik</creatorcontrib><creatorcontrib>Fryzek, Jon</creatorcontrib><creatorcontrib>McLaughlin, Joseph K.</creatorcontrib><creatorcontrib>Blot, William J.</creatorcontrib><creatorcontrib>Olsen, Jørgen H.</creatorcontrib><creatorcontrib>Sørensen, Henrik Toft</creatorcontrib><title>Use of nonaspirin NSAIDs and risk of lung cancer</title><title>International journal of cancer</title><addtitle>Int J Cancer</addtitle><description>Epidemiologic evidence is conflicting regarding the potential for nonsteroidal antiinflammatory drugs (NSAIDs) to lower the risk of lung cancer. We thus determined the incidence of lung cancer among a cohort of over 242,000 adults in Denmark who had been issued NSAID prescriptions during 1991–2002 and calculated the relative risks of this cancer according to the numbers of prescriptions received. Similar analyses were conducted among a subset with chronic obstructive pulmonary disease, of whom the large majority was assumed to have been smokers, as an indirect control for smoking. Utilization of Danish registries ensured essentially complete and unbiased ascertainment of prescriptions and cancer outcomes. The relative risks of lung cancer among NSAID users redeeming 10 or more prescriptions vs. nonusers in the general population and among chronic obstructive pulmonary disease patients were 1.51 (95% CI = 1.33–1.71) and 1.55 (95% CI = 0.93–2.60) and tended to decline with decreasing numbers of NSAIDs prescribed. Separate analyses for adenocarcinoma and squamous cell carcinoma also failed to show reduced risks among NSAID users. Confounding by indication may have contributed to the increased risks, but the study provides no evidence to suggest that recent NSAID intake may be protective for lung cancer. © 2005 Wiley‐Liss, Inc.</description><subject>Aged</subject><subject>Anti-Inflammatory Agents, Non-Steroidal - administration & dosage</subject><subject>Biological and medical sciences</subject><subject>chronic obstructive pulmonary disease</subject><subject>Cohort Studies</subject><subject>Denmark - epidemiology</subject><subject>epidemiology</subject><subject>Female</subject><subject>Humans</subject><subject>Incidence</subject><subject>Lung Neoplasms - complications</subject><subject>Lung Neoplasms - epidemiology</subject><subject>Male</subject><subject>Medical sciences</subject><subject>non‐steroidal anti‐inflammatory drugs</subject><subject>Pneumology</subject><subject>population‐based</subject><subject>Pulmonary Disease, Chronic Obstructive - complications</subject><subject>Registries</subject><subject>risk of lung cancer</subject><subject>Tumors</subject><subject>Tumors of the respiratory system and mediastinum</subject><issn>0020-7136</issn><issn>1097-0215</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqF0M9LwzAUwPEgipvTg_-A9KLgodt7aZK2R5m_JkMPunNIs1Qyu3YmFtl_b2YLO4mHkMP78B58CTlHGCMAndiVHlOkAg7IECFPY6DID8kwzCBOMREDcuL9CgCRAzsmA-Q5TzHFIYGFN1FTRnVTK7-xztbR8-vN7NZHql5GzvqP3bRq6_dIq1obd0qOSlV5c9b_I7K4v3ubPsbzl4fZ9GYe6yRjEBfZkquUZyqlLDfIEkwKbXJGhVYgGGVKF0ZwjlQXuoSizFSZZGi0oTrR4Y3IVbd345rP1vgvubZem6pStWlaL0Um8pwC_gsxFSznPAvwuoPaNd47U8qNs2vlthJB7jrK0FH-dgz2ol_aFmuz3Ms-XACXPVBeq6p0IY71e5fSBBmI4Cad-7aV2f59Uc6ept3pH2yshr8</recordid><startdate>20051210</startdate><enddate>20051210</enddate><creator>Skriver, Mette Vinther</creator><creator>Nørgaard, Mette</creator><creator>Poulsen, Aslak Harbo</creator><creator>Friis, Søren</creator><creator>Harving, Henrik</creator><creator>Fryzek, Jon</creator><creator>McLaughlin, Joseph K.</creator><creator>Blot, William J.</creator><creator>Olsen, Jørgen H.</creator><creator>Sørensen, Henrik Toft</creator><general>Wiley Subscription Services, Inc., A Wiley Company</general><general>Wiley-Liss</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7U1</scope><scope>7U2</scope><scope>7U7</scope><scope>C1K</scope><scope>7X8</scope></search><sort><creationdate>20051210</creationdate><title>Use of nonaspirin NSAIDs and risk of lung cancer</title><author>Skriver, Mette Vinther ; Nørgaard, Mette ; Poulsen, Aslak Harbo ; Friis, Søren ; Harving, Henrik ; Fryzek, Jon ; McLaughlin, Joseph K. ; Blot, William J. ; Olsen, Jørgen H. ; Sørensen, Henrik Toft</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3840-b8d5a758a7249e14313bce9426ca06424acbe65512cbcf0bf8af381ece2c3c2c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>Aged</topic><topic>Anti-Inflammatory Agents, Non-Steroidal - administration & dosage</topic><topic>Biological and medical sciences</topic><topic>chronic obstructive pulmonary disease</topic><topic>Cohort Studies</topic><topic>Denmark - epidemiology</topic><topic>epidemiology</topic><topic>Female</topic><topic>Humans</topic><topic>Incidence</topic><topic>Lung Neoplasms - complications</topic><topic>Lung Neoplasms - epidemiology</topic><topic>Male</topic><topic>Medical sciences</topic><topic>non‐steroidal anti‐inflammatory drugs</topic><topic>Pneumology</topic><topic>population‐based</topic><topic>Pulmonary Disease, Chronic Obstructive - complications</topic><topic>Registries</topic><topic>risk of lung cancer</topic><topic>Tumors</topic><topic>Tumors of the respiratory system and mediastinum</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Skriver, Mette Vinther</creatorcontrib><creatorcontrib>Nørgaard, Mette</creatorcontrib><creatorcontrib>Poulsen, Aslak Harbo</creatorcontrib><creatorcontrib>Friis, Søren</creatorcontrib><creatorcontrib>Harving, Henrik</creatorcontrib><creatorcontrib>Fryzek, Jon</creatorcontrib><creatorcontrib>McLaughlin, Joseph K.</creatorcontrib><creatorcontrib>Blot, William J.</creatorcontrib><creatorcontrib>Olsen, Jørgen H.</creatorcontrib><creatorcontrib>Sørensen, Henrik Toft</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Risk Abstracts</collection><collection>Safety Science and Risk</collection><collection>Toxicology Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><collection>MEDLINE - Academic</collection><jtitle>International journal of cancer</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Skriver, Mette Vinther</au><au>Nørgaard, Mette</au><au>Poulsen, Aslak Harbo</au><au>Friis, Søren</au><au>Harving, Henrik</au><au>Fryzek, Jon</au><au>McLaughlin, Joseph K.</au><au>Blot, William J.</au><au>Olsen, Jørgen H.</au><au>Sørensen, Henrik Toft</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Use of nonaspirin NSAIDs and risk of lung cancer</atitle><jtitle>International journal of cancer</jtitle><addtitle>Int J Cancer</addtitle><date>2005-12-10</date><risdate>2005</risdate><volume>117</volume><issue>5</issue><spage>873</spage><epage>876</epage><pages>873-876</pages><issn>0020-7136</issn><eissn>1097-0215</eissn><coden>IJCNAW</coden><abstract>Epidemiologic evidence is conflicting regarding the potential for nonsteroidal antiinflammatory drugs (NSAIDs) to lower the risk of lung cancer. We thus determined the incidence of lung cancer among a cohort of over 242,000 adults in Denmark who had been issued NSAID prescriptions during 1991–2002 and calculated the relative risks of this cancer according to the numbers of prescriptions received. Similar analyses were conducted among a subset with chronic obstructive pulmonary disease, of whom the large majority was assumed to have been smokers, as an indirect control for smoking. Utilization of Danish registries ensured essentially complete and unbiased ascertainment of prescriptions and cancer outcomes. The relative risks of lung cancer among NSAID users redeeming 10 or more prescriptions vs. nonusers in the general population and among chronic obstructive pulmonary disease patients were 1.51 (95% CI = 1.33–1.71) and 1.55 (95% CI = 0.93–2.60) and tended to decline with decreasing numbers of NSAIDs prescribed. Separate analyses for adenocarcinoma and squamous cell carcinoma also failed to show reduced risks among NSAID users. Confounding by indication may have contributed to the increased risks, but the study provides no evidence to suggest that recent NSAID intake may be protective for lung cancer. © 2005 Wiley‐Liss, Inc.</abstract><cop>Hoboken</cop><pub>Wiley Subscription Services, Inc., A Wiley Company</pub><pmid>15957171</pmid><doi>10.1002/ijc.21260</doi><tpages>4</tpages></addata></record> |
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| subjects | Aged Anti-Inflammatory Agents, Non-Steroidal - administration & dosage Biological and medical sciences chronic obstructive pulmonary disease Cohort Studies Denmark - epidemiology epidemiology Female Humans Incidence Lung Neoplasms - complications Lung Neoplasms - epidemiology Male Medical sciences non‐steroidal anti‐inflammatory drugs Pneumology population‐based Pulmonary Disease, Chronic Obstructive - complications Registries risk of lung cancer Tumors Tumors of the respiratory system and mediastinum |
| title | Use of nonaspirin NSAIDs and risk of lung cancer |
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