Protection against Chronic Hepatitis C Virus Infection after Rechallenge with Homologous, but Not Heterologous, Genotypes in a Chimpanzee Model
An open question for hepatitis C virus (HCV) vaccine development is whether the various genotypes of this virus protect against the development of chronic infection after heterologous infection with different genotypes. We approached this question by challenging chimpanzees that had recovered from H...
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| Veröffentlicht in: | The Journal of infectious diseases 2005-11, Vol.192 (10), p.1701-1709 |
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| container_title | The Journal of infectious diseases |
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| creator | Prince, Alfred M. Brotman, Betsy Lee, Dong-Hun Pfahler, Wolfram Tricoche, Nancy Andrus, Linda Shata, Mohamed T. |
| description | An open question for hepatitis C virus (HCV) vaccine development is whether the various genotypes of this virus protect against the development of chronic infection after heterologous infection with different genotypes. We approached this question by challenging chimpanzees that had recovered from HCV genotype 1a or 1b infection with 6 heterologous genotypes as well as with a homologous genotype (for chimpanzees originally infected with genotype 1a). All 9 chimpanzees rechallenged with a homologous genotype developed self-limited infections. Of 11 chimpanzees challenged with 100 chimpanzee infectious doses of heterologous genotypes, 6 developed self-limited infections, with peak viral loads in acute-phase serum that were ∼5-fold lower than those seen during primary infections. One chimpanzee (which had recovered from genotype 1b infection and was rechallenged with genotype 6a) did not develop viremia but did show an anamnestic cell-mediated immune response after rechallenge. Four of the 11 chimpanzees rechallenged with heterologous genotypes developed chronic infections with the genotypes used for rechallenge. These findings suggest that a universally protective HCV vaccine may need to incorporate epitopes from multiple genotypes |
| doi_str_mv | 10.1086/496889 |
| format | Article |
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We approached this question by challenging chimpanzees that had recovered from HCV genotype 1a or 1b infection with 6 heterologous genotypes as well as with a homologous genotype (for chimpanzees originally infected with genotype 1a). All 9 chimpanzees rechallenged with a homologous genotype developed self-limited infections. Of 11 chimpanzees challenged with 100 chimpanzee infectious doses of heterologous genotypes, 6 developed self-limited infections, with peak viral loads in acute-phase serum that were ∼5-fold lower than those seen during primary infections. One chimpanzee (which had recovered from genotype 1b infection and was rechallenged with genotype 6a) did not develop viremia but did show an anamnestic cell-mediated immune response after rechallenge. Four of the 11 chimpanzees rechallenged with heterologous genotypes developed chronic infections with the genotypes used for rechallenge. These findings suggest that a universally protective HCV vaccine may need to incorporate epitopes from multiple genotypes</description><identifier>ISSN: 0022-1899</identifier><identifier>EISSN: 1537-6613</identifier><identifier>DOI: 10.1086/496889</identifier><identifier>PMID: 16235167</identifier><identifier>CODEN: JIDIAQ</identifier><language>eng</language><publisher>Chicago, IL: The University of Chicago Press</publisher><subject>Animals ; Biological and medical sciences ; Disease Models, Animal ; Enzyme linked immunospot assay ; Fundamental and applied biological sciences. Psychology ; Genotype ; Genotypes ; Hepacivirus ; Hepacivirus - classification ; Hepacivirus - genetics ; Hepacivirus - immunology ; Hepacivirus - pathogenicity ; Hepatitis C virus ; Hepatitis C, Chronic - immunology ; Hepatitis C, Chronic - prevention & control ; Hepatitis C, Chronic - virology ; Human viral diseases ; Humans ; Immunity ; Infections ; Infectious diseases ; Interferon-gamma - biosynthesis ; Medical sciences ; Microbiology ; Pan troglodytes - immunology ; Pan troglodytes - virology ; RNA ; RNA, Viral - blood ; RNA, Viral - immunology ; T lymphocytes ; Viral diseases ; Viral hepatitis ; Viral load ; Viremia ; Viremia - prevention & control ; Viremia - virology ; Viruses</subject><ispartof>The Journal of infectious diseases, 2005-11, Vol.192 (10), p.1701-1709</ispartof><rights>Copyright 2005 Infectious Diseases Society of America</rights><rights>2005 by the Infectious Diseases Society of America 2005</rights><rights>2006 INIST-CNRS</rights><rights>Copyright University of Chicago Press Nov 15, 2005</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c483t-fa4a7354a01aec97f31e5c23e98d3670cac57098c7daf4e8d825cadba4baf48e3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/20180001$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/20180001$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>314,780,784,803,27923,27924,58016,58249</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=17303243$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16235167$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Prince, Alfred M.</creatorcontrib><creatorcontrib>Brotman, Betsy</creatorcontrib><creatorcontrib>Lee, Dong-Hun</creatorcontrib><creatorcontrib>Pfahler, Wolfram</creatorcontrib><creatorcontrib>Tricoche, Nancy</creatorcontrib><creatorcontrib>Andrus, Linda</creatorcontrib><creatorcontrib>Shata, Mohamed T.</creatorcontrib><title>Protection against Chronic Hepatitis C Virus Infection after Rechallenge with Homologous, but Not Heterologous, Genotypes in a Chimpanzee Model</title><title>The Journal of infectious diseases</title><addtitle>The Journal of Infectious Diseases</addtitle><addtitle>The Journal of Infectious Diseases</addtitle><description>An open question for hepatitis C virus (HCV) vaccine development is whether the various genotypes of this virus protect against the development of chronic infection after heterologous infection with different genotypes. We approached this question by challenging chimpanzees that had recovered from HCV genotype 1a or 1b infection with 6 heterologous genotypes as well as with a homologous genotype (for chimpanzees originally infected with genotype 1a). All 9 chimpanzees rechallenged with a homologous genotype developed self-limited infections. Of 11 chimpanzees challenged with 100 chimpanzee infectious doses of heterologous genotypes, 6 developed self-limited infections, with peak viral loads in acute-phase serum that were ∼5-fold lower than those seen during primary infections. One chimpanzee (which had recovered from genotype 1b infection and was rechallenged with genotype 6a) did not develop viremia but did show an anamnestic cell-mediated immune response after rechallenge. Four of the 11 chimpanzees rechallenged with heterologous genotypes developed chronic infections with the genotypes used for rechallenge. These findings suggest that a universally protective HCV vaccine may need to incorporate epitopes from multiple genotypes</description><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Disease Models, Animal</subject><subject>Enzyme linked immunospot assay</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Genotype</subject><subject>Genotypes</subject><subject>Hepacivirus</subject><subject>Hepacivirus - classification</subject><subject>Hepacivirus - genetics</subject><subject>Hepacivirus - immunology</subject><subject>Hepacivirus - pathogenicity</subject><subject>Hepatitis C virus</subject><subject>Hepatitis C, Chronic - immunology</subject><subject>Hepatitis C, Chronic - prevention & control</subject><subject>Hepatitis C, Chronic - virology</subject><subject>Human viral diseases</subject><subject>Humans</subject><subject>Immunity</subject><subject>Infections</subject><subject>Infectious diseases</subject><subject>Interferon-gamma - biosynthesis</subject><subject>Medical sciences</subject><subject>Microbiology</subject><subject>Pan troglodytes - immunology</subject><subject>Pan troglodytes - virology</subject><subject>RNA</subject><subject>RNA, Viral - blood</subject><subject>RNA, Viral - immunology</subject><subject>T lymphocytes</subject><subject>Viral diseases</subject><subject>Viral hepatitis</subject><subject>Viral load</subject><subject>Viremia</subject><subject>Viremia - prevention & control</subject><subject>Viremia - virology</subject><subject>Viruses</subject><issn>0022-1899</issn><issn>1537-6613</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkt2KEzEYhoMobrfqHShxQY8czc_MJDmUqtuFri6iIp6ENPNNmzqdjEkGXW_CWzZLawuCeBSS9-F9v58g9ICS55TI-kWpainVLTShFRdFXVN-G00IYaygUqkTdBrjhhBS8lrcRSe0ZryitZigX1fBJ7DJ-R6blXF9THi2Dr53Fs9hMMklF_EMf3JhjPiib_-wbYKA34Ndm66DfgX4u0trPPdb3_mVH-MzvBwTfutTtsno4fUcep-uB4jYZZec5baD6X8C4EvfQHcP3WlNF-H-_pyij29ef5jNi8W784vZy0VhS8lT0ZrSCF6VhlADVomWU6gs46Bkk1sk1thKECWtaExbgmwkq6xplqZc5rsEPkVPd75D8N9GiElvXbTQdaaHXKeuZa2kEOV_QSpKxlSe-hSd_QVu_Bj63IRmjCvCmeJHNxt8jAFaPQS3NeFaU6JvFql3i8zgo73buNxCc8T2m8vAkz1gojVdG0xvXTxygufE8ibx8Y7z4_DvsIc7ZhOTDweKESrzn6FZL3a6iwl-HHQTvupciaj0_PMXPavE4urVJdOE_wakDMj2</recordid><startdate>20051115</startdate><enddate>20051115</enddate><creator>Prince, Alfred M.</creator><creator>Brotman, Betsy</creator><creator>Lee, Dong-Hun</creator><creator>Pfahler, Wolfram</creator><creator>Tricoche, Nancy</creator><creator>Andrus, Linda</creator><creator>Shata, Mohamed T.</creator><general>The University of Chicago Press</general><general>University of Chicago Press</general><general>Oxford University Press</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>7T5</scope><scope>7U9</scope><scope>H94</scope><scope>7X8</scope></search><sort><creationdate>20051115</creationdate><title>Protection against Chronic Hepatitis C Virus Infection after Rechallenge with Homologous, but Not Heterologous, Genotypes in a Chimpanzee Model</title><author>Prince, Alfred M. ; Brotman, Betsy ; Lee, Dong-Hun ; Pfahler, Wolfram ; Tricoche, Nancy ; Andrus, Linda ; Shata, Mohamed T.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c483t-fa4a7354a01aec97f31e5c23e98d3670cac57098c7daf4e8d825cadba4baf48e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Disease Models, Animal</topic><topic>Enzyme linked immunospot assay</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Genotype</topic><topic>Genotypes</topic><topic>Hepacivirus</topic><topic>Hepacivirus - classification</topic><topic>Hepacivirus - genetics</topic><topic>Hepacivirus - immunology</topic><topic>Hepacivirus - pathogenicity</topic><topic>Hepatitis C virus</topic><topic>Hepatitis C, Chronic - immunology</topic><topic>Hepatitis C, Chronic - prevention & control</topic><topic>Hepatitis C, Chronic - virology</topic><topic>Human viral diseases</topic><topic>Humans</topic><topic>Immunity</topic><topic>Infections</topic><topic>Infectious diseases</topic><topic>Interferon-gamma - biosynthesis</topic><topic>Medical sciences</topic><topic>Microbiology</topic><topic>Pan troglodytes - immunology</topic><topic>Pan troglodytes - virology</topic><topic>RNA</topic><topic>RNA, Viral - blood</topic><topic>RNA, Viral - immunology</topic><topic>T lymphocytes</topic><topic>Viral diseases</topic><topic>Viral hepatitis</topic><topic>Viral load</topic><topic>Viremia</topic><topic>Viremia - prevention & control</topic><topic>Viremia - virology</topic><topic>Viruses</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Prince, Alfred M.</creatorcontrib><creatorcontrib>Brotman, Betsy</creatorcontrib><creatorcontrib>Lee, Dong-Hun</creatorcontrib><creatorcontrib>Pfahler, Wolfram</creatorcontrib><creatorcontrib>Tricoche, Nancy</creatorcontrib><creatorcontrib>Andrus, Linda</creatorcontrib><creatorcontrib>Shata, Mohamed T.</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>Immunology Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>The Journal of infectious diseases</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Prince, Alfred M.</au><au>Brotman, Betsy</au><au>Lee, Dong-Hun</au><au>Pfahler, Wolfram</au><au>Tricoche, Nancy</au><au>Andrus, Linda</au><au>Shata, Mohamed T.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Protection against Chronic Hepatitis C Virus Infection after Rechallenge with Homologous, but Not Heterologous, Genotypes in a Chimpanzee Model</atitle><jtitle>The Journal of infectious diseases</jtitle><stitle>The Journal of Infectious Diseases</stitle><addtitle>The Journal of Infectious Diseases</addtitle><date>2005-11-15</date><risdate>2005</risdate><volume>192</volume><issue>10</issue><spage>1701</spage><epage>1709</epage><pages>1701-1709</pages><issn>0022-1899</issn><eissn>1537-6613</eissn><coden>JIDIAQ</coden><abstract>An open question for hepatitis C virus (HCV) vaccine development is whether the various genotypes of this virus protect against the development of chronic infection after heterologous infection with different genotypes. We approached this question by challenging chimpanzees that had recovered from HCV genotype 1a or 1b infection with 6 heterologous genotypes as well as with a homologous genotype (for chimpanzees originally infected with genotype 1a). All 9 chimpanzees rechallenged with a homologous genotype developed self-limited infections. Of 11 chimpanzees challenged with 100 chimpanzee infectious doses of heterologous genotypes, 6 developed self-limited infections, with peak viral loads in acute-phase serum that were ∼5-fold lower than those seen during primary infections. One chimpanzee (which had recovered from genotype 1b infection and was rechallenged with genotype 6a) did not develop viremia but did show an anamnestic cell-mediated immune response after rechallenge. Four of the 11 chimpanzees rechallenged with heterologous genotypes developed chronic infections with the genotypes used for rechallenge. These findings suggest that a universally protective HCV vaccine may need to incorporate epitopes from multiple genotypes</abstract><cop>Chicago, IL</cop><pub>The University of Chicago Press</pub><pmid>16235167</pmid><doi>10.1086/496889</doi><tpages>9</tpages><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; JSTOR Archive Collection A-Z Listing; Oxford University Press Journals All Titles (1996-Current); Alma/SFX Local Collection |
| subjects | Animals Biological and medical sciences Disease Models, Animal Enzyme linked immunospot assay Fundamental and applied biological sciences. Psychology Genotype Genotypes Hepacivirus Hepacivirus - classification Hepacivirus - genetics Hepacivirus - immunology Hepacivirus - pathogenicity Hepatitis C virus Hepatitis C, Chronic - immunology Hepatitis C, Chronic - prevention & control Hepatitis C, Chronic - virology Human viral diseases Humans Immunity Infections Infectious diseases Interferon-gamma - biosynthesis Medical sciences Microbiology Pan troglodytes - immunology Pan troglodytes - virology RNA RNA, Viral - blood RNA, Viral - immunology T lymphocytes Viral diseases Viral hepatitis Viral load Viremia Viremia - prevention & control Viremia - virology Viruses |
| title | Protection against Chronic Hepatitis C Virus Infection after Rechallenge with Homologous, but Not Heterologous, Genotypes in a Chimpanzee Model |
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