$A Dose-Ranging Study of the Efficacy and Tolerability of Entecavir in Lamivudine-Refractory Chronic Hepatitis B Patients$

A Dose-Ranging Study of the Efficacy and Tolerability of Entecavir in Lamivudine-Refractory Chronic Hepatitis B Patients

Background & Aims: Entecavir is a nucleoside analogue with potent in vitro activity against lamivudine-resistant hepatitis B virus (HBV). This randomized, dose-ranging, phase 2 study compared the efficacy and safety of entecavir with lamivudine in lamivudine-refractory patients. Methods: Hepatit...

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Veröffentlicht in:	Gastroenterology (New York, N.Y. 1943) N.Y. 1943), 2005-10, Vol.129 (4), p.1198-1209
Hauptverfasser:	Chang, Ting–Tsung, Gish, Robert G., Hadziyannis, Stephanos J., Cianciara, Janusz, Rizzetto, Mario, Schiff, Eugene R., Pastore, Giuseppe, Bacon, Bruce R., Poynard, Thierry, Joshi, Shobha, Klesczewski, Kenneth S., Thiry, Alexandra, Rose, Ronald E., Colonno, Richard J., Hindes, Robert G.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Antigens, Viral - blood Antiviral Agents - therapeutic use DNA, Viral - genetics DNA, Viral - isolation & purification Dose-Response Relationship, Drug Double-Blind Method Ethnic Groups Female Guanine - analogs & derivatives Guanine - therapeutic use Hepatitis B e Antigens - blood Hepatitis B virus - genetics Hepatitis B virus - isolation & purification Hepatitis B, Chronic - drug therapy Humans Lamivudine - therapeutic use Male Middle Aged
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