Genetic inflammatory factors predict restenosis after percutaneous coronary interventions
Restenosis is a negative effect of percutaneous coronary intervention (PCI). No clinical factors are available that allow good risk stratification. However, evidence exists that genetic factors are important in the restenotic process as well as in the process of inflammation, a pivotal factor in res...
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| creator | MONRAATS, Pascalle S PIRES, Nuno M. M FRANTS, Rune R QUAX, Paul H. A VAN VLIJMEN, Bart J. M ATSMA, Douwe E VAN DER LAARSE, Arnoud VAN DER WALL, Ernst E JUKEMA, J. Wouter AGEMA, Willem R. P ZWINDERMAN, Aeiiko H SCHEPERS, Abbey DE MAAT, Moniek P. M DOEVENDANS, Pieter A DE WINTER, Robbert J TIO, René A WALTENBERGER, Johannes |
| description | Restenosis is a negative effect of percutaneous coronary intervention (PCI). No clinical factors are available that allow good risk stratification. However, evidence exists that genetic factors are important in the restenotic process as well as in the process of inflammation, a pivotal factor in restenosis. Association studies have identified genes that may predispose to restenosis, but confirmation by large prospective studies is lacking. Our aim was to identify polymorphisms and haplotypes in genes involved in inflammatory pathways that predispose to restenosis.
The GENetic DEterminants of Restenosis (GENDER) project is a multicenter prospective study, including 3104 consecutive patients after successful PCI. Forty-eight polymorphisms in 34 genes in pathways possibly involved in the inflammatory process were analyzed. The 16Gly variant of the beta2-adrenergic receptor gave an increased risk of target vessel revascularization (TVR). The rare alleles of the CD14 gene (-260T/T), colony-stimulating factor 2 gene (117Thr/Thr), and eotaxin gene (-1328A/A) were associated with decreased risk of TVR. However, through the use of multiple testing corrections with permutation analysis, the probability of finding 4 significant markers by chance was 12%.
Polymorphisms in 4 genes considered involved in the inflammatory reaction showed an association with TVR after PCI. Our results may contribute to the unraveling of the restenotic process. Given the explorative nature of this analysis, our results need to be replicated in other studies. |
| doi_str_mv | 10.1161/CIRCULATIONAHA.105.536268 |
| format | Article |
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The GENetic DEterminants of Restenosis (GENDER) project is a multicenter prospective study, including 3104 consecutive patients after successful PCI. Forty-eight polymorphisms in 34 genes in pathways possibly involved in the inflammatory process were analyzed. The 16Gly variant of the beta2-adrenergic receptor gave an increased risk of target vessel revascularization (TVR). The rare alleles of the CD14 gene (-260T/T), colony-stimulating factor 2 gene (117Thr/Thr), and eotaxin gene (-1328A/A) were associated with decreased risk of TVR. However, through the use of multiple testing corrections with permutation analysis, the probability of finding 4 significant markers by chance was 12%.
Polymorphisms in 4 genes considered involved in the inflammatory reaction showed an association with TVR after PCI. Our results may contribute to the unraveling of the restenotic process. Given the explorative nature of this analysis, our results need to be replicated in other studies.</description><identifier>ISSN: 0009-7322</identifier><identifier>EISSN: 1524-4539</identifier><identifier>DOI: 10.1161/CIRCULATIONAHA.105.536268</identifier><identifier>PMID: 16230497</identifier><identifier>CODEN: CIRCAZ</identifier><language>eng</language><publisher>Hagerstown, MD: Lippincott Williams & Wilkins</publisher><subject>Amino Acid Substitution ; Angioplasty, Balloon, Coronary ; Biological and medical sciences ; Blood and lymphatic vessels ; Cardiology. Vascular system ; Coronary heart disease ; Coronary Restenosis - genetics ; Diseases of the peripheral vessels. Diseases of the vena cava. Miscellaneous ; Heart ; Humans ; Inflammation - genetics ; Medical sciences ; Neurology ; Polymorphism, Single Nucleotide ; Prospective Studies ; Treatment Outcome ; Vascular diseases and vascular malformations of the nervous system</subject><ispartof>Circulation (New York, N.Y.), 2005-10, Vol.112 (16), p.2417-2425</ispartof><rights>2006 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c470t-a09559c4270d99645d44a9d62563933c1d3758e64e464dbc2db33c3844db89153</citedby><cites>FETCH-LOGICAL-c470t-a09559c4270d99645d44a9d62563933c1d3758e64e464dbc2db33c3844db89153</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,3674,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=17269553$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16230497$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>MONRAATS, Pascalle S</creatorcontrib><creatorcontrib>PIRES, Nuno M. M</creatorcontrib><creatorcontrib>FRANTS, Rune R</creatorcontrib><creatorcontrib>QUAX, Paul H. A</creatorcontrib><creatorcontrib>VAN VLIJMEN, Bart J. M</creatorcontrib><creatorcontrib>ATSMA, Douwe E</creatorcontrib><creatorcontrib>VAN DER LAARSE, Arnoud</creatorcontrib><creatorcontrib>VAN DER WALL, Ernst E</creatorcontrib><creatorcontrib>JUKEMA, J. Wouter</creatorcontrib><creatorcontrib>AGEMA, Willem R. P</creatorcontrib><creatorcontrib>ZWINDERMAN, Aeiiko H</creatorcontrib><creatorcontrib>SCHEPERS, Abbey</creatorcontrib><creatorcontrib>DE MAAT, Moniek P. M</creatorcontrib><creatorcontrib>DOEVENDANS, Pieter A</creatorcontrib><creatorcontrib>DE WINTER, Robbert J</creatorcontrib><creatorcontrib>TIO, René A</creatorcontrib><creatorcontrib>WALTENBERGER, Johannes</creatorcontrib><title>Genetic inflammatory factors predict restenosis after percutaneous coronary interventions</title><title>Circulation (New York, N.Y.)</title><addtitle>Circulation</addtitle><description>Restenosis is a negative effect of percutaneous coronary intervention (PCI). No clinical factors are available that allow good risk stratification. However, evidence exists that genetic factors are important in the restenotic process as well as in the process of inflammation, a pivotal factor in restenosis. Association studies have identified genes that may predispose to restenosis, but confirmation by large prospective studies is lacking. Our aim was to identify polymorphisms and haplotypes in genes involved in inflammatory pathways that predispose to restenosis.
The GENetic DEterminants of Restenosis (GENDER) project is a multicenter prospective study, including 3104 consecutive patients after successful PCI. Forty-eight polymorphisms in 34 genes in pathways possibly involved in the inflammatory process were analyzed. The 16Gly variant of the beta2-adrenergic receptor gave an increased risk of target vessel revascularization (TVR). The rare alleles of the CD14 gene (-260T/T), colony-stimulating factor 2 gene (117Thr/Thr), and eotaxin gene (-1328A/A) were associated with decreased risk of TVR. However, through the use of multiple testing corrections with permutation analysis, the probability of finding 4 significant markers by chance was 12%.
Polymorphisms in 4 genes considered involved in the inflammatory reaction showed an association with TVR after PCI. Our results may contribute to the unraveling of the restenotic process. Given the explorative nature of this analysis, our results need to be replicated in other studies.</description><subject>Amino Acid Substitution</subject><subject>Angioplasty, Balloon, Coronary</subject><subject>Biological and medical sciences</subject><subject>Blood and lymphatic vessels</subject><subject>Cardiology. Vascular system</subject><subject>Coronary heart disease</subject><subject>Coronary Restenosis - genetics</subject><subject>Diseases of the peripheral vessels. Diseases of the vena cava. Miscellaneous</subject><subject>Heart</subject><subject>Humans</subject><subject>Inflammation - genetics</subject><subject>Medical sciences</subject><subject>Neurology</subject><subject>Polymorphism, Single Nucleotide</subject><subject>Prospective Studies</subject><subject>Treatment Outcome</subject><subject>Vascular diseases and vascular malformations of the nervous system</subject><issn>0009-7322</issn><issn>1524-4539</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFUU1Lw0AQXUSxtfoXJB70lrrfyR5D0bZQLEh78BS2mw2sJJu4uxH8964kIJ48DTPz3sybeQDcIbhEiKPH1fZ1ddwVh-3-pdgUSwTZkhGOeX4G5ohhmlJGxDmYQwhFmhGMZ-DK-_eYcpKxSzBDHBNIRTYHb2ttdTAqMbZuZNvK0LmvpJYqRp_0TldGhcRpH7TtvPGJrIN2Sa-dGoK0uht8ojrXWRlpxsbep7bBdNZfg4taNl7fTHEBjs9Ph9Um3e3X21WxSxXNYEglFIwJRXEGKyE4ZRWlUlQcM04EIQpVUXKuOdWU0-qkcHWKVZLTmOQCMbIAD-Pc3nUfQxRatsYr3TSjupLnXGQZpv8CMcKE5nHnAogRqFznvdN12TvTxgNLBMsfA8q_BsQyK0cDIvd2WjKcWl39MqePR8D9BJBeyaZ20irjf3EZ5vEhhHwDcC2RMg</recordid><startdate>20051018</startdate><enddate>20051018</enddate><creator>MONRAATS, Pascalle S</creator><creator>PIRES, Nuno M. 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Miscellaneous</topic><topic>Heart</topic><topic>Humans</topic><topic>Inflammation - genetics</topic><topic>Medical sciences</topic><topic>Neurology</topic><topic>Polymorphism, Single Nucleotide</topic><topic>Prospective Studies</topic><topic>Treatment Outcome</topic><topic>Vascular diseases and vascular malformations of the nervous system</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>MONRAATS, Pascalle S</creatorcontrib><creatorcontrib>PIRES, Nuno M. M</creatorcontrib><creatorcontrib>FRANTS, Rune R</creatorcontrib><creatorcontrib>QUAX, Paul H. A</creatorcontrib><creatorcontrib>VAN VLIJMEN, Bart J. M</creatorcontrib><creatorcontrib>ATSMA, Douwe E</creatorcontrib><creatorcontrib>VAN DER LAARSE, Arnoud</creatorcontrib><creatorcontrib>VAN DER WALL, Ernst E</creatorcontrib><creatorcontrib>JUKEMA, J. Wouter</creatorcontrib><creatorcontrib>AGEMA, Willem R. P</creatorcontrib><creatorcontrib>ZWINDERMAN, Aeiiko H</creatorcontrib><creatorcontrib>SCHEPERS, Abbey</creatorcontrib><creatorcontrib>DE MAAT, Moniek P. M</creatorcontrib><creatorcontrib>DOEVENDANS, Pieter A</creatorcontrib><creatorcontrib>DE WINTER, Robbert J</creatorcontrib><creatorcontrib>TIO, René A</creatorcontrib><creatorcontrib>WALTENBERGER, Johannes</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Circulation (New York, N.Y.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>MONRAATS, Pascalle S</au><au>PIRES, Nuno M. M</au><au>FRANTS, Rune R</au><au>QUAX, Paul H. A</au><au>VAN VLIJMEN, Bart J. M</au><au>ATSMA, Douwe E</au><au>VAN DER LAARSE, Arnoud</au><au>VAN DER WALL, Ernst E</au><au>JUKEMA, J. Wouter</au><au>AGEMA, Willem R. P</au><au>ZWINDERMAN, Aeiiko H</au><au>SCHEPERS, Abbey</au><au>DE MAAT, Moniek P. M</au><au>DOEVENDANS, Pieter A</au><au>DE WINTER, Robbert J</au><au>TIO, René A</au><au>WALTENBERGER, Johannes</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Genetic inflammatory factors predict restenosis after percutaneous coronary interventions</atitle><jtitle>Circulation (New York, N.Y.)</jtitle><addtitle>Circulation</addtitle><date>2005-10-18</date><risdate>2005</risdate><volume>112</volume><issue>16</issue><spage>2417</spage><epage>2425</epage><pages>2417-2425</pages><issn>0009-7322</issn><eissn>1524-4539</eissn><coden>CIRCAZ</coden><abstract>Restenosis is a negative effect of percutaneous coronary intervention (PCI). No clinical factors are available that allow good risk stratification. However, evidence exists that genetic factors are important in the restenotic process as well as in the process of inflammation, a pivotal factor in restenosis. Association studies have identified genes that may predispose to restenosis, but confirmation by large prospective studies is lacking. Our aim was to identify polymorphisms and haplotypes in genes involved in inflammatory pathways that predispose to restenosis.
The GENetic DEterminants of Restenosis (GENDER) project is a multicenter prospective study, including 3104 consecutive patients after successful PCI. Forty-eight polymorphisms in 34 genes in pathways possibly involved in the inflammatory process were analyzed. The 16Gly variant of the beta2-adrenergic receptor gave an increased risk of target vessel revascularization (TVR). The rare alleles of the CD14 gene (-260T/T), colony-stimulating factor 2 gene (117Thr/Thr), and eotaxin gene (-1328A/A) were associated with decreased risk of TVR. However, through the use of multiple testing corrections with permutation analysis, the probability of finding 4 significant markers by chance was 12%.
Polymorphisms in 4 genes considered involved in the inflammatory reaction showed an association with TVR after PCI. Our results may contribute to the unraveling of the restenotic process. Given the explorative nature of this analysis, our results need to be replicated in other studies.</abstract><cop>Hagerstown, MD</cop><pub>Lippincott Williams & Wilkins</pub><pmid>16230497</pmid><doi>10.1161/CIRCULATIONAHA.105.536268</doi><tpages>9</tpages><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; American Heart Association Journals; EZB-FREE-00999 freely available EZB journals; Journals@Ovid Complete |
| subjects | Amino Acid Substitution Angioplasty, Balloon, Coronary Biological and medical sciences Blood and lymphatic vessels Cardiology. Vascular system Coronary heart disease Coronary Restenosis - genetics Diseases of the peripheral vessels. Diseases of the vena cava. Miscellaneous Heart Humans Inflammation - genetics Medical sciences Neurology Polymorphism, Single Nucleotide Prospective Studies Treatment Outcome Vascular diseases and vascular malformations of the nervous system |
| title | Genetic inflammatory factors predict restenosis after percutaneous coronary interventions |
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