Development of a Multiplexed Interface for Capillary Electrophoresis−Electrospray Ion Trap Mass Spectrometry
A four-channel multiplexed electrospray capillary electrophoresis interface has been developed. This new interface permits up to four capillary electrophoresis columns to be sampled sequentially by means of a stepper motor and a notched rotating plate assembly, which at any instant occludes all but...
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| Veröffentlicht in: | Analytical chemistry (Washington) 2006-08, Vol.78 (15), p.5316-5321 |
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| creator | Li, Fu-An Wu, Ming-Chi Her, Guor-Rong |
| description | A four-channel multiplexed electrospray capillary electrophoresis interface has been developed. This new interface permits up to four capillary electrophoresis columns to be sampled sequentially by means of a stepper motor and a notched rotating plate assembly, which at any instant occludes all but a single sprayer. In this design, four sheath liquid electrospray probes are oriented in a circular array situated 90° relative to one another. The rotating metal disk, which contains a one-quarter notch, is mounted to the stepper motor assembly and is located between the sprayers and the entrance aperture of an ion trap mass spectrometer. By using the data acquisition signal from the ion trap mass spectrometer, the scan event is synchronized with the rotation of the metal disk. With this device, four discrete sample streams can be simultaneously analyzed, resulting in a 4-fold increase in analytical throughput. |
| doi_str_mv | 10.1021/ac052272w |
| format | Article |
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This new interface permits up to four capillary electrophoresis columns to be sampled sequentially by means of a stepper motor and a notched rotating plate assembly, which at any instant occludes all but a single sprayer. In this design, four sheath liquid electrospray probes are oriented in a circular array situated 90° relative to one another. The rotating metal disk, which contains a one-quarter notch, is mounted to the stepper motor assembly and is located between the sprayers and the entrance aperture of an ion trap mass spectrometer. By using the data acquisition signal from the ion trap mass spectrometer, the scan event is synchronized with the rotation of the metal disk. 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Chem</addtitle><description>A four-channel multiplexed electrospray capillary electrophoresis interface has been developed. This new interface permits up to four capillary electrophoresis columns to be sampled sequentially by means of a stepper motor and a notched rotating plate assembly, which at any instant occludes all but a single sprayer. In this design, four sheath liquid electrospray probes are oriented in a circular array situated 90° relative to one another. The rotating metal disk, which contains a one-quarter notch, is mounted to the stepper motor assembly and is located between the sprayers and the entrance aperture of an ion trap mass spectrometer. By using the data acquisition signal from the ion trap mass spectrometer, the scan event is synchronized with the rotation of the metal disk. 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Wu, Ming-Chi ; Her, Guor-Rong</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-a408t-488aab6545d85babacb86cf315c2fbab60f6df0b509f3f0bdfc2731c6c785c513</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2006</creationdate><topic>Analytical chemistry</topic><topic>Chemistry</topic><topic>Chromatographic methods and physical methods associated with chromatography</topic><topic>Electrophoresis, Capillary - instrumentation</topic><topic>Electrophoresis, Capillary - methods</topic><topic>Equipment Design</topic><topic>Exact sciences and technology</topic><topic>Mass spectrometry</topic><topic>Multiplexers</topic><topic>Other chromatographic methods</topic><topic>Reproducibility of Results</topic><topic>Scientific apparatus & instruments</topic><topic>Sensitivity and Specificity</topic><topic>Spectrometric and optical methods</topic><topic>Spectrometry, Mass, Electrospray Ionization - instrumentation</topic><topic>Spectrometry, Mass, Electrospray Ionization - methods</topic><topic>Surface Properties</topic><topic>Time Factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Li, Fu-An</creatorcontrib><creatorcontrib>Wu, Ming-Chi</creatorcontrib><creatorcontrib>Her, Guor-Rong</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Aluminium Industry Abstracts</collection><collection>Biotechnology Research Abstracts</collection><collection>Ceramic Abstracts</collection><collection>Computer and Information Systems Abstracts</collection><collection>Corrosion Abstracts</collection><collection>Electronics & Communications Abstracts</collection><collection>Engineered Materials Abstracts</collection><collection>Materials Business File</collection><collection>Mechanical & Transportation Engineering Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Solid State and Superconductivity Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>METADEX</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ANTE: Abstracts in New Technology & Engineering</collection><collection>Engineering Research Database</collection><collection>Aerospace Database</collection><collection>Copper Technical Reference Library</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Materials Research Database</collection><collection>ProQuest Computer Science Collection</collection><collection>Civil Engineering Abstracts</collection><collection>Advanced Technologies Database with Aerospace</collection><collection>Computer and Information Systems Abstracts Academic</collection><collection>Computer and Information Systems Abstracts Professional</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Analytical chemistry (Washington)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Li, Fu-An</au><au>Wu, Ming-Chi</au><au>Her, Guor-Rong</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Development of a Multiplexed Interface for Capillary Electrophoresis−Electrospray Ion Trap Mass Spectrometry</atitle><jtitle>Analytical chemistry (Washington)</jtitle><addtitle>Anal. Chem</addtitle><date>2006-08-01</date><risdate>2006</risdate><volume>78</volume><issue>15</issue><spage>5316</spage><epage>5321</epage><pages>5316-5321</pages><issn>0003-2700</issn><eissn>1520-6882</eissn><coden>ANCHAM</coden><abstract>A four-channel multiplexed electrospray capillary electrophoresis interface has been developed. This new interface permits up to four capillary electrophoresis columns to be sampled sequentially by means of a stepper motor and a notched rotating plate assembly, which at any instant occludes all but a single sprayer. In this design, four sheath liquid electrospray probes are oriented in a circular array situated 90° relative to one another. The rotating metal disk, which contains a one-quarter notch, is mounted to the stepper motor assembly and is located between the sprayers and the entrance aperture of an ion trap mass spectrometer. 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| subjects | Analytical chemistry Chemistry Chromatographic methods and physical methods associated with chromatography Electrophoresis, Capillary - instrumentation Electrophoresis, Capillary - methods Equipment Design Exact sciences and technology Mass spectrometry Multiplexers Other chromatographic methods Reproducibility of Results Scientific apparatus & instruments Sensitivity and Specificity Spectrometric and optical methods Spectrometry, Mass, Electrospray Ionization - instrumentation Spectrometry, Mass, Electrospray Ionization - methods Surface Properties Time Factors |
| title | Development of a Multiplexed Interface for Capillary Electrophoresis−Electrospray Ion Trap Mass Spectrometry |
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