Control of murine gammaherpesvirus infection is independent of NK cells
Numerous studies have shown that NK cells are important in controlling the early stages of infection with alpha‐ or betaherpesviruses. In contrast, little is known about the impact of NK cells on gammaherpesvirus infections. We tested mice with defects in NK cells for their ability to resist murine...
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| Veröffentlicht in: | European Journal of Immunology 2005-10, Vol.35 (10), p.2956-2961 |
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| container_title | European Journal of Immunology |
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| creator | Usherwood, Edward J. Meadows, Sarah K. Crist, Sarah G. Bellfy, Sarah C. Sentman, Charles L. |
| description | Numerous studies have shown that NK cells are important in controlling the early stages of infection with alpha‐ or betaherpesviruses. In contrast, little is known about the impact of NK cells on gammaherpesvirus infections. We tested mice with defects in NK cells for their ability to resist murine gammaherpesvirus (MHV‐68) infection. The depletion of NK cells had no effect on the control of the acute or latent stages of the infection. In addition, transgenic mice deficient in NK cells controlled the infection in a comparable manner to wild‐type mice. We also showed that the antiviral CD8 T cell response was unaffected by the presence or absence NK cells. We conclude that NK cells contribute little to the control of MHV‐68 infection, and therefore, NK cells are not essential for controlling all herpesvirus infections. |
| doi_str_mv | 10.1002/eji.200526245 |
| format | Article |
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In contrast, little is known about the impact of NK cells on gammaherpesvirus infections. We tested mice with defects in NK cells for their ability to resist murine gammaherpesvirus (MHV‐68) infection. The depletion of NK cells had no effect on the control of the acute or latent stages of the infection. In addition, transgenic mice deficient in NK cells controlled the infection in a comparable manner to wild‐type mice. We also showed that the antiviral CD8 T cell response was unaffected by the presence or absence NK cells. We conclude that NK cells contribute little to the control of MHV‐68 infection, and therefore, NK cells are not essential for controlling all herpesvirus infections.</description><identifier>ISSN: 0014-2980</identifier><identifier>EISSN: 1521-4141</identifier><identifier>EISSN: 1365-2567</identifier><identifier>DOI: 10.1002/eji.200526245</identifier><identifier>PMID: 16134085</identifier><language>eng</language><publisher>Weinheim: WILEY‐VCH Verlag</publisher><subject>Animals ; Epstein‐Barr virus ; Flow Cytometry ; Gammaherpesvirinae - immunology ; Herpesviridae Infections - immunology ; Killer Cells, Natural - immunology ; Killer Cells, Natural - virology ; Mice ; Mice, Transgenic ; Murine gammaherpesvirus ; Murine gamma‐herpesvirus ; NK cells ; Polymerase Chain Reaction ; Respiratory virus ; Virus</subject><ispartof>European Journal of Immunology, 2005-10, Vol.35 (10), p.2956-2961</ispartof><rights>Copyright © 2005 WILEY‐VCH Verlag GmbH & Co. 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In contrast, little is known about the impact of NK cells on gammaherpesvirus infections. We tested mice with defects in NK cells for their ability to resist murine gammaherpesvirus (MHV‐68) infection. The depletion of NK cells had no effect on the control of the acute or latent stages of the infection. In addition, transgenic mice deficient in NK cells controlled the infection in a comparable manner to wild‐type mice. We also showed that the antiviral CD8 T cell response was unaffected by the presence or absence NK cells. We conclude that NK cells contribute little to the control of MHV‐68 infection, and therefore, NK cells are not essential for controlling all herpesvirus infections.</description><subject>Animals</subject><subject>Epstein‐Barr virus</subject><subject>Flow Cytometry</subject><subject>Gammaherpesvirinae - immunology</subject><subject>Herpesviridae Infections - immunology</subject><subject>Killer Cells, Natural - immunology</subject><subject>Killer Cells, Natural - virology</subject><subject>Mice</subject><subject>Mice, Transgenic</subject><subject>Murine gammaherpesvirus</subject><subject>Murine gamma‐herpesvirus</subject><subject>NK cells</subject><subject>Polymerase Chain Reaction</subject><subject>Respiratory virus</subject><subject>Virus</subject><issn>0014-2980</issn><issn>1521-4141</issn><issn>1365-2567</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkD1PwzAQhi0EoqUwsqJMbCk-x06cEVVQChUsMFtOcgZX-cJOQP33JGpFN1judNJzr-4eQi6BzoFSdoMbO2eUChYzLo7IFASDkAOHYzKlFHjIUkkn5Mz7DaU0jUV6SiYQQ8SpFFOyXDR155oyaExQ9c7WGLzrqtIf6Fr0X9b1PrC1wbyzTR3YcSiwxaHU3bjz_BTkWJb-nJwYXXq82PcZebu_e108hOuX5Wpxuw5zTlMRMgSgmTZSQ5amIkIELTAyWDCphckRBWQZF1oXhmcFcOQy4dzIJAcW0Tiaketdbuuazx59pyrrxwt0jU3vVSzj4UfG_wUhiWQSR2wAwx2Yu8Z7h0a1zlbabRVQNSpWg2L1q3jgr_bBfVZhcaD3Tgcg2QHftsTt32nq7nF1iP4BoUGHfg</recordid><startdate>200510</startdate><enddate>200510</enddate><creator>Usherwood, Edward J.</creator><creator>Meadows, Sarah K.</creator><creator>Crist, Sarah G.</creator><creator>Bellfy, Sarah C.</creator><creator>Sentman, Charles L.</creator><general>WILEY‐VCH Verlag</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>7U9</scope><scope>H94</scope><scope>7X8</scope></search><sort><creationdate>200510</creationdate><title>Control of murine gammaherpesvirus infection is independent of NK cells</title><author>Usherwood, Edward J. ; Meadows, Sarah K. ; Crist, Sarah G. ; Bellfy, Sarah C. ; Sentman, Charles L.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4095-2e110baf8a1b9953ee1a5e3fed28a5fcee51bb45aadf4bd14e48744f87c123063</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>Animals</topic><topic>Epstein‐Barr virus</topic><topic>Flow Cytometry</topic><topic>Gammaherpesvirinae - immunology</topic><topic>Herpesviridae Infections - immunology</topic><topic>Killer Cells, Natural - immunology</topic><topic>Killer Cells, Natural - virology</topic><topic>Mice</topic><topic>Mice, Transgenic</topic><topic>Murine gammaherpesvirus</topic><topic>Murine gamma‐herpesvirus</topic><topic>NK cells</topic><topic>Polymerase Chain Reaction</topic><topic>Respiratory virus</topic><topic>Virus</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Usherwood, Edward J.</creatorcontrib><creatorcontrib>Meadows, Sarah K.</creatorcontrib><creatorcontrib>Crist, Sarah G.</creatorcontrib><creatorcontrib>Bellfy, Sarah C.</creatorcontrib><creatorcontrib>Sentman, Charles L.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>European Journal of Immunology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Usherwood, Edward J.</au><au>Meadows, Sarah K.</au><au>Crist, Sarah G.</au><au>Bellfy, Sarah C.</au><au>Sentman, Charles L.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Control of murine gammaherpesvirus infection is independent of NK cells</atitle><jtitle>European Journal of Immunology</jtitle><addtitle>Eur J Immunol</addtitle><date>2005-10</date><risdate>2005</risdate><volume>35</volume><issue>10</issue><spage>2956</spage><epage>2961</epage><pages>2956-2961</pages><issn>0014-2980</issn><eissn>1521-4141</eissn><eissn>1365-2567</eissn><abstract>Numerous studies have shown that NK cells are important in controlling the early stages of infection with alpha‐ or betaherpesviruses. 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| source | MEDLINE; Wiley HSS Collection; IngentaConnect Open Access Journals; Wiley Online Library (Open Access Collection); PubMed Central; EZB Electronic Journals Library |
| subjects | Animals Epstein‐Barr virus Flow Cytometry Gammaherpesvirinae - immunology Herpesviridae Infections - immunology Killer Cells, Natural - immunology Killer Cells, Natural - virology Mice Mice, Transgenic Murine gammaherpesvirus Murine gamma‐herpesvirus NK cells Polymerase Chain Reaction Respiratory virus Virus |
| title | Control of murine gammaherpesvirus infection is independent of NK cells |
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