Quality of life associated with acute and chronic graft-versus-host disease
Acute and chronic graft-versus-host diseases (GVHD) are associated with increased morbidity and mortality after hematopoietic stem cell transplantation (HCT). We prospectively measured the quality of life (QOL) of patients undergoing allogeneic transplantation. Ninety-six subjects completed self-ass...
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| Veröffentlicht in: | Bone marrow transplantation (Basingstoke) 2006-08, Vol.38 (4), p.305-310 |
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| creator | Lee, S J Kim, H T Ho, V T Cutler, C Alyea, E P Soiffer, R J Antin, J H |
| description | Acute and chronic graft-versus-host diseases (GVHD) are associated with increased morbidity and mortality after hematopoietic stem cell transplantation (HCT). We prospectively measured the quality of life (QOL) of patients undergoing allogeneic transplantation. Ninety-six subjects completed self-assessment surveys before HCT, and at 6 and/or 12 months post-HCT that included the Medical Outcomes Study Short Form 12 (SF12) and the Functional Assessment of Cancer Therapy-Bone Marrow Transplant scale. Eighty-three percent of survivors responded at 6 and 12 months. Physical and mental functioning assessed by the SF12 was not associated with either acute or chronic GVHD. In contrast, the trial outcome index (TOI) of the Functional Assessment of Cancer Therapy-Bone Marrow Transplant was sensitive to occurrence of either acute or chronic GVHD. GVHD is a major determinant of the long-term QOL of survivors. The adverse effects of acute GVHD are detectable with the TOI at 6 months post transplantation after which development of chronic GVHD is the most strongly correlated with worse QOL. |
| doi_str_mv | 10.1038/sj.bmt.1705434 |
| format | Article |
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We prospectively measured the quality of life (QOL) of patients undergoing allogeneic transplantation. Ninety-six subjects completed self-assessment surveys before HCT, and at 6 and/or 12 months post-HCT that included the Medical Outcomes Study Short Form 12 (SF12) and the Functional Assessment of Cancer Therapy-Bone Marrow Transplant scale. Eighty-three percent of survivors responded at 6 and 12 months. Physical and mental functioning assessed by the SF12 was not associated with either acute or chronic GVHD. In contrast, the trial outcome index (TOI) of the Functional Assessment of Cancer Therapy-Bone Marrow Transplant was sensitive to occurrence of either acute or chronic GVHD. GVHD is a major determinant of the long-term QOL of survivors. The adverse effects of acute GVHD are detectable with the TOI at 6 months post transplantation after which development of chronic GVHD is the most strongly correlated with worse QOL.</description><identifier>ISSN: 0268-3369</identifier><identifier>EISSN: 1476-5365</identifier><identifier>DOI: 10.1038/sj.bmt.1705434</identifier><identifier>PMID: 16819438</identifier><identifier>CODEN: BMTRE9</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>Acute Disease ; Adult ; Aged ; Analysis ; Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy ; Biological and medical sciences ; Bone cancer ; Bone marrow ; Bone marrow transplantation ; Bone marrow, stem cells transplantation. Graft versus host reaction ; Cancer ; Cancer therapies ; Causes of ; Cell Biology ; Chronic Disease ; Data Collection ; Female ; Graft versus host disease ; Graft versus host reaction ; Graft vs Host Disease ; Health aspects ; Hematology ; Hematopoietic Stem Cell Transplantation - adverse effects ; Hematopoietic stem cells ; Humans ; Internal Medicine ; Male ; Medical sciences ; Medicine ; Medicine & Public Health ; Middle Aged ; Morbidity ; original-article ; Prospective Studies ; Public Health ; Quality of Life ; Self-Assessment ; Stem cell transplantation ; Stem Cells ; Time Factors ; Transfusions. Complications. Transfusion reactions. 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We prospectively measured the quality of life (QOL) of patients undergoing allogeneic transplantation. Ninety-six subjects completed self-assessment surveys before HCT, and at 6 and/or 12 months post-HCT that included the Medical Outcomes Study Short Form 12 (SF12) and the Functional Assessment of Cancer Therapy-Bone Marrow Transplant scale. Eighty-three percent of survivors responded at 6 and 12 months. Physical and mental functioning assessed by the SF12 was not associated with either acute or chronic GVHD. In contrast, the trial outcome index (TOI) of the Functional Assessment of Cancer Therapy-Bone Marrow Transplant was sensitive to occurrence of either acute or chronic GVHD. GVHD is a major determinant of the long-term QOL of survivors. The adverse effects of acute GVHD are detectable with the TOI at 6 months post transplantation after which development of chronic GVHD is the most strongly correlated with worse QOL.</description><subject>Acute Disease</subject><subject>Adult</subject><subject>Aged</subject><subject>Analysis</subject><subject>Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy</subject><subject>Biological and medical sciences</subject><subject>Bone cancer</subject><subject>Bone marrow</subject><subject>Bone marrow transplantation</subject><subject>Bone marrow, stem cells transplantation. Graft versus host reaction</subject><subject>Cancer</subject><subject>Cancer therapies</subject><subject>Causes of</subject><subject>Cell Biology</subject><subject>Chronic Disease</subject><subject>Data Collection</subject><subject>Female</subject><subject>Graft versus host disease</subject><subject>Graft versus host reaction</subject><subject>Graft vs Host Disease</subject><subject>Health aspects</subject><subject>Hematology</subject><subject>Hematopoietic Stem Cell Transplantation - adverse effects</subject><subject>Hematopoietic stem cells</subject><subject>Humans</subject><subject>Internal Medicine</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Middle Aged</subject><subject>Morbidity</subject><subject>original-article</subject><subject>Prospective Studies</subject><subject>Public Health</subject><subject>Quality of Life</subject><subject>Self-Assessment</subject><subject>Stem cell transplantation</subject><subject>Stem Cells</subject><subject>Time Factors</subject><subject>Transfusions. 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Intensive care medicine. Transfusions. Cell therapy and gene therapy</topic><topic>Biological and medical sciences</topic><topic>Bone cancer</topic><topic>Bone marrow</topic><topic>Bone marrow transplantation</topic><topic>Bone marrow, stem cells transplantation. Graft versus host reaction</topic><topic>Cancer</topic><topic>Cancer therapies</topic><topic>Causes of</topic><topic>Cell Biology</topic><topic>Chronic Disease</topic><topic>Data Collection</topic><topic>Female</topic><topic>Graft versus host disease</topic><topic>Graft versus host reaction</topic><topic>Graft vs Host Disease</topic><topic>Health aspects</topic><topic>Hematology</topic><topic>Hematopoietic Stem Cell Transplantation - adverse effects</topic><topic>Hematopoietic stem cells</topic><topic>Humans</topic><topic>Internal Medicine</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Middle Aged</topic><topic>Morbidity</topic><topic>original-article</topic><topic>Prospective Studies</topic><topic>Public Health</topic><topic>Quality of Life</topic><topic>Self-Assessment</topic><topic>Stem cell transplantation</topic><topic>Stem Cells</topic><topic>Time Factors</topic><topic>Transfusions. Complications. 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We prospectively measured the quality of life (QOL) of patients undergoing allogeneic transplantation. Ninety-six subjects completed self-assessment surveys before HCT, and at 6 and/or 12 months post-HCT that included the Medical Outcomes Study Short Form 12 (SF12) and the Functional Assessment of Cancer Therapy-Bone Marrow Transplant scale. Eighty-three percent of survivors responded at 6 and 12 months. Physical and mental functioning assessed by the SF12 was not associated with either acute or chronic GVHD. In contrast, the trial outcome index (TOI) of the Functional Assessment of Cancer Therapy-Bone Marrow Transplant was sensitive to occurrence of either acute or chronic GVHD. GVHD is a major determinant of the long-term QOL of survivors. The adverse effects of acute GVHD are detectable with the TOI at 6 months post transplantation after which development of chronic GVHD is the most strongly correlated with worse QOL.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>16819438</pmid><doi>10.1038/sj.bmt.1705434</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Acute Disease Adult Aged Analysis Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy Biological and medical sciences Bone cancer Bone marrow Bone marrow transplantation Bone marrow, stem cells transplantation. Graft versus host reaction Cancer Cancer therapies Causes of Cell Biology Chronic Disease Data Collection Female Graft versus host disease Graft versus host reaction Graft vs Host Disease Health aspects Hematology Hematopoietic Stem Cell Transplantation - adverse effects Hematopoietic stem cells Humans Internal Medicine Male Medical sciences Medicine Medicine & Public Health Middle Aged Morbidity original-article Prospective Studies Public Health Quality of Life Self-Assessment Stem cell transplantation Stem Cells Time Factors Transfusions. Complications. Transfusion reactions. Cell and gene therapy Transplantation |
| title | Quality of life associated with acute and chronic graft-versus-host disease |
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