Phytol directly activates peroxisome proliferator-activated receptor alpha (PPARalpha) and regulates gene expression involved in lipid metabolism in PPARalpha-expressing HepG2 hepatocytes

The peroxisome proliferator-activated receptor (PPAR) is one of the indispensable transcription factors for regulating lipid metabolism in various tissues. In our screening for natural compounds that activate PPAR using luciferase assays, a branched-carbon-chain alcohol (a component of chlorophylls)...

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Veröffentlicht in:	Biochemical and biophysical research communications 2005-11, Vol.337 (2), p.440-445
Hauptverfasser:	Goto, Tsuyoshi, Takahashi, Nobuyuki, Kato, Sota, Egawa, Kahori, Ebisu, Shogo, Moriyama, Tatsuya, Fushiki, Tohru, Kawada, Teruo
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Base Sequence Clofibric Acid - pharmacology Gene Expression Regulation - drug effects Haplorhini Hepatocytes - drug effects Hepatocytes - metabolism Humans Lipid Metabolism - drug effects Liver - metabolism Luciferases - metabolism Phytanic Acid - metabolism Phytol - pharmacology PPAR alpha - drug effects PPAR alpha - metabolism Transcription Factors - genetics Tumor Cells, Cultured Up-Regulation
Online-Zugang:	Volltext
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