Hemoglobin mediated nitrite activation of soluble guanylyl cyclase

Nitrite has long been known to be vasoactive when present at large concentrations but it was thought to be inactive under physiological conditions. Surprisingly, we have recently shown that supraphysiological and near physiological concentrations of nitrite cause vasodilation in the human circulatio...

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Veröffentlicht in:	Comparative biochemistry and physiology. Part A, Molecular & integrative physiology Molecular & integrative physiology, 2005-10, Vol.142 (2), p.130-135
Hauptverfasser:	Jeffers, Anne, Xu, Xiuli, Huang, Kris T., Cho, Man, Hogg, Neil, Patel, Rakesh P., Kim-Shapiro, Daniel B.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological Assay Cell Line Computer Simulation Cyclic AMP - metabolism Cyclic GMP - metabolism Diffusion Enzyme Activation Erythrocytes - metabolism Guanylate Cyclase Hemoglobin Hemoglobins - chemistry Hemoglobins - metabolism Hemoglobins - physiology Humans Hypoxia Immunoenzyme Techniques Insecta Models, Biological Models, Chemical Nitric oxide Nitric Oxide - chemistry Nitric Oxide - metabolism Nitrite Nitrites - chemistry Receptors, Cytoplasmic and Nuclear - metabolism Red blood cell Soluble guanylate cyclase Soluble Guanylyl Cyclase Vasodilation
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