Intramembrane proteolytic cleavage by human signal peptide peptidase like 3 and malaria signal peptide peptidase

Signal peptide peptidase (SPP) is an intramembrane cleaving protease (I-CLiP) identified by its cleavage of several type II membrane signal peptides. To date, only human SPP has been directly shown to have proteolytic activity. Here we demonstrate that the most closely related human homologue of SPP...

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Veröffentlicht in:	The FASEB journal 2006-08, Vol.20 (10), p.1671-1679
Hauptverfasser:	Nyborg, Andrew C, Ladd, Thomas B, Jansen, Karen, Kukar, Thomas, Golde, Todd E
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Aspartic Acid Endopeptidases - antagonists & inhibitors Aspartic Acid Endopeptidases - genetics Aspartic Acid Endopeptidases - metabolism aspartyl protease Binding Sites Cell Death Cloning, Molecular Conserved Sequence DNA, Complementary Enzyme Inhibitors - pharmacology hepatitis C virus Humans Malaria, Falciparum - enzymology Membrane Proteins - metabolism MHC class I Plasmodium falciparum Plasmodium falciparum - enzymology Plasmodium falciparum - genetics Protozoan Proteins - metabolism Transduction, Genetic γ-secretase
Online-Zugang:	Volltext
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